6QY8

Human CSNK2A2 bound to ERB-041

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0001669	cellular_component	acrosomal vesicle
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006302	biological_process	double-strand break repair
A	0006351	biological_process	DNA-templated transcription
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007283	biological_process	spermatogenesis
A	0016055	biological_process	Wnt signaling pathway
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0021987	biological_process	cerebral cortex development
A	0031507	biological_process	heterochromatin formation
A	0031519	cellular_component	PcG protein complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0042176	biological_process	regulation of protein catabolic process
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0097421	biological_process	liver regeneration
A	0106310	molecular_function	protein serine kinase activity
A	1901524	biological_process	regulation of mitophagy
A	1903955	biological_process	obsolete positive regulation of protein targeting to mitochondrion
A	1905818	biological_process	regulation of chromosome separation
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
B	0000166	molecular_function	nucleotide binding
B	0000785	cellular_component	chromatin
B	0001669	cellular_component	acrosomal vesicle
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005956	cellular_component	protein kinase CK2 complex
B	0006302	biological_process	double-strand break repair
B	0006351	biological_process	DNA-templated transcription
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0007283	biological_process	spermatogenesis
B	0016055	biological_process	Wnt signaling pathway
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0021987	biological_process	cerebral cortex development
B	0031507	biological_process	heterochromatin formation
B	0031519	cellular_component	PcG protein complex
B	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
B	0042176	biological_process	regulation of protein catabolic process
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0097421	biological_process	liver regeneration
B	0106310	molecular_function	protein serine kinase activity
B	1901524	biological_process	regulation of mitophagy
B	1903955	biological_process	obsolete positive regulation of protein targeting to mitochondrion
B	1905818	biological_process	regulation of chromosome separation
B	2001234	biological_process	negative regulation of apoptotic signaling pathway
C	0000166	molecular_function	nucleotide binding
C	0000785	cellular_component	chromatin
C	0001669	cellular_component	acrosomal vesicle
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005956	cellular_component	protein kinase CK2 complex
C	0006302	biological_process	double-strand break repair
C	0006351	biological_process	DNA-templated transcription
C	0006468	biological_process	protein phosphorylation
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0007283	biological_process	spermatogenesis
C	0016055	biological_process	Wnt signaling pathway
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0021987	biological_process	cerebral cortex development
C	0031507	biological_process	heterochromatin formation
C	0031519	cellular_component	PcG protein complex
C	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0042176	biological_process	regulation of protein catabolic process
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0097421	biological_process	liver regeneration
C	0106310	molecular_function	protein serine kinase activity
C	1901524	biological_process	regulation of mitophagy
C	1903955	biological_process	obsolete positive regulation of protein targeting to mitochondrion
C	1905818	biological_process	regulation of chromosome separation
C	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0000166	molecular_function	nucleotide binding
D	0000785	cellular_component	chromatin
D	0001669	cellular_component	acrosomal vesicle
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005956	cellular_component	protein kinase CK2 complex
D	0006302	biological_process	double-strand break repair
D	0006351	biological_process	DNA-templated transcription
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0016055	biological_process	Wnt signaling pathway
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0021987	biological_process	cerebral cortex development
D	0031507	biological_process	heterochromatin formation
D	0031519	cellular_component	PcG protein complex
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0042176	biological_process	regulation of protein catabolic process
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0097421	biological_process	liver regeneration
D	0106310	molecular_function	protein serine kinase activity
D	1901524	biological_process	regulation of mitophagy
D	1903955	biological_process	obsolete positive regulation of protein targeting to mitochondrion
D	1905818	biological_process	regulation of chromosome separation
D	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 041 A 500

Chain	Residue
A	LYS69
A	HOH686
A	PHE114
A	ILE117
A	ASN119
A	MET164
A	ILE175
A	ASP176
A	HOH619
A	HOH665

---

site_id	AC2
Number of Residues	12
Details	binding site for residue 041 B 500

Chain	Residue
B	LEU46
B	VAL54
B	LYS69
B	PHE114
B	ILE117
B	ASN119
B	MET164
B	ILE175
B	ASP176
B	HOH624
B	HOH659
B	HOH682

---

site_id	AC3
Number of Residues	11
Details	binding site for residue 041 C 500

Chain	Residue
C	VAL54
C	LYS69
C	PHE114
C	ILE117
C	ASN119
C	MET164
C	ILE175
C	ASP176
C	HOH644
C	HOH654
C	HOH667

---

site_id	AC4
Number of Residues	12
Details	binding site for residue 041 D 500

Chain	Residue
D	LEU46
D	VAL54
D	LYS69
D	PHE114
D	ILE117
D	ASN119
D	MET164
D	ILE175
D	ASP176
D	HOH607
D	HOH667
D	HOH680

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK

Chain	Residue	Details
A	LEU46-LYS69

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE153-ILE165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	285
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---