6QUS
HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| I | 0005516 | molecular_function | calmodulin binding |
| I | 0008017 | molecular_function | microtubule binding |
| O | 0000166 | molecular_function | nucleotide binding |
| O | 0000226 | biological_process | microtubule cytoskeleton organization |
| O | 0000278 | biological_process | mitotic cell cycle |
| O | 0003725 | molecular_function | double-stranded RNA binding |
| O | 0003924 | molecular_function | GTPase activity |
| O | 0005198 | molecular_function | structural molecule activity |
| O | 0005200 | molecular_function | structural constituent of cytoskeleton |
| O | 0005515 | molecular_function | protein binding |
| O | 0005525 | molecular_function | GTP binding |
| O | 0005737 | cellular_component | cytoplasm |
| O | 0005856 | cellular_component | cytoskeleton |
| O | 0005874 | cellular_component | microtubule |
| O | 0005881 | cellular_component | cytoplasmic microtubule |
| O | 0005929 | cellular_component | cilium |
| O | 0007017 | biological_process | microtubule-based process |
| O | 0015630 | cellular_component | microtubule cytoskeleton |
| O | 0016787 | molecular_function | hydrolase activity |
| O | 0030182 | biological_process | neuron differentiation |
| O | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| O | 0031625 | molecular_function | ubiquitin protein ligase binding |
| O | 0051301 | biological_process | cell division |
| S | 0000166 | molecular_function | nucleotide binding |
| S | 0000226 | biological_process | microtubule cytoskeleton organization |
| S | 0000278 | biological_process | mitotic cell cycle |
| S | 0003924 | molecular_function | GTPase activity |
| S | 0005198 | molecular_function | structural molecule activity |
| S | 0005200 | molecular_function | structural constituent of cytoskeleton |
| S | 0005515 | molecular_function | protein binding |
| S | 0005525 | molecular_function | GTP binding |
| S | 0005576 | cellular_component | extracellular region |
| S | 0005634 | cellular_component | nucleus |
| S | 0005641 | cellular_component | nuclear envelope lumen |
| S | 0005737 | cellular_component | cytoplasm |
| S | 0005829 | cellular_component | cytosol |
| S | 0005856 | cellular_component | cytoskeleton |
| S | 0005874 | cellular_component | microtubule |
| S | 0005929 | cellular_component | cilium |
| S | 0007017 | biological_process | microtubule-based process |
| S | 0015630 | cellular_component | microtubule cytoskeleton |
| S | 0019904 | molecular_function | protein domain specific binding |
| S | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| S | 0031625 | molecular_function | ubiquitin protein ligase binding |
| S | 0032794 | molecular_function | GTPase activating protein binding |
| S | 0032991 | cellular_component | protein-containing complex |
| S | 0035578 | cellular_component | azurophil granule lumen |
| S | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| S | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| S | 0042288 | molecular_function | MHC class I protein binding |
| S | 0044297 | cellular_component | cell body |
| S | 0044877 | molecular_function | protein-containing complex binding |
| S | 0045121 | cellular_component | membrane raft |
| S | 0045171 | cellular_component | intercellular bridge |
| S | 0046872 | molecular_function | metal ion binding |
| S | 0050807 | biological_process | regulation of synapse organization |
| S | 0051301 | biological_process | cell division |
| S | 0070062 | cellular_component | extracellular exosome |
| S | 0071895 | biological_process | odontoblast differentiation |
| S | 0072686 | cellular_component | mitotic spindle |
| S | 0097228 | cellular_component | sperm principal piece |
| S | 0097229 | cellular_component | sperm end piece |
| S | 0097542 | cellular_component | ciliary tip |
| U | 0000166 | molecular_function | nucleotide binding |
| U | 0000226 | biological_process | microtubule cytoskeleton organization |
| U | 0000278 | biological_process | mitotic cell cycle |
| U | 0003924 | molecular_function | GTPase activity |
| U | 0005198 | molecular_function | structural molecule activity |
| U | 0005200 | molecular_function | structural constituent of cytoskeleton |
| U | 0005515 | molecular_function | protein binding |
| U | 0005525 | molecular_function | GTP binding |
| U | 0005576 | cellular_component | extracellular region |
| U | 0005634 | cellular_component | nucleus |
| U | 0005641 | cellular_component | nuclear envelope lumen |
| U | 0005737 | cellular_component | cytoplasm |
| U | 0005829 | cellular_component | cytosol |
| U | 0005856 | cellular_component | cytoskeleton |
| U | 0005874 | cellular_component | microtubule |
| U | 0005929 | cellular_component | cilium |
| U | 0007017 | biological_process | microtubule-based process |
| U | 0015630 | cellular_component | microtubule cytoskeleton |
| U | 0019904 | molecular_function | protein domain specific binding |
| U | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| U | 0031625 | molecular_function | ubiquitin protein ligase binding |
| U | 0032794 | molecular_function | GTPase activating protein binding |
| U | 0032991 | cellular_component | protein-containing complex |
| U | 0035578 | cellular_component | azurophil granule lumen |
| U | 0036464 | cellular_component | cytoplasmic ribonucleoprotein granule |
| U | 0042267 | biological_process | natural killer cell mediated cytotoxicity |
| U | 0042288 | molecular_function | MHC class I protein binding |
| U | 0044297 | cellular_component | cell body |
| U | 0044877 | molecular_function | protein-containing complex binding |
| U | 0045121 | cellular_component | membrane raft |
| U | 0045171 | cellular_component | intercellular bridge |
| U | 0046872 | molecular_function | metal ion binding |
| U | 0050807 | biological_process | regulation of synapse organization |
| U | 0051301 | biological_process | cell division |
| U | 0070062 | cellular_component | extracellular exosome |
| U | 0071895 | biological_process | odontoblast differentiation |
| U | 0072686 | cellular_component | mitotic spindle |
| U | 0097228 | cellular_component | sperm principal piece |
| U | 0097229 | cellular_component | sperm end piece |
| U | 0097542 | cellular_component | ciliary tip |
| X | 0000166 | molecular_function | nucleotide binding |
| X | 0000226 | biological_process | microtubule cytoskeleton organization |
| X | 0000278 | biological_process | mitotic cell cycle |
| X | 0003725 | molecular_function | double-stranded RNA binding |
| X | 0003924 | molecular_function | GTPase activity |
| X | 0005198 | molecular_function | structural molecule activity |
| X | 0005200 | molecular_function | structural constituent of cytoskeleton |
| X | 0005515 | molecular_function | protein binding |
| X | 0005525 | molecular_function | GTP binding |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0005856 | cellular_component | cytoskeleton |
| X | 0005874 | cellular_component | microtubule |
| X | 0005881 | cellular_component | cytoplasmic microtubule |
| X | 0005929 | cellular_component | cilium |
| X | 0007017 | biological_process | microtubule-based process |
| X | 0015630 | cellular_component | microtubule cytoskeleton |
| X | 0016787 | molecular_function | hydrolase activity |
| X | 0030182 | biological_process | neuron differentiation |
| X | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
| X | 0031625 | molecular_function | ubiquitin protein ligase binding |
| X | 0051301 | biological_process | cell division |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue GTP X 501 |
| Chain | Residue |
| X | GLY10 |
| X | GLY143 |
| X | GLY144 |
| X | THR145 |
| X | GLY146 |
| X | THR179 |
| X | ASN206 |
| X | TYR224 |
| X | ASN228 |
| X | MG502 |
| X | GLN11 |
| X | ALA12 |
| X | GLN15 |
| X | ASP98 |
| X | ALA99 |
| X | ALA100 |
| X | ASN101 |
| X | SER140 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MG X 502 |
| Chain | Residue |
| X | GLU71 |
| X | GTP501 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue GTP O 501 |
| Chain | Residue |
| O | GLY10 |
| O | GLN11 |
| O | ALA12 |
| O | GLN15 |
| O | ASP98 |
| O | ALA99 |
| O | ALA100 |
| O | ASN101 |
| O | SER140 |
| O | GLY143 |
| O | GLY144 |
| O | THR145 |
| O | GLY146 |
| O | THR179 |
| O | GLU183 |
| O | ASN206 |
| O | TYR224 |
| O | ASN228 |
| O | MG502 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG O 502 |
| Chain | Residue |
| O | GLU71 |
| O | GTP501 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue GDP U 501 |
| Chain | Residue |
| U | GLY10 |
| U | GLN11 |
| U | CYS12 |
| U | GLN15 |
| U | SER140 |
| U | GLY143 |
| U | GLY144 |
| U | THR145 |
| U | GLY146 |
| U | ASN206 |
| U | TYR224 |
| U | ASN228 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue TA1 U 502 |
| Chain | Residue |
| U | VAL23 |
| U | ASP26 |
| U | HIS229 |
| U | ALA233 |
| U | SER236 |
| U | THR276 |
| U | ARG278 |
| U | GLN281 |
| U | ARG369 |
| U | LEU371 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue GDP S 501 |
| Chain | Residue |
| S | GLY10 |
| S | GLN11 |
| S | CYS12 |
| S | GLN15 |
| S | SER140 |
| S | GLY143 |
| S | GLY144 |
| S | THR145 |
| S | GLY146 |
| S | ASN206 |
| S | TYR224 |
| S | ASN228 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue TA1 S 502 |
| Chain | Residue |
| S | GLU22 |
| S | VAL23 |
| S | ASP26 |
| S | HIS229 |
| S | ALA233 |
| S | SER236 |
| S | THR276 |
| S | ARG278 |
| S | GLN281 |
| S | ARG369 |
| S | LEU371 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Motif: {"description":"MREC motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34996871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35482892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38609661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7SJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | Motif: {"description":"MREI motif","evidences":[{"source":"PubMed","id":"31727855","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"16371510","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Campbell A.","Ozanne B.W.","Lourenco F.","Olson M.F."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate"} |
| Chain | Residue | Details |
