6QVW
Solution structure of the free FOXO1 DNA binding domain
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00658 |
| Number of Residues | 7 |
| Details | FORK_HEAD_2 Fork head domain signature 2. WKNSIRH |
| Chain | Residue | Details |
| A | TRP206-HIS212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | DNA_BIND: Fork-head => ECO:0000255|PROSITE-ProRule:PRU00089 |
| Chain | Residue | Details |
| A | ALA156-SER232 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: DNA-binding => ECO:0000269|PubMed:18786403 |
| Chain | Residue | Details |
| A | TYR162 | |
| A | ARG222 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:21245099 |
| Chain | Residue | Details |
| A | SER209 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403 |
| Chain | Residue | Details |
| A | SER215 | |
| A | SER231 | |
| A | SER232 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9R1E0 |
| Chain | Residue | Details |
| A | LYS242 | |
| A | LYS245 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:18356527 |
| Chain | Residue | Details |
| A | SER246 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Omega-N-methylarginine; by PRMT1 => ECO:0000250|UniProtKB:Q9R1E0 |
| Chain | Residue | Details |
| A | ARG248 | |
| A | ARG250 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKB/AKT1 and SGK1 => ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:11237865, ECO:0000269|PubMed:11980723, ECO:0000269|PubMed:31063815 |
| Chain | Residue | Details |
| A | SER253 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20543840 |
| Chain | Residue | Details |
| A | LYS259 | |
| A | LYS262 |
