6QVW

Solution structure of the free FOXO1 DNA binding domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WKNSIRH

Chain	Residue	Details
A	TRP206-HIS212

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA binding: {"description":"Fork-head","evidences":[{"source":"PROSITE-ProRule","id":"PRU00089","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Motif: {"description":"Nuclear localization signal"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by STK4/MST1","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19221179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21245099","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by STK4/MST1","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9R1E0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"18356527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine; by PRMT1","evidences":[{"source":"UniProtKB","id":"Q9R1E0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKB/AKT1 and SGK1","evidences":[{"source":"PubMed","id":"10358075","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10358076","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11237865","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11980723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28851713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31063815","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20543840","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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