6R4Y
Crystal structure of holo PPEP-1(E143A/Y178F) in complex with product peptide Ac-EVNP-CO2 (substrate peptide: Ac-EVNPAVP-CONH2)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0005576 | cellular_component | extracellular region |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 300 |
Chain | Residue |
A | HIS142 |
A | HIS146 |
A | GLU185 |
E | PRO4 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN B 300 |
Chain | Residue |
B | HIS142 |
B | HIS146 |
B | GLU185 |
D | PRO4 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for Di-peptide ACE D 0 and GLU D 1 |
Chain | Residue |
B | GLN32 |
B | GLY118 |
B | SER119 |
B | HIS150 |
B | HOH425 |
B | HOH492 |
D | VAL2 |
D | ASN3 |
D | HOH101 |
D | HOH103 |
B | THR30 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for Di-peptide ACE E 0 and GLU E 1 |
Chain | Residue |
A | GLY118 |
A | SER119 |
A | HIS150 |
A | GLN198 |
A | HOH422 |
A | HOH479 |
E | VAL2 |
E | ASN3 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609 |
Chain | Residue | Details |
A | ALA143 | |
B | ALA143 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609 |
Chain | Residue | Details |
A | HIS142 | |
A | HIS146 | |
A | GLU185 | |
B | HIS142 | |
B | HIS146 | |
B | GLU185 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339 |
Chain | Residue | Details |
A | PHE178 | |
B | PHE178 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | SITE: Interacts with substrate peptide => ECO:0000269|PubMed:26211609 |
Chain | Residue | Details |
A | ASP135 | |
A | HIS142 | |
B | ASP135 | |
B | HIS142 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:26211609 |
Chain | Residue | Details |
A | PHE178 | |
B | PHE178 |