6R4P
Structure of a soluble domain of adenylyl cyclase bound to an activated stimulatory G protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0004016 | molecular_function | adenylate cyclase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006171 | biological_process | cAMP biosynthetic process |
| A | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 0008218 | biological_process | bioluminescence |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071880 | biological_process | adenylate cyclase-activating adrenergic receptor signaling pathway |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0019001 | molecular_function | guanyl nucleotide binding |
| B | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue GSP B 501 |
| Chain | Residue |
| B | GLY49 |
| B | ARG201 |
| B | THR204 |
| B | GLY226 |
| B | ASN292 |
| B | LYS293 |
| B | ASP295 |
| B | LEU296 |
| B | CYS365 |
| B | ALA366 |
| B | VAL367 |
| B | GLU50 |
| B | MG502 |
| B | SER51 |
| B | GLY52 |
| B | LYS53 |
| B | SER54 |
| B | THR55 |
| B | LEU198 |
| B | ARG199 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 502 |
| Chain | Residue |
| B | SER54 |
| B | THR204 |
| B | GSP501 |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GIL.GmrrfkFdVWSNDVNlanlmE |
| Chain | Residue | Details |
| A | GLY498-GLU521 | |
| A | GLY1176-ASP1199 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641 |
| Chain | Residue | Details |
| B | GLY47 | |
| B | LEU198 | |
| B | VAL224 | |
| B | LYS293 | |
| B | VAL367 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715 |
| Chain | Residue | Details |
| B | SER54 | |
| B | SER205 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63092 |
| Chain | Residue | Details |
| B | GLY353 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | LIPID: N-palmitoyl glycine => ECO:0000269|PubMed:12574119 |
| Chain | Residue | Details |
| B | GLY2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:12574119 |
| Chain | Residue | Details |
| B | CYS3 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P63092 |
| Chain | Residue | Details |
| B | VAL301 |
