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6QPI

Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0002407biological_processdendritic cell chemotaxis
A0005227molecular_functioncalcium-activated cation channel activity
A0005229molecular_functionintracellularly calcium-gated chloride channel activity
A0005244molecular_functionvoltage-gated monoatomic ion channel activity
A0005254molecular_functionchloride channel activity
A0005886cellular_componentplasma membrane
A0006821biological_processchloride transport
A0006869biological_processlipid transport
A0007596biological_processblood coagulation
A0017121biological_processplasma membrane phospholipid scrambling
A0017128molecular_functionphospholipid scramblase activity
A0030501biological_processpositive regulation of bone mineralization
A0032060biological_processbleb assembly
A0034220biological_processmonoatomic ion transmembrane transport
A0034707cellular_componentchloride channel complex
A0034767biological_processpositive regulation of monoatomic ion transmembrane transport
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0035630biological_processbone mineralization involved in bone maturation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043065biological_processpositive regulation of apoptotic process
A0045332biological_processphospholipid translocation
A0045794biological_processnegative regulation of cell volume
A0046872molecular_functionmetal ion binding
A0046983molecular_functionprotein dimerization activity
A0051649biological_processestablishment of localization in cell
A0060078biological_processregulation of postsynaptic membrane potential
A0060100biological_processpositive regulation of phagocytosis, engulfment
A0061588biological_processcalcium activated phospholipid scrambling
A0061589biological_processcalcium activated phosphatidylserine scrambling
A0061590biological_processcalcium activated phosphatidylcholine scrambling
A0061591biological_processcalcium activated galactosylceramide scrambling
A0070588biological_processcalcium ion transmembrane transport
A0090026biological_processpositive regulation of monocyte chemotaxis
A0097060cellular_componentsynaptic membrane
A0098981cellular_componentcholinergic synapse
A1902476biological_processchloride transmembrane transport
A1903766biological_processpositive regulation of potassium ion export across plasma membrane
B0002407biological_processdendritic cell chemotaxis
B0005227molecular_functioncalcium-activated cation channel activity
B0005229molecular_functionintracellularly calcium-gated chloride channel activity
B0005244molecular_functionvoltage-gated monoatomic ion channel activity
B0005254molecular_functionchloride channel activity
B0005886cellular_componentplasma membrane
B0006821biological_processchloride transport
B0006869biological_processlipid transport
B0007596biological_processblood coagulation
B0017121biological_processplasma membrane phospholipid scrambling
B0017128molecular_functionphospholipid scramblase activity
B0030501biological_processpositive regulation of bone mineralization
B0032060biological_processbleb assembly
B0034220biological_processmonoatomic ion transmembrane transport
B0034707cellular_componentchloride channel complex
B0034767biological_processpositive regulation of monoatomic ion transmembrane transport
B0035590biological_processpurinergic nucleotide receptor signaling pathway
B0035630biological_processbone mineralization involved in bone maturation
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043065biological_processpositive regulation of apoptotic process
B0045332biological_processphospholipid translocation
B0045794biological_processnegative regulation of cell volume
B0046872molecular_functionmetal ion binding
B0046983molecular_functionprotein dimerization activity
B0051649biological_processestablishment of localization in cell
B0060078biological_processregulation of postsynaptic membrane potential
B0060100biological_processpositive regulation of phagocytosis, engulfment
B0061588biological_processcalcium activated phospholipid scrambling
B0061589biological_processcalcium activated phosphatidylserine scrambling
B0061590biological_processcalcium activated phosphatidylcholine scrambling
B0061591biological_processcalcium activated galactosylceramide scrambling
B0070588biological_processcalcium ion transmembrane transport
B0090026biological_processpositive regulation of monocyte chemotaxis
B0097060cellular_componentsynaptic membrane
B0098981cellular_componentcholinergic synapse
B1902476biological_processchloride transmembrane transport
B1903766biological_processpositive regulation of potassium ion export across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues974
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30785399
ChainResidueDetails
AMET1-ALA301
BGLN623-LEU664
BLEU707-GLY723
BASP859-GLU911
ALYS398-CYS456
AALA532-THR552
AGLN623-LEU664
ALEU707-GLY723
AASP859-GLU911
BMET1-ALA301
BLYS398-CYS456
BALA532-THR552

site_idSWS_FT_FI2
Number of Residues398
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30785399
ChainResidueDetails
ATRP302-LEU322
APHE838-PRO858
BTRP302-LEU322
BPHE377-TRP397
BALA457-TYR477
BILE511-VAL531
BMET553-PHE573
BLEU603-ILE622
BPHE665-PHE685
BPRO686-LYS706
BALA724-ILE744
APHE377-TRP397
BPHE838-PRO858
AALA457-TYR477
AILE511-VAL531
AMET553-PHE573
ALEU603-ILE622
APHE665-PHE685
APRO686-LYS706
AALA724-ILE744

site_idSWS_FT_FI3
Number of Residues410
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:30785399
ChainResidueDetails
ATYR323-SER376
AARG478-SER510
ALYS574-LEU602
AALA745-ALA837
BTYR323-SER376
BARG478-SER510
BLYS574-LEU602
BALA745-ALA837

site_idSWS_FT_FI4
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:30785399
ChainResidueDetails
AGLU624
AGLU667
AGLU670
BGLU624
BGLU667
BGLU670

site_idSWS_FT_FI5
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN330
AASN362
AASN778
BASN330
BASN362
BASN778

site_idSWS_FT_FI6
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19656770
ChainResidueDetails
AASN494
AASN785
AASN803
BASN494
BASN785
BASN803

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PDB entries from 2024-11-20

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