6R5B
Crystal structure of PPEP-1(W103H/E143A/Y178F) in complex with substrate peptide Ac-EVNPPVP-CONH2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 |
| Chain | Residue | Details |
| A | ALA143 | |
| B | ALA143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 |
| Chain | Residue | Details |
| A | HIS142 | |
| A | HIS146 | |
| A | GLU185 | |
| B | HIS142 | |
| B | HIS146 | |
| B | GLU185 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 |
| Chain | Residue | Details |
| A | PHE178 | |
| B | PHE178 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Interacts with substrate peptide => ECO:0000269|PubMed:26211609 |
| Chain | Residue | Details |
| A | ASP135 | |
| A | HIS142 | |
| B | ASP135 | |
| B | HIS142 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:26211609 |
| Chain | Residue | Details |
| A | PHE178 | |
| B | PHE178 |
