6R8H

Triosephosphate isomerase from liver fluke (Fasciola hepatica).

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016853	molecular_function	isomerase activity
E	0019563	biological_process	glycerol catabolic process
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
F	0004807	molecular_function	triose-phosphate isomerase activity
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0016853	molecular_function	isomerase activity
F	0019563	biological_process	glycerol catabolic process
F	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue SO4 A 301

Chain	Residue
A	LYS14
A	HOH443
A	HOH446
A	ALA173
A	ILE174
A	GLY175
A	SER215
A	GLY236
A	GLY237
A	HOH413
A	HOH435

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site_id	AC2
Number of Residues	10
Details	binding site for residue SO4 B 301

Chain	Residue
B	LYS14
B	ALA173
B	ILE174
B	GLY175
B	SER215
B	GLY236
B	GLY237
B	HOH415
B	HOH433
B	HOH442

---

site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 C 301

Chain	Residue
C	ILE174
C	GLY175
C	SER215
C	GLY236
C	GLY237
C	HOH406
C	HOH427
C	HOH467
C	HOH473

---

site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 D 301

Chain	Residue
D	ILE174
D	GLY175
D	SER215
D	GLY236
D	GLY237
D	HOH402
D	HOH436
D	HOH439

---

site_id	AC5
Number of Residues	9
Details	binding site for residue SO4 E 301

Chain	Residue
E	GLY175
E	SER215
E	GLY236
E	GLY237
E	HOH432
E	HOH452
E	HOH457
E	HOH481
E	HOH482

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 F 301

Chain	Residue
F	ILE174
F	GLY175
F	SER215
F	GLY236
F	GLY237
F	HOH423
F	HOH436

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Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG

Chain	Residue	Details
A	ALA167-GLY177

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