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6QY8

Human CSNK2A2 bound to ERB-041

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001669cellular_componentacrosomal vesicle
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005956cellular_componentprotein kinase CK2 complex
A0006302biological_processdouble-strand break repair
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0007283biological_processspermatogenesis
A0016055biological_processWnt signaling pathway
A0021987biological_processcerebral cortex development
A0031519cellular_componentPcG protein complex
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0051726biological_processregulation of cell cycle
A0097421biological_processliver regeneration
A0106310molecular_functionprotein serine kinase activity
A1901524biological_processregulation of mitophagy
A1903955biological_processpositive regulation of protein targeting to mitochondrion
A1905818biological_processregulation of chromosome separation
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0000785cellular_componentchromatin
B0001669cellular_componentacrosomal vesicle
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005956cellular_componentprotein kinase CK2 complex
B0006302biological_processdouble-strand break repair
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0007283biological_processspermatogenesis
B0016055biological_processWnt signaling pathway
B0021987biological_processcerebral cortex development
B0031519cellular_componentPcG protein complex
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0051726biological_processregulation of cell cycle
B0097421biological_processliver regeneration
B0106310molecular_functionprotein serine kinase activity
B1901524biological_processregulation of mitophagy
B1903955biological_processpositive regulation of protein targeting to mitochondrion
B1905818biological_processregulation of chromosome separation
B2001234biological_processnegative regulation of apoptotic signaling pathway
C0000785cellular_componentchromatin
C0001669cellular_componentacrosomal vesicle
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005956cellular_componentprotein kinase CK2 complex
C0006302biological_processdouble-strand break repair
C0006468biological_processprotein phosphorylation
C0006915biological_processapoptotic process
C0007283biological_processspermatogenesis
C0016055biological_processWnt signaling pathway
C0021987biological_processcerebral cortex development
C0031519cellular_componentPcG protein complex
C0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
C0051726biological_processregulation of cell cycle
C0097421biological_processliver regeneration
C0106310molecular_functionprotein serine kinase activity
C1901524biological_processregulation of mitophagy
C1903955biological_processpositive regulation of protein targeting to mitochondrion
C1905818biological_processregulation of chromosome separation
C2001234biological_processnegative regulation of apoptotic signaling pathway
D0000785cellular_componentchromatin
D0001669cellular_componentacrosomal vesicle
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005956cellular_componentprotein kinase CK2 complex
D0006302biological_processdouble-strand break repair
D0006468biological_processprotein phosphorylation
D0006915biological_processapoptotic process
D0007283biological_processspermatogenesis
D0016055biological_processWnt signaling pathway
D0021987biological_processcerebral cortex development
D0031519cellular_componentPcG protein complex
D0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
D0051726biological_processregulation of cell cycle
D0097421biological_processliver regeneration
D0106310molecular_functionprotein serine kinase activity
D1901524biological_processregulation of mitophagy
D1903955biological_processpositive regulation of protein targeting to mitochondrion
D1905818biological_processregulation of chromosome separation
D2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 041 A 500
ChainResidue
ALYS69
AHOH686
APHE114
AILE117
AASN119
AMET164
AILE175
AASP176
AHOH619
AHOH665

site_idAC2
Number of Residues12
Detailsbinding site for residue 041 B 500
ChainResidue
BLEU46
BVAL54
BLYS69
BPHE114
BILE117
BASN119
BMET164
BILE175
BASP176
BHOH624
BHOH659
BHOH682

site_idAC3
Number of Residues11
Detailsbinding site for residue 041 C 500
ChainResidue
CVAL54
CLYS69
CPHE114
CILE117
CASN119
CMET164
CILE175
CASP176
CHOH644
CHOH654
CHOH667

site_idAC4
Number of Residues12
Detailsbinding site for residue 041 D 500
ChainResidue
DLEU46
DVAL54
DLYS69
DPHE114
DILE117
DASN119
DMET164
DILE175
DASP176
DHOH607
DHOH667
DHOH680

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK
ChainResidueDetails
ALEU46-LYS69

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
AILE153-ILE165

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP157
BASP157
CASP157
DASP157

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALYS69
BLEU46
BLYS69
CLEU46
CLYS69
DLEU46
DLYS69
ALEU46

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
BTYR13
CTYR13
DTYR13
ATYR13

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER18
CSER18
DSER18
ASER18

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
ChainResidueDetails
CSER21
CSER288
DSER21
DSER288
ASER21
ASER288
BSER21
BSER288

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS97
BLYS97
CLYS97
DLYS97

221051

PDB entries from 2024-06-12

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