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6QVC

CryoEM structure of the human ClC-1 chloride channel, CBS state 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005247molecular_functionvoltage-gated chloride channel activity
A0005254molecular_functionchloride channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006821biological_processchloride transport
A0006936biological_processmuscle contraction
A0016020cellular_componentmembrane
A0019227biological_processneuronal action potential propagation
A0030315cellular_componentT-tubule
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0042383cellular_componentsarcolemma
A0042803molecular_functionprotein homodimerization activity
A0055085biological_processtransmembrane transport
A1902476biological_processchloride transmembrane transport
B0005247molecular_functionvoltage-gated chloride channel activity
B0005254molecular_functionchloride channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006821biological_processchloride transport
B0006936biological_processmuscle contraction
B0016020cellular_componentmembrane
B0019227biological_processneuronal action potential propagation
B0030315cellular_componentT-tubule
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0042383cellular_componentsarcolemma
B0042803molecular_functionprotein homodimerization activity
B0055085biological_processtransmembrane transport
B1902476biological_processchloride transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1170
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
BMET1-GLY118
ATHR196-THR208
ASER247-THR268
AGLU291-ASN301
AARG377-ARG390
AASP579-LEU988
BHIS180-SER183
BTHR196-THR208
BSER247-THR268
BGLU291-ASN301
BARG377-ARG390
BASP579-LEU988
AMET1-GLY118
AHIS180-SER183

site_idSWS_FT_FI2
Number of Residues230
DetailsTRANSMEM: Helical => ECO:0000305|PubMed:29809153, ECO:0000305|PubMed:31022181, ECO:0000305|PubMed:37892996, ECO:0007744|PDB:6COY, ECO:0007744|PDB:6QV6
ChainResidueDetails
BILE119-TYR150
ALEU391-PRO408
BLEU159-CYS179
BTYR302-VAL321
BLEU348-VAL376
BLEU391-PRO408
AILE119-TYR150
ALEU159-CYS179
ATYR302-VAL321
ALEU348-VAL376

site_idSWS_FT_FI3
Number of Residues182
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
BALA151-PRO158
ALEU427-VAL457
AGLY499-PRO521
AHIS555-LEU557
BTRP322-GLU347
BGLY409-MET414
BLEU427-VAL457
BGLY499-PRO521
BHIS555-LEU557
AALA151-PRO158
ATRP322-GLU347
AGLY409-MET414

site_idSWS_FT_FI4
Number of Residues46
DetailsINTRAMEM: Note=Loop between two helices => ECO:0000305|PubMed:29809153, ECO:0000305|PubMed:31022181, ECO:0000305|PubMed:37892996, ECO:0007744|PDB:6COY, ECO:0007744|PDB:6QV6
ChainResidueDetails
BPRO184-SER189
ATHR476-GLY482
ATHR539-VAL540
ASER572-PRO575
BSER225-GLY230
BALA415-LEU418
BTHR476-GLY482
BTHR539-VAL540
BSER572-PRO575
APRO184-SER189
ASER225-GLY230
AALA415-LEU418

site_idSWS_FT_FI5
Number of Residues276
DetailsINTRAMEM: Helical => ECO:0000305|PubMed:29809153, ECO:0000305|PubMed:31022181, ECO:0000305|PubMed:37892996, ECO:0007744|PDB:6COY, ECO:0007744|PDB:6QV6
ChainResidueDetails
BGLY190-LYS195
BSER541-ALA554
BPRO558-GLN571
BSER576-TYR578
AGLY190-LYS195
AMET209-GLY224
ALYS231-LEU246
AVAL269-GLY280
ATHR281-ILE290
AMET419-THR426
AILE458-THR475
BMET209-GLY224
AGLY483-VAL498
AGLY522-HIS538
ASER541-ALA554
APRO558-GLN571
ASER576-TYR578
BLYS231-LEU246
BVAL269-GLY280
BTHR281-ILE290
BMET419-THR426
BILE458-THR475
BGLY483-VAL498
BGLY522-HIS538

site_idSWS_FT_FI6
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P37019
ChainResidueDetails
BSER189
BPHE484
BTYR578
ASER189
APHE484
ATYR578

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Protopore gate => ECO:0000305|PubMed:29809153
ChainResidueDetails
BGLU232
AGLU232

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q64347
ChainResidueDetails
BSER886
ASER886

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PDB entries from 2024-11-06

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