6R4Q
Crystal structure of the periplasmic nickel-binding protein NikA from Escherichia coli in complex with Ru(bpza)CO H2O Cl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue FE A 601 |
| Chain | Residue |
| A | EDT602 |
| A | HOH701 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue EDT A 602 |
| Chain | Residue |
| A | FE601 |
| A | HOH701 |
| A | HOH766 |
| A | HOH865 |
| A | HOH911 |
| A | TYR22 |
| A | MET27 |
| A | ARG97 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | THR490 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 603 |
| Chain | Residue |
| A | GLU221 |
| A | GLY222 |
| A | LEU224 |
| A | LEU226 |
| A | HOH985 |
| A | HOH1055 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | LEU305 |
| A | LYS306 |
| A | THR456 |
| A | ASP460 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | GLN361 |
| A | ASP370 |
| A | SER372 |
| A | LEU373 |
| A | HOH846 |
| B | LYS157 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | GLN41 |
| A | ALA42 |
| A | ASP43 |
| A | HOH852 |
| A | HOH867 |
| B | GLN41 |
| B | ALA42 |
| B | PRO487 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | ARG95 |
| A | VAL108 |
| A | ASP109 |
| A | VAL110 |
| A | ASN281 |
| A | HOH1008 |
| A | HOH1012 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 608 |
| Chain | Residue |
| A | ALA99 |
| A | TRP100 |
| A | GLU102 |
| A | ASN105 |
| A | SER409 |
| A | SER410 |
| A | ARG412 |
| A | VAL413 |
| A | GOL615 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 609 |
| Chain | Residue |
| A | LYS257 |
| A | ALA258 |
| A | HOH708 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 610 |
| Chain | Residue |
| A | TRP10 |
| A | PRO11 |
| A | GLY219 |
| A | ASN220 |
| A | GLY222 |
| A | LEU223 |
| A | HOH728 |
| A | HOH839 |
| A | HOH909 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 611 |
| Chain | Residue |
| A | ARG68 |
| B | ACT611 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue ACT A 612 |
| Chain | Residue |
| A | LEU172 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 613 |
| Chain | Residue |
| A | LYS330 |
| A | ASP331 |
| A | ARG365 |
| B | LYS148 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 614 |
| Chain | Residue |
| A | LEU167 |
| A | GLN168 |
| A | HOH753 |
| B | THR211 |
| B | ASP213 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 615 |
| Chain | Residue |
| A | GLU102 |
| A | ASN105 |
| A | LYS123 |
| A | ASP227 |
| A | THR228 |
| A | ARG231 |
| A | ARG412 |
| A | GOL608 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 616 |
| Chain | Residue |
| A | LYS148 |
| A | ASN149 |
| A | LYS157 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 617 |
| Chain | Residue |
| A | ASN235 |
| A | ALA237 |
| A | PHE419 |
| A | GLN423 |
| A | PRO429 |
| A | HOH718 |
| A | HOH730 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 618 |
| Chain | Residue |
| A | LYS335 |
| B | ARG341 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 619 |
| Chain | Residue |
| A | GLN26 |
| A | ACT620 |
| A | HOH705 |
| A | THR23 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 620 |
| Chain | Residue |
| A | GLN26 |
| A | GOL619 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue RU B 601 |
| Chain | Residue |
| B | 6RP602 |
| B | CL603 |
| B | CMO604 |
| B | HOH703 |
| site_id | AE4 |
| Number of Residues | 11 |
| Details | binding site for residue 6RP B 602 |
| Chain | Residue |
| B | TYR22 |
| B | MET27 |
| B | TRP100 |
| B | ARG137 |
| B | TRP398 |
| B | TYR402 |
| B | RU601 |
| B | CL603 |
| B | CMO604 |
| B | HOH703 |
| B | HOH752 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 603 |
| Chain | Residue |
| B | RU601 |
| B | 6RP602 |
| B | CMO604 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue CMO B 604 |
| Chain | Residue |
| B | ARG137 |
| B | RU601 |
| B | 6RP602 |
| B | CL603 |
| B | GOL609 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | TRP10 |
| B | PRO11 |
| B | GLY219 |
| B | ASN220 |
| B | GLY222 |
| B | LEU223 |
| B | GOL610 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | GLU221 |
| B | VAL249 |
| B | SER353 |
| B | MET356 |
| B | PHE394 |
| B | ARG396 |
| B | HOH716 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 607 |
| Chain | Residue |
| A | ARG384 |
| A | ARG389 |
| B | LEU430 |
| B | ARG457 |
| B | HOH787 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 608 |
| Chain | Residue |
| A | LYS314 |
| A | ALA317 |
| A | LEU318 |
| A | LYS321 |
| B | GLU376 |
| B | ARG384 |
| B | HOH759 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 609 |
| Chain | Residue |
| B | TRP10 |
| B | GLN26 |
| B | MET27 |
| B | PHE28 |
| B | THR490 |
| B | CMO604 |
| B | HOH739 |
| site_id | AF3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 610 |
| Chain | Residue |
| B | ASN220 |
| B | GLU247 |
| B | ARG396 |
| B | ALA489 |
| B | THR490 |
| B | GOL605 |
| B | HOH727 |
| B | HOH947 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue ACT B 611 |
| Chain | Residue |
| A | ACT611 |
| B | ARG68 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 612 |
| Chain | Residue |
| A | HIS239 |
| B | TYR300 |
| B | GLN448 |
| B | HOH707 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 613 |
| Chain | Residue |
| A | ASP43 |
| B | GLN241 |
| B | ASN482 |
| B | PRO484 |
| B | TYR485 |
| B | HOH830 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 614 |
| Chain | Residue |
| B | PHE209 |
| B | GLU210 |
| B | GLY212 |
| B | ILE214 |
| B | LYS477 |
| B | HOH857 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
