Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QSU

Helicobacter pylori urease with BME bound in the active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0009039	molecular_function	urease activity
A	0016151	molecular_function	nickel cation binding
A	0016787	molecular_function	hydrolase activity
A	0019627	biological_process	urea metabolic process
A	0035550	cellular_component	urease complex
A	0043419	biological_process	urea catabolic process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006807	biological_process	obsolete nitrogen compound metabolic process
B	0009039	molecular_function	urease activity
B	0016151	molecular_function	nickel cation binding
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0019627	biological_process	urea metabolic process
B	0043419	biological_process	urea catabolic process
B	0046872	molecular_function	metal ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0009039	molecular_function	urease activity
C	0016151	molecular_function	nickel cation binding
C	0016787	molecular_function	hydrolase activity
C	0019627	biological_process	urea metabolic process
C	0035550	cellular_component	urease complex
C	0043419	biological_process	urea catabolic process
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006807	biological_process	obsolete nitrogen compound metabolic process
D	0009039	molecular_function	urease activity
D	0016151	molecular_function	nickel cation binding
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0019627	biological_process	urea metabolic process
D	0043419	biological_process	urea catabolic process
D	0046872	molecular_function	metal ion binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0009039	molecular_function	urease activity
E	0016151	molecular_function	nickel cation binding
E	0016787	molecular_function	hydrolase activity
E	0019627	biological_process	urea metabolic process
E	0035550	cellular_component	urease complex
E	0043419	biological_process	urea catabolic process
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006807	biological_process	obsolete nitrogen compound metabolic process
F	0009039	molecular_function	urease activity
F	0016151	molecular_function	nickel cation binding
F	0016787	molecular_function	hydrolase activity
F	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
F	0019627	biological_process	urea metabolic process
F	0043419	biological_process	urea catabolic process
F	0046872	molecular_function	metal ion binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0009039	molecular_function	urease activity
G	0016151	molecular_function	nickel cation binding
G	0016787	molecular_function	hydrolase activity
G	0019627	biological_process	urea metabolic process
G	0035550	cellular_component	urease complex
G	0043419	biological_process	urea catabolic process
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006807	biological_process	obsolete nitrogen compound metabolic process
H	0009039	molecular_function	urease activity
H	0016151	molecular_function	nickel cation binding
H	0016787	molecular_function	hydrolase activity
H	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
H	0019627	biological_process	urea metabolic process
H	0043419	biological_process	urea catabolic process
H	0046872	molecular_function	metal ion binding
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0009039	molecular_function	urease activity
I	0016151	molecular_function	nickel cation binding
I	0016787	molecular_function	hydrolase activity
I	0019627	biological_process	urea metabolic process
I	0035550	cellular_component	urease complex
I	0043419	biological_process	urea catabolic process
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0006807	biological_process	obsolete nitrogen compound metabolic process
J	0009039	molecular_function	urease activity
J	0016151	molecular_function	nickel cation binding
J	0016787	molecular_function	hydrolase activity
J	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
J	0019627	biological_process	urea metabolic process
J	0043419	biological_process	urea catabolic process
J	0046872	molecular_function	metal ion binding
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0009039	molecular_function	urease activity
K	0016151	molecular_function	nickel cation binding
K	0016787	molecular_function	hydrolase activity
K	0019627	biological_process	urea metabolic process
K	0035550	cellular_component	urease complex
K	0043419	biological_process	urea catabolic process
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006807	biological_process	obsolete nitrogen compound metabolic process
L	0009039	molecular_function	urease activity
L	0016151	molecular_function	nickel cation binding
L	0016787	molecular_function	hydrolase activity
L	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
L	0019627	biological_process	urea metabolic process
L	0043419	biological_process	urea catabolic process
L	0046872	molecular_function	metal ion binding
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0009039	molecular_function	urease activity
M	0016151	molecular_function	nickel cation binding
M	0016787	molecular_function	hydrolase activity
M	0019627	biological_process	urea metabolic process
M	0035550	cellular_component	urease complex
M	0043419	biological_process	urea catabolic process
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0006807	biological_process	obsolete nitrogen compound metabolic process
N	0009039	molecular_function	urease activity
N	0016151	molecular_function	nickel cation binding
N	0016787	molecular_function	hydrolase activity
N	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
N	0019627	biological_process	urea metabolic process
N	0043419	biological_process	urea catabolic process
N	0046872	molecular_function	metal ion binding
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0009039	molecular_function	urease activity
O	0016151	molecular_function	nickel cation binding
O	0016787	molecular_function	hydrolase activity
O	0019627	biological_process	urea metabolic process
O	0035550	cellular_component	urease complex
O	0043419	biological_process	urea catabolic process
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0006807	biological_process	obsolete nitrogen compound metabolic process
P	0009039	molecular_function	urease activity
P	0016151	molecular_function	nickel cation binding
P	0016787	molecular_function	hydrolase activity
P	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
P	0019627	biological_process	urea metabolic process
P	0043419	biological_process	urea catabolic process
P	0046872	molecular_function	metal ion binding
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0009039	molecular_function	urease activity
Q	0016151	molecular_function	nickel cation binding
Q	0016787	molecular_function	hydrolase activity
Q	0019627	biological_process	urea metabolic process
Q	0035550	cellular_component	urease complex
Q	0043419	biological_process	urea catabolic process
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0006807	biological_process	obsolete nitrogen compound metabolic process
R	0009039	molecular_function	urease activity
R	0016151	molecular_function	nickel cation binding
R	0016787	molecular_function	hydrolase activity
R	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
R	0019627	biological_process	urea metabolic process
R	0043419	biological_process	urea catabolic process
R	0046872	molecular_function	metal ion binding
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0009039	molecular_function	urease activity
S	0016151	molecular_function	nickel cation binding
S	0016787	molecular_function	hydrolase activity
S	0019627	biological_process	urea metabolic process
S	0035550	cellular_component	urease complex
S	0043419	biological_process	urea catabolic process
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0006807	biological_process	obsolete nitrogen compound metabolic process
T	0009039	molecular_function	urease activity
T	0016151	molecular_function	nickel cation binding
T	0016787	molecular_function	hydrolase activity
T	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
T	0019627	biological_process	urea metabolic process
T	0043419	biological_process	urea catabolic process
T	0046872	molecular_function	metal ion binding
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0009039	molecular_function	urease activity
U	0016151	molecular_function	nickel cation binding
U	0016787	molecular_function	hydrolase activity
U	0019627	biological_process	urea metabolic process
U	0035550	cellular_component	urease complex
U	0043419	biological_process	urea catabolic process
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0006807	biological_process	obsolete nitrogen compound metabolic process
V	0009039	molecular_function	urease activity
V	0016151	molecular_function	nickel cation binding
V	0016787	molecular_function	hydrolase activity
V	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
V	0019627	biological_process	urea metabolic process
V	0043419	biological_process	urea catabolic process
V	0046872	molecular_function	metal ion binding
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0009039	molecular_function	urease activity
W	0016151	molecular_function	nickel cation binding
W	0016787	molecular_function	hydrolase activity
W	0019627	biological_process	urea metabolic process
W	0035550	cellular_component	urease complex
W	0043419	biological_process	urea catabolic process
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0006807	biological_process	obsolete nitrogen compound metabolic process
X	0009039	molecular_function	urease activity
X	0016151	molecular_function	nickel cation binding
X	0016787	molecular_function	hydrolase activity
X	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
X	0019627	biological_process	urea metabolic process
X	0043419	biological_process	urea catabolic process
X	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00145
Number of Residues	17
Details	UREASE_2 Urease active site. MVCHHLdksIkeDVqFA

Chain	Residue	Details
B	MET319-ALA335

site_id	PS01120
Number of Residues	14
Details	UREASE_1 Urease nickel ligands signature. TAGGIDtHIHfisP

Chain	Residue	Details
B	THR129-PRO142

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton donor => ECO:0000305

Chain	Residue	Details
B	HIS322
T	HIS322
V	HIS322
X	HIS322
J	HIS322
D	HIS322
F	HIS322
H	HIS322
L	HIS322
N	HIS322
P	HIS322
R	HIS322

site_id	SWS_FT_FI2
Number of Residues	60
Details	BINDING:

Chain	Residue	Details
B	HIS136
J	ASP362
D	HIS136
D	HIS138
D	HIS248
D	HIS274
D	ASP362
F	HIS136
F	HIS138
F	HIS248
F	HIS274
B	HIS138
F	ASP362
H	HIS136
H	HIS138
H	HIS248
H	HIS274
H	ASP362
L	HIS136
L	HIS138
L	HIS248
L	HIS274
B	HIS248
L	ASP362
N	HIS136
N	HIS138
N	HIS248
N	HIS274
N	ASP362
P	HIS136
P	HIS138
P	HIS248
P	HIS274
B	HIS274
P	ASP362
R	HIS136
R	HIS138
R	HIS248
R	HIS274
R	ASP362
T	HIS136
T	HIS138
T	HIS248
T	HIS274
B	ASP362
T	ASP362
V	HIS136
V	HIS138
V	HIS248
V	HIS274
V	ASP362
X	HIS136
X	HIS138
X	HIS248
X	HIS274
J	HIS136
X	ASP362
J	HIS138
J	HIS248
J	HIS274

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: via carbamate group

Chain	Residue	Details
B	KCX219
T	KCX219
V	KCX219
X	KCX219
J	KCX219
D	KCX219
F	KCX219
H	KCX219
L	KCX219
N	KCX219
P	KCX219
R	KCX219

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
B	HIS221
T	HIS221
V	HIS221
X	HIS221
J	HIS221
D	HIS221
F	HIS221
H	HIS221
L	HIS221
N	HIS221
P	HIS221
R	HIS221

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N6-carboxylysine => ECO:0000255\|HAMAP-Rule:MF_01953, ECO:0000269\|PubMed:11373617

Chain	Residue	Details
B	KCX219
T	KCX219
V	KCX219
X	KCX219
J	KCX219
D	KCX219
F	KCX219
H	KCX219
L	KCX219
N	KCX219
P	KCX219
R	KCX219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)