6QV6
CryoEM structure of the human ClC-1 chloride channel, membrane domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005247 | molecular_function | voltage-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006936 | biological_process | muscle contraction |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019227 | biological_process | neuronal action potential propagation |
| A | 0030315 | cellular_component | T-tubule |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034707 | cellular_component | chloride channel complex |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005247 | molecular_function | voltage-gated chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006936 | biological_process | muscle contraction |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019227 | biological_process | neuronal action potential propagation |
| B | 0030315 | cellular_component | T-tubule |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0034707 | cellular_component | chloride channel complex |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 230 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29809153","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31022181","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37892996","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6COY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QV6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 182 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 76 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | Intramembrane: {"description":"Note=Loop between two helices","evidences":[{"source":"PubMed","id":"29809153","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31022181","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37892996","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6COY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QV6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 276 |
| Details | Intramembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29809153","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31022181","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37892996","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6COY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QV6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P37019","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Protopore gate","evidences":[{"source":"PubMed","id":"29809153","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
