6QTI
Structure of ovine transhydrogenase in the presence of NADP+ in a "double face-down" conformation
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue NAP A 1101 |
| Chain | Residue |
| A | ALA786 |
| A | GLY964 |
| A | ASN966 |
| A | ASP967 |
| A | THR968 |
| A | LYS999 |
| A | ARG1000 |
| A | SER1001 |
| A | ASP1025 |
| A | ALA1026 |
| A | PRO789 |
| A | MET833 |
| A | MET837 |
| A | ALA895 |
| A | VAL922 |
| A | ALA923 |
| A | GLY924 |
| A | ARG925 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue NAD A 1102 |
| Chain | Residue |
| A | ARG139 |
| A | GLY191 |
| A | GLY192 |
| A | GLY193 |
| A | VAL194 |
| A | ASP214 |
| A | THR215 |
| A | ARG216 |
| A | GLY244 |
| A | TYR245 |
| A | ALA246 |
| A | GLU257 |
| A | THR274 |
| A | ALA275 |
| A | LEU276 |
| A | ILE277 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PC1 A 1103 |
| Chain | Residue |
| A | TYR470 |
| A | TRP474 |
| A | TYR831 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PC1 A 1104 |
| Chain | Residue |
| A | PHE462 |
| A | GLY463 |
| A | TYR470 |
| A | HIS471 |
| B | LEU586 |
| B | VAL589 |
| B | GLY590 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue PC1 A 1105 |
| Chain | Residue |
| A | TYR798 |
| A | TRP801 |
| A | SER830 |
| A | TYR831 |
| A | ARG839 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PC1 A 1107 |
| Chain | Residue |
| A | GLN536 |
| A | ASP540 |
| A | ASN552 |
| A | GLY560 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue PC1 A 1108 |
| Chain | Residue |
| A | LEU567 |
| A | LEU570 |
| A | TYR571 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PC1 A 1109 |
| Chain | Residue |
| A | LEU586 |
| A | ALA593 |
| B | TYR470 |
| B | HIS471 |
| B | PC11104 |
| B | PC11106 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PC1 B 1101 |
| Chain | Residue |
| A | GLY445 |
| A | ALA449 |
| B | SER572 |
| B | TYR574 |
| site_id | AD1 |
| Number of Residues | 20 |
| Details | binding site for residue NAP B 1102 |
| Chain | Residue |
| B | ALA786 |
| B | ASP787 |
| B | PRO789 |
| B | MET833 |
| B | MET837 |
| B | GLY891 |
| B | ALA895 |
| B | VAL922 |
| B | GLY924 |
| B | ARG925 |
| B | GLY964 |
| B | ASN966 |
| B | ASP967 |
| B | THR968 |
| B | LYS999 |
| B | ARG1000 |
| B | SER1001 |
| B | VAL1004 |
| B | GLY1005 |
| B | ALA1026 |
| site_id | AD2 |
| Number of Residues | 15 |
| Details | binding site for residue NAD B 1103 |
| Chain | Residue |
| B | LEU276 |
| B | ILE277 |
| B | ARG139 |
| B | GLN144 |
| B | GLY192 |
| B | GLY193 |
| B | VAL194 |
| B | ASP214 |
| B | THR215 |
| B | ARG216 |
| B | GLY244 |
| B | ALA246 |
| B | GLU257 |
| B | THR274 |
| B | ALA275 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue PC1 B 1104 |
| Chain | Residue |
| A | PC11109 |
| B | PHE462 |
| B | GLY466 |
| B | TYR470 |
| B | TRP474 |
| B | SER824 |
| B | ILE828 |
| B | TYR831 |
| B | PC11105 |
| B | PC11106 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue PC1 B 1105 |
| Chain | Residue |
| B | SER797 |
| B | TYR798 |
| B | TRP801 |
| B | SER830 |
| B | TYR831 |
| B | PC11104 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue PC1 B 1106 |
| Chain | Residue |
| A | PC11109 |
| B | VAL435 |
| B | TYR436 |
| B | GLY439 |
| B | PC11104 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue D12 B 1107 |
| Chain | Residue |
| B | ALA449 |
| B | PHE808 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue D12 B 1108 |
| Chain | Residue |
| B | GLY445 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue PC1 B 1109 |
| Chain | Residue |
| B | GLN536 |
| B | ASP540 |
| B | ASN552 |
| B | TYR555 |
| B | VAL563 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue PC1 B 1110 |
| Chain | Residue |
| B | LEU570 |
| B | TYR571 |
| B | LEU620 |
| B | LYS624 |
Functional Information from PROSITE/UniProt
| site_id | PS00836 |
| Number of Residues | 27 |
| Details | ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. GVPkEifqNEk..RVAlSPaGVqaLvKqG |
| Chain | Residue | Details |
| A | GLY17-GLY43 |
| site_id | PS00837 |
| Number of Residues | 26 |
| Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. IVGGGvAGlaSagaAkSMGAiVrgfD |
| Chain | Residue | Details |
| A | ILE189-ASP214 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 550 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"UniProtKB","id":"P11024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P11024","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31462775","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6QTI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QUE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31462775","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6QUE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P07001","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13423","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13423","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q61941","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
