6QSU

Helicobacter pylori urease with BME bound in the active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0009039	molecular_function	urease activity
A	0016151	molecular_function	nickel cation binding
A	0016787	molecular_function	hydrolase activity
A	0035550	cellular_component	urease complex
A	0043419	biological_process	urea catabolic process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0009039	molecular_function	urease activity
B	0016151	molecular_function	nickel cation binding
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0043419	biological_process	urea catabolic process
B	0046872	molecular_function	metal ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0009039	molecular_function	urease activity
C	0016151	molecular_function	nickel cation binding
C	0016787	molecular_function	hydrolase activity
C	0035550	cellular_component	urease complex
C	0043419	biological_process	urea catabolic process
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0009039	molecular_function	urease activity
D	0016151	molecular_function	nickel cation binding
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0043419	biological_process	urea catabolic process
D	0046872	molecular_function	metal ion binding
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0009039	molecular_function	urease activity
E	0016151	molecular_function	nickel cation binding
E	0016787	molecular_function	hydrolase activity
E	0035550	cellular_component	urease complex
E	0043419	biological_process	urea catabolic process
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0009039	molecular_function	urease activity
F	0016151	molecular_function	nickel cation binding
F	0016787	molecular_function	hydrolase activity
F	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
F	0043419	biological_process	urea catabolic process
F	0046872	molecular_function	metal ion binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0009039	molecular_function	urease activity
G	0016151	molecular_function	nickel cation binding
G	0016787	molecular_function	hydrolase activity
G	0035550	cellular_component	urease complex
G	0043419	biological_process	urea catabolic process
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0009039	molecular_function	urease activity
H	0016151	molecular_function	nickel cation binding
H	0016787	molecular_function	hydrolase activity
H	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
H	0043419	biological_process	urea catabolic process
H	0046872	molecular_function	metal ion binding
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0009039	molecular_function	urease activity
I	0016151	molecular_function	nickel cation binding
I	0016787	molecular_function	hydrolase activity
I	0035550	cellular_component	urease complex
I	0043419	biological_process	urea catabolic process
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0009039	molecular_function	urease activity
J	0016151	molecular_function	nickel cation binding
J	0016787	molecular_function	hydrolase activity
J	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
J	0043419	biological_process	urea catabolic process
J	0046872	molecular_function	metal ion binding
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0009039	molecular_function	urease activity
K	0016151	molecular_function	nickel cation binding
K	0016787	molecular_function	hydrolase activity
K	0035550	cellular_component	urease complex
K	0043419	biological_process	urea catabolic process
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0009039	molecular_function	urease activity
L	0016151	molecular_function	nickel cation binding
L	0016787	molecular_function	hydrolase activity
L	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
L	0043419	biological_process	urea catabolic process
L	0046872	molecular_function	metal ion binding
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0009039	molecular_function	urease activity
M	0016151	molecular_function	nickel cation binding
M	0016787	molecular_function	hydrolase activity
M	0035550	cellular_component	urease complex
M	0043419	biological_process	urea catabolic process
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0009039	molecular_function	urease activity
N	0016151	molecular_function	nickel cation binding
N	0016787	molecular_function	hydrolase activity
N	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
N	0043419	biological_process	urea catabolic process
N	0046872	molecular_function	metal ion binding
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0009039	molecular_function	urease activity
O	0016151	molecular_function	nickel cation binding
O	0016787	molecular_function	hydrolase activity
O	0035550	cellular_component	urease complex
O	0043419	biological_process	urea catabolic process
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0009039	molecular_function	urease activity
P	0016151	molecular_function	nickel cation binding
P	0016787	molecular_function	hydrolase activity
P	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
P	0043419	biological_process	urea catabolic process
P	0046872	molecular_function	metal ion binding
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0009039	molecular_function	urease activity
Q	0016151	molecular_function	nickel cation binding
Q	0016787	molecular_function	hydrolase activity
Q	0035550	cellular_component	urease complex
Q	0043419	biological_process	urea catabolic process
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0009039	molecular_function	urease activity
R	0016151	molecular_function	nickel cation binding
R	0016787	molecular_function	hydrolase activity
R	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
R	0043419	biological_process	urea catabolic process
R	0046872	molecular_function	metal ion binding
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0009039	molecular_function	urease activity
S	0016151	molecular_function	nickel cation binding
S	0016787	molecular_function	hydrolase activity
S	0035550	cellular_component	urease complex
S	0043419	biological_process	urea catabolic process
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0009039	molecular_function	urease activity
T	0016151	molecular_function	nickel cation binding
T	0016787	molecular_function	hydrolase activity
T	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
T	0043419	biological_process	urea catabolic process
T	0046872	molecular_function	metal ion binding
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0009039	molecular_function	urease activity
U	0016151	molecular_function	nickel cation binding
U	0016787	molecular_function	hydrolase activity
U	0035550	cellular_component	urease complex
U	0043419	biological_process	urea catabolic process
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0009039	molecular_function	urease activity
V	0016151	molecular_function	nickel cation binding
V	0016787	molecular_function	hydrolase activity
V	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
V	0043419	biological_process	urea catabolic process
V	0046872	molecular_function	metal ion binding
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0009039	molecular_function	urease activity
W	0016151	molecular_function	nickel cation binding
W	0016787	molecular_function	hydrolase activity
W	0035550	cellular_component	urease complex
W	0043419	biological_process	urea catabolic process
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0009039	molecular_function	urease activity
X	0016151	molecular_function	nickel cation binding
X	0016787	molecular_function	hydrolase activity
X	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
X	0043419	biological_process	urea catabolic process
X	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00145
Number of Residues	17
Details	UREASE_2 Urease active site. MVCHHLdksIkeDVqFA

Chain	Residue	Details
B	MET319-ALA335

---

site_id	PS01120
Number of Residues	14
Details	UREASE_1 Urease nickel ligands signature. TAGGIDtHIHfisP

Chain	Residue	Details
B	THR129-PRO142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1212
Details	Region: {"description":"Urease gamma"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1620
Details	Region: {"description":"Urease beta"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"description":"via carbamate group"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01953","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11373617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---