6QZJ

Crystal structure of human Aquaporin 7 at 2.2 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 501

Chain	Residue
A	TYR67
A	GLY222
A	TYR223
A	ARG229
A	GOL511

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	VAL82
A	GLY90
A	HOH607

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 503

Chain	Residue
A	PHE187
A	THR190
A	ASP191
A	ARG106

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 504

Chain	Residue
A	TRP177
A	GLY180
A	GLY268

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 505

Chain	Residue
A	ALA91
A	HIS92
A	ASN94
A	GOL506
A	HOH605
A	HOH607

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 506

Chain	Residue
A	HIS92
A	MET93
A	ASN94
A	ASN226
A	GOL505
A	GOL511
A	HOH605
A	HOH611

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL A 507

Chain	Residue
A	ARG35
A	GLU193
A	ASN194

---

site_id	AC8
Number of Residues	10
Details	binding site for residue GOL A 508

Chain	Residue
A	PRO108
A	ARG110
A	LEU162
A	PRO163
A	ASP164
A	MET166
A	ASN249
A	GLY250
A	GLU251
A	HOH606

---

site_id	AC9
Number of Residues	1
Details	binding site for residue GOL A 509

Chain	Residue
A	ASP164

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL A 510

Chain	Residue
A	SER132
A	TRP169
A	ARG170

---

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL A 511

Chain	Residue
A	PHE74
A	GLY222
A	TYR223
A	ALA224
A	ARG229
A	GOL501
A	GOL506
A	HOH611

---

site_id	AD3
Number of Residues	1
Details	binding site for residue PO4 A 512

Chain	Residue
A	TRP255

---

site_id	AD4
Number of Residues	3
Details	binding site for residue PO4 A 513

Chain	Residue
A	LYS244
A	ASN252
A	TRP254

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	69
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Site: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Site: {"description":"Important for permeability to glycerol","evidences":[{"source":"PubMed","id":"30423801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---