6R5E

Crystal structure of the Pri1 subunit of human primase bound to 2F-ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003896	molecular_function	DNA primase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005658	cellular_component	alpha DNA polymerase:primase complex
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016779	molecular_function	nucleotidyltransferase activity
A	0032553	molecular_function	ribonucleotide binding
A	0046872	molecular_function	metal ion binding
A	1990077	cellular_component	primosome complex
E	0000287	molecular_function	magnesium ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003896	molecular_function	DNA primase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005658	cellular_component	alpha DNA polymerase:primase complex
E	0006260	biological_process	DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0008270	molecular_function	zinc ion binding
E	0016020	cellular_component	membrane
E	0016779	molecular_function	nucleotidyltransferase activity
E	0032553	molecular_function	ribonucleotide binding
E	0046872	molecular_function	metal ion binding
E	1990077	cellular_component	primosome complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS121
A	CYS122
A	CYS128
A	CYS131

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 502

Chain	Residue
A	ASP109
A	ASP111
A	MN503
A	JSQ504
A	HOH674

---

site_id	AC3
Number of Residues	7
Details	binding site for residue MN A 503

Chain	Residue
A	ASP109
A	ASP111
A	ASP306
A	MN502
A	JSQ504
A	HOH686
A	HOH756

---

site_id	AC4
Number of Residues	17
Details	binding site for residue JSQ A 504

Chain	Residue
A	ASP79
A	ASP109
A	ASP111
A	SER160
A	ARG162
A	ARG163
A	HIS166
A	HIS315
A	LEU316
A	LEU317
A	LYS318
A	HIS324
A	MN502
A	MN503
A	HOH674
A	HOH686
A	HOH750

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 505

Chain	Residue
A	THR349
A	SER351
E	ASP149
E	PHE150
E	TYR188

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 506

Chain	Residue
A	ASP335
A	PHE342
A	HOH739

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 507

Chain	Residue
A	GLU187
A	HOH627
A	HOH694
E	ARG355

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 508

Chain	Residue
A	ASP126
A	ILE127
A	HOH611

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 509

Chain	Residue
A	LYS153
A	HIS154
A	ARG155
A	ASN401
A	HOH621

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 510

Chain	Residue
A	LYS130
A	ASN230
A	HOH608
A	HOH685

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS121
E	CYS122
E	CYS128
E	CYS131

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MN E 502

Chain	Residue
E	ASP109
E	ASP111
E	MN503
E	JSQ504
E	HOH685

---

site_id	AD4
Number of Residues	7
Details	binding site for residue MN E 503

Chain	Residue
E	ASP109
E	ASP111
E	ASP306
E	MN502
E	JSQ504
E	HOH745
E	HOH751

---

site_id	AD5
Number of Residues	20
Details	binding site for residue JSQ E 504

Chain	Residue
A	ARG278
E	TYR54
E	ARG56
E	LYS77
E	ASP79
E	ASP109
E	ASP111
E	SER160
E	ARG162
E	ARG163
E	HIS166
E	HIS315
E	LEU316
E	LEU317
E	LYS318
E	HIS324
E	MN502
E	MN503
E	HOH647
E	HOH745

---

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO E 505

Chain	Residue
A	ASP149
A	PHE150
A	TYR188
E	THR349
E	SER351

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO E 506

Chain	Residue
E	ASP343
E	PHE345
A	SER173

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO E 507

Chain	Residue
E	PHE342
E	ASP343
E	THR346
E	VAL347
E	TYR391

---

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO E 508

Chain	Residue
A	SER205
E	LEU357
E	ASP358
E	HOH601
E	HOH629

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000255

Chain	Residue	Details
A	GLU44
A	ASP109
A	ASP111
E	GLU44
E	ASP109
E	ASP111

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:31479243, ECO:0007744|PDB:6R4S

Chain	Residue	Details
A	ASP109
A	ASP111
A	ASP306
E	ASP109
E	ASP111
E	ASP306

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:24043831, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377, ECO:0000269|PubMed:31479243

Chain	Residue	Details
A	CYS121
A	CYS122
A	CYS128
A	CYS131
E	CYS121
E	CYS122
E	CYS128
E	CYS131

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:24043831, ECO:0000269|PubMed:24239947, ECO:0000269|PubMed:31479243

Chain	Residue	Details
A	SER160
E	SER160

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:24043831, ECO:0000269|PubMed:31479243

Chain	Residue	Details
A	HIS315
E	HIS315

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:31479243

Chain	Residue	Details
A	HIS324
E	HIS324

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	MET1
E	MET1

---