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6R4X

Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVNPAVP-CONH2

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0046872molecular_functionmetal ion binding
B0005576cellular_componentextracellular region
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 301
ChainResidue
AHIS142
AHIS146
AGLU185
DPRO122

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN B 301
ChainResidue
BHIS142
BHIS146
BGLU185
CPRO122

site_idAC3
Number of Residues6
Detailsbinding site for Di-peptide ACE C 118 and GLU C 119
ChainResidue
BSER119
BHIS150
BHOH477
CVAL120
CASN121
BGLY118

site_idAC4
Number of Residues13
Detailsbinding site for Di-peptide VAL C 124 and LPD C 125
ChainResidue
AGLU104
AGLY105
BGLY102
BTRP103
BHIS134
BASP135
BALA136
BHIS142
BASN175
BPHE178
BHOH401
BHOH487
CALA123

site_idAC5
Number of Residues9
Detailsbinding site for Di-peptide ACE D 118 and GLU D 119
ChainResidue
AGLY118
ASER119
AHIS150
AASP155
ALYS158
AGLN198
AHOH422
DVAL120
DASN121

site_idAC6
Number of Residues11
Detailsbinding site for Di-peptide VAL D 124 and LPD D 125
ChainResidue
AGLY102
ATRP103
AHIS134
AASP135
AALA136
AHIS142
APHE178
AHOH406
DALA123
DHOH203
DHOH204

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000305|PubMed:24303041, ECO:0000305|PubMed:26211609
ChainResidueDetails
AALA143
BALA143

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339, ECO:0000269|PubMed:26211609
ChainResidueDetails
AHIS142
AHIS146
AGLU185
BHIS142
BHIS146
BGLU185

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01339
ChainResidueDetails
APHE178
BPHE178

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Interacts with substrate peptide => ECO:0000269|PubMed:26211609
ChainResidueDetails
AASP135
AHIS142
BASP135
BHIS142

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Transition state stabilizer => ECO:0000305|PubMed:26211609
ChainResidueDetails
APHE178
BPHE178

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PDB entries from 2024-07-24

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