6R54
Crystal structure of PPEP-1(E184A)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue TRS A 301 |
| Chain | Residue |
| A | HIS142 |
| A | GLU143 |
| A | HIS146 |
| A | TYR178 |
| A | GLU185 |
| A | ZN302 |
| A | HOH507 |
| A | HOH516 |
| A | HOH547 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU185 |
| A | TRS301 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NI A 303 |
| Chain | Residue |
| A | GLY23 |
| A | SER24 |
| A | HIS25 |
| A | MET26 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue TRS B 301 |
| Chain | Residue |
| A | SER24 |
| A | HIS25 |
| A | HOH529 |
| B | HIS142 |
| B | GLU143 |
| B | HIS146 |
| B | TYR178 |
| B | GLU185 |
| B | ZN302 |
| B | HOH419 |
| B | HOH492 |
| B | HOH514 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | HIS142 |
| B | HIS146 |
| B | GLU185 |
| B | TRS301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 |
| Chain | Residue | Details |
| A | GLU143 | |
| B | GLU143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 |
| Chain | Residue | Details |
| A | HIS142 | |
| A | HIS146 | |
| A | GLU185 | |
| B | HIS142 | |
| B | HIS146 | |
| B | GLU185 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 |
| Chain | Residue | Details |
| A | TYR178 | |
| B | TYR178 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Interacts with substrate peptide => ECO:0000269|PubMed:26211609 |
| Chain | Residue | Details |
| A | ASP135 | |
| A | HIS142 | |
| B | ASP135 | |
| B | HIS142 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:26211609 |
| Chain | Residue | Details |
| A | TYR178 | |
| B | TYR178 |
