6QZI

Crystal structure of human Aquaporin 7 at 1.9 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 301

Chain	Residue
A	GLY86
A	GLY90
A	ASN195
A	GLU202
A	HOH402

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 302

Chain	Residue
A	ARG229
A	GOL308
A	GOL312
A	HOH405
A	PHE74
A	GLY222
A	TYR223
A	ALA224

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 303

Chain	Residue
A	LEU60
A	ASN61
A	ALA137
A	HIS140
A	HIS165
A	MET219

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 304

Chain	Residue
A	ALA103
A	TRP109
A	THR149
A	HOH406

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 305

Chain	Residue
A	ARG35
A	GLU193
A	ILE276
A	THR279

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 306

Chain	Residue
A	GLY156
A	ALA159
A	THR160
A	TYR161
A	GOL308
A	HOH425

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL A 307

Chain	Residue
A	MET58
A	VAL59
A	ASN61
A	LYS62
A	PHE141
A	HOH417

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL A 308

Chain	Residue
A	VAL55
A	VAL70
A	GLY222
A	ARG229
A	GOL302
A	GOL306
A	HOH403

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL A 309

Chain	Residue
A	LYS62
A	GLY65
A	SER66
A	SER66
A	TYR67
A	LEU68
A	HOH416

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL A 310

Chain	Residue
A	SER132
A	TYR135
A	ARG170

---

site_id	AD2
Number of Residues	3
Details	binding site for residue GOL A 311

Chain	Residue
A	ARG106
A	THR190
A	ASP191

---

site_id	AD3
Number of Residues	9
Details	binding site for residue GOL A 312

Chain	Residue
A	VAL78
A	HIS92
A	ASN94
A	ASN226
A	GOL302
A	GOL313
A	HOH401
A	HOH404
A	HOH405

---

site_id	AD4
Number of Residues	10
Details	binding site for residue GOL A 313

Chain	Residue
A	ALA91
A	HIS92
A	MET93
A	ASN94
A	LEU182
A	LEU186
A	GOL312
A	HOH401
A	HOH404
A	HOH434

---

site_id	AD5
Number of Residues	3
Details	binding site for residue GOL A 314

Chain	Residue
A	ARG110
A	HIS140
A	HIS165

---

site_id	AD6
Number of Residues	5
Details	binding site for residue PO4 A 315

Chain	Residue
A	LEU146
A	GLY241
A	TRP242
A	GLY243
A	GLN245

---

site_id	AD7
Number of Residues	3
Details	binding site for residue PO4 A 316

Chain	Residue
A	LEU198
A	GLY200
A	HOH428

---

site_id	AD8
Number of Residues	2
Details	binding site for residue PO4 A 317

Chain	Residue
A	PHE247
A	ASN252

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	69
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	Site: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Site: {"description":"Important for permeability to glycerol","evidences":[{"source":"PubMed","id":"30423801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---