Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QUS

HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0005516	molecular_function	calmodulin binding
I	0008017	molecular_function	microtubule binding
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0003725	molecular_function	double-stranded RNA binding
O	0003924	molecular_function	GTPase activity
O	0005198	molecular_function	structural molecule activity
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005515	molecular_function	protein binding
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0005881	cellular_component	cytoplasmic microtubule
O	0007017	biological_process	microtubule-based process
O	0015630	cellular_component	microtubule cytoskeleton
O	0016787	molecular_function	hydrolase activity
O	0030705	biological_process	cytoskeleton-dependent intracellular transport
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0051301	biological_process	cell division
O	0071353	biological_process	cellular response to interleukin-4
S	0000226	biological_process	microtubule cytoskeleton organization
S	0000278	biological_process	mitotic cell cycle
S	0003924	molecular_function	GTPase activity
S	0005198	molecular_function	structural molecule activity
S	0005200	molecular_function	structural constituent of cytoskeleton
S	0005515	molecular_function	protein binding
S	0005525	molecular_function	GTP binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005641	cellular_component	nuclear envelope lumen
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005874	cellular_component	microtubule
S	0007017	biological_process	microtubule-based process
S	0015630	cellular_component	microtubule cytoskeleton
S	0019904	molecular_function	protein domain specific binding
S	0030705	biological_process	cytoskeleton-dependent intracellular transport
S	0031625	molecular_function	ubiquitin protein ligase binding
S	0032794	molecular_function	GTPase activating protein binding
S	0032991	cellular_component	protein-containing complex
S	0035578	cellular_component	azurophil granule lumen
S	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
S	0042267	biological_process	natural killer cell mediated cytotoxicity
S	0042288	molecular_function	MHC class I protein binding
S	0044297	cellular_component	cell body
S	0044877	molecular_function	protein-containing complex binding
S	0045121	cellular_component	membrane raft
S	0045171	cellular_component	intercellular bridge
S	0046872	molecular_function	metal ion binding
S	0050807	biological_process	regulation of synapse organization
S	0051225	biological_process	spindle assembly
S	0051301	biological_process	cell division
S	0070062	cellular_component	extracellular exosome
S	0071895	biological_process	odontoblast differentiation
S	0072686	cellular_component	mitotic spindle
U	0000226	biological_process	microtubule cytoskeleton organization
U	0000278	biological_process	mitotic cell cycle
U	0003924	molecular_function	GTPase activity
U	0005198	molecular_function	structural molecule activity
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005515	molecular_function	protein binding
U	0005525	molecular_function	GTP binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005641	cellular_component	nuclear envelope lumen
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005856	cellular_component	cytoskeleton
U	0005874	cellular_component	microtubule
U	0007017	biological_process	microtubule-based process
U	0015630	cellular_component	microtubule cytoskeleton
U	0019904	molecular_function	protein domain specific binding
U	0030705	biological_process	cytoskeleton-dependent intracellular transport
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0032794	molecular_function	GTPase activating protein binding
U	0032991	cellular_component	protein-containing complex
U	0035578	cellular_component	azurophil granule lumen
U	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
U	0042267	biological_process	natural killer cell mediated cytotoxicity
U	0042288	molecular_function	MHC class I protein binding
U	0044297	cellular_component	cell body
U	0044877	molecular_function	protein-containing complex binding
U	0045121	cellular_component	membrane raft
U	0045171	cellular_component	intercellular bridge
U	0046872	molecular_function	metal ion binding
U	0050807	biological_process	regulation of synapse organization
U	0051225	biological_process	spindle assembly
U	0051301	biological_process	cell division
U	0070062	cellular_component	extracellular exosome
U	0071895	biological_process	odontoblast differentiation
U	0072686	cellular_component	mitotic spindle
X	0000226	biological_process	microtubule cytoskeleton organization
X	0000278	biological_process	mitotic cell cycle
X	0003725	molecular_function	double-stranded RNA binding
X	0003924	molecular_function	GTPase activity
X	0005198	molecular_function	structural molecule activity
X	0005200	molecular_function	structural constituent of cytoskeleton
X	0005515	molecular_function	protein binding
X	0005525	molecular_function	GTP binding
X	0005737	cellular_component	cytoplasm
X	0005856	cellular_component	cytoskeleton
X	0005874	cellular_component	microtubule
X	0005881	cellular_component	cytoplasmic microtubule
X	0007017	biological_process	microtubule-based process
X	0015630	cellular_component	microtubule cytoskeleton
X	0016787	molecular_function	hydrolase activity
X	0030705	biological_process	cytoskeleton-dependent intracellular transport
X	0031625	molecular_function	ubiquitin protein ligase binding
X	0051301	biological_process	cell division
X	0071353	biological_process	cellular response to interleukin-4

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue GTP X 501

Chain	Residue
X	GLY10
X	GLY143
X	GLY144
X	THR145
X	GLY146
X	THR179
X	ASN206
X	TYR224
X	ASN228
X	MG502
X	GLN11
X	ALA12
X	GLN15
X	ASP98
X	ALA99
X	ALA100
X	ASN101
X	SER140

site_id	AC2
Number of Residues	2
Details	binding site for residue MG X 502

Chain	Residue
X	GLU71
X	GTP501

site_id	AC3
Number of Residues	19
Details	binding site for residue GTP O 501

Chain	Residue
O	GLY10
O	GLN11
O	ALA12
O	GLN15
O	ASP98
O	ALA99
O	ALA100
O	ASN101
O	SER140
O	GLY143
O	GLY144
O	THR145
O	GLY146
O	THR179
O	GLU183
O	ASN206
O	TYR224
O	ASN228
O	MG502

site_id	AC4
Number of Residues	2
Details	binding site for residue MG O 502

Chain	Residue
O	GLU71
O	GTP501

site_id	AC5
Number of Residues	12
Details	binding site for residue GDP U 501

Chain	Residue
U	GLY10
U	GLN11
U	CYS12
U	GLN15
U	SER140
U	GLY143
U	GLY144
U	THR145
U	GLY146
U	ASN206
U	TYR224
U	ASN228

site_id	AC6
Number of Residues	10
Details	binding site for residue TA1 U 502

Chain	Residue
U	VAL23
U	ASP26
U	HIS229
U	ALA233
U	SER236
U	THR276
U	ARG278
U	GLN281
U	ARG369
U	LEU371

site_id	AC7
Number of Residues	12
Details	binding site for residue GDP S 501

Chain	Residue
S	GLY10
S	GLN11
S	CYS12
S	GLN15
S	SER140
S	GLY143
S	GLY144
S	THR145
S	GLY146
S	ASN206
S	TYR224
S	ASN228

site_id	AC8
Number of Residues	11
Details	binding site for residue TA1 S 502

Chain	Residue
S	GLU22
S	VAL23
S	ASP26
S	HIS229
S	ALA233
S	SER236
S	THR276
S	ARG278
S	GLN281
S	ARG369
S	LEU371

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
X	GLY142-GLY148
U	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
U	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q13509

Chain	Residue	Details
U	GLN11
S	GLY144
S	THR145
S	GLY146
S	ASN206
S	ASN228
U	SER140
U	GLY144
U	THR145
U	GLY146
U	ASN206
U	ASN228
S	GLN11
S	SER140

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
U	GLU71
O	GLU71
O	SER140
O	GLY144
O	THR145
O	THR179
O	ASN206
O	ASN228
S	GLU71
X	SER140
X	GLY144
X	THR145
X	THR179
X	ASN206
X	ASN228
O	GLN11

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
U	SER40
S	SER40

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
U	THR57
U	THR287
U	THR292
S	THR57
S	THR287
S	THR292

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
U	LYS60
S	LYS60
O	SER48
O	SER232

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269\|PubMed:16371510

Chain	Residue	Details
U	SER174
S	SER174

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269\|Ref.9

Chain	Residue	Details
U	ARG320
S	ARG320

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:28576883

Chain	Residue	Details
U	GLU444
U	GLU451
S	GLU444
S	GLU451

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000269\|PubMed:32747782

Chain	Residue	Details
U	GLU448
U	GLU449
S	GLU448
S	GLU449

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: 5-glutamyl glycine => ECO:0000269\|PubMed:28576883

Chain	Residue	Details
U	GLU452
U	GLU453
S	GLU452
S	GLU453

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
U	LYS60
S	LYS60

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
X	LYS326
U	LYS326
X	LYS370
S	LYS326
O	LYS370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)