6R7X
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005227 | molecular_function | calcium-activated cation channel activity |
| B | 0005229 | molecular_function | intracellularly calcium-gated chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 701 |
| Chain | Residue |
| A | ASN444 |
| A | GLN445 |
| A | GLU448 |
| A | GLU500 |
| A | GLU529 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 702 |
| Chain | Residue |
| A | GLU529 |
| A | ASP533 |
| A | TYR211 |
| A | GLU448 |
| A | ASP497 |
| A | GLU500 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 703 |
| Chain | Residue |
| A | GLU259 |
| A | ALA610 |
| A | ILE613 |
| A | ASP615 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PC1 A 704 |
| Chain | Residue |
| A | TYR315 |
| A | ASN398 |
| A | HIS399 |
| A | LEU402 |
| A | PHE409 |
| A | VAL554 |
| B | PHE611 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue UMQ A 705 |
| Chain | Residue |
| A | GLY575 |
| A | MET576 |
| A | PRO578 |
| A | ASN581 |
| A | LYS588 |
| B | UMQ901 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue UMQ A 706 |
| Chain | Residue |
| A | ARG263 |
| A | UMQ708 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue UMQ A 707 |
| Chain | Residue |
| A | LYS180 |
| A | GLU183 |
| A | PHE450 |
| A | TYR453 |
| A | ARG539 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue UMQ A 708 |
| Chain | Residue |
| A | UMQ706 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue UMQ A 709 |
| Chain | Residue |
| A | VAL422 |
| A | LYS424 |
| B | UMQ901 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue UMQ A 710 |
| Chain | Residue |
| A | PHE417 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue UMQ A 711 |
| Chain | Residue |
| A | GLU560 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue UMQ A 714 |
| Chain | Residue |
| A | SER587 |
| A | ALA589 |
| A | LEU593 |
| B | LYS424 |
| B | ILE592 |
| B | UMQ906 |
| B | UMQ910 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue UMQ B 901 |
| Chain | Residue |
| A | LYS424 |
| A | ILE592 |
| A | UMQ705 |
| A | UMQ709 |
| B | SER587 |
| B | ALA589 |
| B | LEU593 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 902 |
| Chain | Residue |
| B | ASN444 |
| B | GLN445 |
| B | GLU448 |
| B | GLU500 |
| B | GLU529 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 903 |
| Chain | Residue |
| B | TYR211 |
| B | GLU448 |
| B | ASP497 |
| B | GLU500 |
| B | GLU529 |
| B | ASP533 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 904 |
| Chain | Residue |
| B | GLU259 |
| B | ALA610 |
| B | ILE613 |
| B | ASP615 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue PC1 B 905 |
| Chain | Residue |
| A | PHE611 |
| B | TYR315 |
| B | ASN398 |
| B | HIS399 |
| B | LEU402 |
| B | PHE409 |
| B | VAL554 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue UMQ B 906 |
| Chain | Residue |
| A | UMQ714 |
| B | GLY575 |
| B | MET576 |
| B | PRO578 |
| B | ASN581 |
| B | LYS588 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue UMQ B 907 |
| Chain | Residue |
| B | ARG263 |
| B | UMQ909 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue UMQ B 908 |
| Chain | Residue |
| B | LYS180 |
| B | GLU183 |
| B | PHE450 |
| B | TYR453 |
| B | ARG539 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue UMQ B 909 |
| Chain | Residue |
| B | UMQ907 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue UMQ B 910 |
| Chain | Residue |
| A | UMQ714 |
| B | VAL422 |
| B | LYS424 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue UMQ B 911 |
| Chain | Residue |
| B | PHE417 |
| site_id | AE6 |
| Number of Residues | 1 |
| Details | binding site for residue UMQ B 912 |
| Chain | Residue |
| B | GLU560 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 236 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 222 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
