Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| C | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| C | 0005524 | molecular_function | ATP binding |
| C | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
Functional Information from PDB Data
| site_id | ACA |
| Number of Residues | 5 |
| Details | ACTIVE SITE WITH GLUTAMATE 441 MUTATED TO ASPARTATE. |
| Chain | Residue |
| A | CYS225 |
| A | CYS462 |
| A | CYS439 |
| A | ASN437 |
| A | ASP441 |
| site_id | ACB |
| Number of Residues | 5 |
| Details | ACTIVE SITE WITH GLUTAMATE 441 MUTATED TO ASPARTATE. |
| Chain | Residue |
| B | ASP441 |
| B | CYS225 |
| B | CYS462 |
| B | CYS439 |
| B | ASN437 |
| site_id | ACC |
| Number of Residues | 5 |
| Details | ACTIVE SITE WITH GLUTAMATE 441 MUTATED TO ASPARTATE. |
| Chain | Residue |
| C | CYS225 |
| C | CYS462 |
| C | CYS439 |
| C | ASN437 |
| C | ASP441 |
Functional Information from PROSITE/UniProt
| site_id | PS00089 |
| Number of Residues | 23 |
| Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WeaLresikthGLRNstlSAlmP |
| Chain | Residue | Details |
| A | TRP599-PRO621 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | ASN437 | |
| A | ASP441 | |
| B | ASN437 | |
| B | ASP441 | |
| C | ASN437 | |
| C | ASP441 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | ACT_SITE: Cysteine radical intermediate |
| Chain | Residue | Details |
| A | CYS439 | |
| B | CYS439 | |
| C | CYS439 | |
| Chain | Residue | Details |
| A | LYS9 | |
| C | GLU15 | |
| C | THR55 | |
| C | LYS91 | |
| A | GLU15 | |
| A | THR55 | |
| A | LYS91 | |
| B | LYS9 | |
| B | GLU15 | |
| B | THR55 | |
| B | LYS91 | |
| C | LYS9 | |
| Chain | Residue | Details |
| A | THR209 | |
| B | ARG262 | |
| B | ARG269 | |
| B | ASN437 | |
| B | ASP441 | |
| B | GLU623 | |
| C | THR209 | |
| C | ASP232 | |
| C | ARG262 | |
| C | ARG269 | |
| C | ASN437 | |
| A | ASP232 | |
| C | ASP441 | |
| C | GLU623 | |
| A | ARG262 | |
| A | ARG269 | |
| A | ASN437 | |
| A | ASP441 | |
| A | GLU623 | |
| B | THR209 | |
| B | ASP232 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Important for hydrogen atom transfer |
| Chain | Residue | Details |
| A | CYS225 | |
| A | CYS462 | |
| B | CYS225 | |
| B | CYS462 | |
| C | CYS225 | |
| C | CYS462 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Important for electron transfer |
| Chain | Residue | Details |
| A | TYR730 | |
| A | TYR731 | |
| B | TYR730 | |
| B | TYR731 | |
| C | TYR730 | |
| C | TYR731 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | SITE: Interacts with thioredoxin/glutaredoxin |
| Chain | Residue | Details |
| A | CYS754 | |
| A | CYS759 | |
| B | CYS754 | |
| B | CYS759 | |
| C | CYS754 | |
| C | CYS759 | |
| Chain | Residue | Details |
| A | LYS283 | |
| B | LYS283 | |
| C | LYS283 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 3r1r |
| Chain | Residue | Details |
| A | ASP441 | |
| A | CYS462 | |
| A | CYS439 | |
| A | CYS225 | |
| A | ASN437 | |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 3r1r |
| Chain | Residue | Details |
| B | ASP441 | |
| B | CYS462 | |
| B | CYS439 | |
| B | CYS225 | |
| B | ASN437 | |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 3r1r |
| Chain | Residue | Details |
| C | ASP441 | |
| C | CYS462 | |
| C | CYS439 | |
| C | CYS225 | |
| C | ASN437 | |
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 918 |
| Chain | Residue | Details |
| A | CYS225 | proton donor |
| A | ASN437 | |
| A | CYS439 | hydrogen radical acceptor, hydrogen radical donor, single electron acceptor |
| A | ASP441 | proton acceptor |
| A | CYS462 | |
| A | TYR730 | pi-pi interaction, single electron relay |
| A | TYR731 | pi-pi interaction, single electron relay |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 918 |
| Chain | Residue | Details |
| B | CYS225 | proton donor |
| B | ASN437 | |
| B | CYS439 | hydrogen radical acceptor, hydrogen radical donor, single electron acceptor |
| B | ASP441 | proton acceptor |
| B | CYS462 | |
| B | TYR730 | pi-pi interaction, single electron relay |
| B | TYR731 | pi-pi interaction, single electron relay |
| site_id | MCSA3 |
| Number of Residues | |
| Details | M-CSA 918 |
| Chain | Residue | Details |
| C | CYS225 | proton donor |
| C | ASN437 | |
| C | CYS439 | hydrogen radical acceptor, hydrogen radical donor, single electron acceptor |
| C | ASP441 | proton acceptor |
| C | CYS462 | |
| C | TYR730 | pi-pi interaction, single electron relay |
| C | TYR731 | pi-pi interaction, single electron relay |
| site_id | MCSA4 |
| Number of Residues | |
| Details | M-CSA 918 |
