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6R6U

Crystal structure of human cis-aconitate decarboxylase

Functional Information from GO Data
ChainGOidnamespacecontents
A0002760biological_processpositive regulation of antimicrobial humoral response
A0005739cellular_componentmitochondrion
A0006952biological_processdefense response
A0006954biological_processinflammatory response
A0007566biological_processembryo implantation
A0016829molecular_functionlyase activity
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0032480biological_processnegative regulation of type I interferon production
A0034136biological_processnegative regulation of toll-like receptor 2 signaling pathway
A0034144biological_processnegative regulation of toll-like receptor 4 signaling pathway
A0035458biological_processcellular response to interferon-beta
A0042803molecular_functionprotein homodimerization activity
A0045087biological_processinnate immune response
A0045824biological_processnegative regulation of innate immune response
A0047613molecular_functionaconitate decarboxylase activity
A0050728biological_processnegative regulation of inflammatory response
A0051607biological_processdefense response to virus
A0071219biological_processcellular response to molecule of bacterial origin
A0071222biological_processcellular response to lipopolysaccharide
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071393biological_processcellular response to progesterone stimulus
A0072573biological_processtolerance induction to lipopolysaccharide
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0002760biological_processpositive regulation of antimicrobial humoral response
B0005739cellular_componentmitochondrion
B0006952biological_processdefense response
B0006954biological_processinflammatory response
B0007566biological_processembryo implantation
B0016829molecular_functionlyase activity
B0032088biological_processnegative regulation of NF-kappaB transcription factor activity
B0032480biological_processnegative regulation of type I interferon production
B0034136biological_processnegative regulation of toll-like receptor 2 signaling pathway
B0034144biological_processnegative regulation of toll-like receptor 4 signaling pathway
B0035458biological_processcellular response to interferon-beta
B0042803molecular_functionprotein homodimerization activity
B0045087biological_processinnate immune response
B0045824biological_processnegative regulation of innate immune response
B0047613molecular_functionaconitate decarboxylase activity
B0050728biological_processnegative regulation of inflammatory response
B0051607biological_processdefense response to virus
B0071219biological_processcellular response to molecule of bacterial origin
B0071222biological_processcellular response to lipopolysaccharide
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0071393biological_processcellular response to progesterone stimulus
B0072573biological_processtolerance induction to lipopolysaccharide
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue BU3 A 501
ChainResidue
AGLU150
APRO155
APHE158
APRO160
APHE245
ATYR246
AHOH743
AHOH770

site_idAC2
Number of Residues6
Detailsbinding site for residue NA A 502
ChainResidue
AGLY196
AHOH785
BALA195
BGLY196
BHOH711
AALA195

site_idAC3
Number of Residues7
Detailsbinding site for residue NA A 503
ChainResidue
ASER289
AASP400
AARG401
AHOH647
AHOH800
BHOH648
BHOH810

site_idAC4
Number of Residues4
Detailsbinding site for residue NA A 504
ChainResidue
AGLY243
ATYR246
AHOH601
AHOH847

site_idAC5
Number of Residues6
Detailsbinding site for residue BU3 B 501
ChainResidue
BPRO155
BLYS156
BGLN317
BTYR318
BHOH644
BHOH797

site_idAC6
Number of Residues6
Detailsbinding site for residue BU3 B 502
ChainResidue
BARG29
BARG32
BASP268
BTHR397
BPHE398
BHOH695

site_idAC7
Number of Residues6
Detailsbinding site for residue BU3 B 503
ChainResidue
BGLU150
BPRO155
BPHE158
BPRO160
BNA505
BHOH742

site_idAC8
Number of Residues4
Detailsbinding site for residue NA B 504
ChainResidue
AHOH849
BGLY243
BTYR246
BHOH672

site_idAC9
Number of Residues5
Detailsbinding site for residue NA B 505
ChainResidue
BLYS156
BARG157
BPHE158
BBU3503
BHOH691

site_idAD1
Number of Residues4
Detailsbinding site for residue NA B 506
ChainResidue
AHOH624
AHOH629
BGLU372
BHOH718

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PDB entries from 2024-07-24

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