6QUY

NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003725	molecular_function	double-stranded RNA binding
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030182	biological_process	neuron differentiation
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0051301	biological_process	cell division
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003725	molecular_function	double-stranded RNA binding
C	0003924	molecular_function	GTPase activity
C	0005198	molecular_function	structural molecule activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0005929	cellular_component	cilium
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030182	biological_process	neuron differentiation
C	0030705	biological_process	cytoskeleton-dependent intracellular transport
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0051301	biological_process	cell division
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0003924	molecular_function	GTPase activity
G	0005198	molecular_function	structural molecule activity
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005641	cellular_component	nuclear envelope lumen
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005929	cellular_component	cilium
G	0007017	biological_process	microtubule-based process
G	0015630	cellular_component	microtubule cytoskeleton
G	0019904	molecular_function	protein domain specific binding
G	0030705	biological_process	cytoskeleton-dependent intracellular transport
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032794	molecular_function	GTPase activating protein binding
G	0032991	cellular_component	protein-containing complex
G	0035578	cellular_component	azurophil granule lumen
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042267	biological_process	natural killer cell mediated cytotoxicity
G	0042288	molecular_function	MHC class I protein binding
G	0044297	cellular_component	cell body
G	0044877	molecular_function	protein-containing complex binding
G	0045121	cellular_component	membrane raft
G	0045171	cellular_component	intercellular bridge
G	0046872	molecular_function	metal ion binding
G	0050807	biological_process	regulation of synapse organization
G	0051301	biological_process	cell division
G	0070062	cellular_component	extracellular exosome
G	0071895	biological_process	odontoblast differentiation
G	0072686	cellular_component	mitotic spindle
G	0097228	cellular_component	sperm principal piece
G	0097229	cellular_component	sperm end piece
G	0097542	cellular_component	ciliary tip
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0003924	molecular_function	GTPase activity
H	0005198	molecular_function	structural molecule activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005641	cellular_component	nuclear envelope lumen
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007017	biological_process	microtubule-based process
H	0015630	cellular_component	microtubule cytoskeleton
H	0019904	molecular_function	protein domain specific binding
H	0030705	biological_process	cytoskeleton-dependent intracellular transport
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032794	molecular_function	GTPase activating protein binding
H	0032991	cellular_component	protein-containing complex
H	0035578	cellular_component	azurophil granule lumen
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042267	biological_process	natural killer cell mediated cytotoxicity
H	0042288	molecular_function	MHC class I protein binding
H	0044297	cellular_component	cell body
H	0044877	molecular_function	protein-containing complex binding
H	0045121	cellular_component	membrane raft
H	0045171	cellular_component	intercellular bridge
H	0046872	molecular_function	metal ion binding
H	0050807	biological_process	regulation of synapse organization
H	0051301	biological_process	cell division
H	0070062	cellular_component	extracellular exosome
H	0071895	biological_process	odontoblast differentiation
H	0072686	cellular_component	mitotic spindle
H	0097228	cellular_component	sperm principal piece
H	0097229	cellular_component	sperm end piece
H	0097542	cellular_component	ciliary tip
W	0005516	molecular_function	calmodulin binding
W	0008017	molecular_function	microtubule binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue GTP A 501

Chain	Residue
A	GLN11
A	THR145
A	GLY146
A	ILE171
A	THR179
A	ASN206
A	TYR224
A	ASN228
A	ILE231
A	MG502
H	LYS254
A	ALA12
A	GLN15
A	GLU71
A	ASP98
A	ASN101
A	SER140
A	GLY143
A	GLY144

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 502

Chain	Residue
A	GLN11
A	GTP501

---

site_id	AC3
Number of Residues	19
Details	binding site for residue GTP C 501

Chain	Residue
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	GLU71
C	ASP98
C	ALA100
C	ASN101
C	SER140
C	GLY142
C	GLY143
C	GLY144
C	THR145
C	THR179
C	ASN206
C	TYR224
C	ASN228
C	MG502
G	LYS254

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG C 502

Chain	Residue
C	GLU71
C	GTP501

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GDP H 501

Chain	Residue
H	GLN11
H	CYS12
H	GLN15
H	GLY143
H	GLY144
H	THR145
H	GLY146
H	TYR224
H	ASN228

---

site_id	AC6
Number of Residues	12
Details	binding site for residue TA1 H 502

Chain	Residue
H	GLU22
H	VAL23
H	ASP26
H	GLU27
H	HIS229
H	ALA233
H	SER236
H	THR276
H	ARG278
H	GLN281
H	ARG369
H	LEU371

---

site_id	AC7
Number of Residues	10
Details	binding site for residue GDP G 501

Chain	Residue
G	GLN11
G	CYS12
G	GLN15
G	GLY143
G	GLY144
G	THR145
G	GLY146
G	ASN206
G	TYR224
G	ASN228

---

site_id	AC8
Number of Residues	13
Details	binding site for residue TA1 G 502

Chain	Residue
G	GLU22
G	VAL23
G	ASP26
G	GLU27
G	ASP226
G	HIS229
G	ALA233
G	SER236
G	THR276
G	ARG278
G	GLN281
G	ARG369
G	LEU371

---

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
H	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
H	MET1-ILE4

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Motif: {"description":"MREC motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Motif: {"description":"MREI motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Campbell A.","Ozanne B.W.","Lourenco F.","Olson M.F."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"}

Chain

Residue

Details

---