6QP3
Crystal structure of the PLP-bound C-S lyase from Bacillus subtilis (strain 168)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009086 | biological_process | obsolete methionine biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0047804 | molecular_function | cysteine-S-conjugate beta-lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009086 | biological_process | obsolete methionine biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0047804 | molecular_function | cysteine-S-conjugate beta-lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009086 | biological_process | obsolete methionine biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0047804 | molecular_function | cysteine-S-conjugate beta-lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009086 | biological_process | obsolete methionine biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0047804 | molecular_function | cysteine-S-conjugate beta-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 801 |
| Chain | Residue |
| A | VAL34 |
| A | ALA35 |
| A | TYR119 |
| A | ASN171 |
| A | ARG365 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue PLP A 802 |
| Chain | Residue |
| A | CYS167 |
| A | ASN171 |
| A | ASP199 |
| A | ILE201 |
| A | HIS202 |
| A | LYS234 |
| D | TYR60 |
| A | GLY93 |
| A | VAL94 |
| A | VAL95 |
| A | TYR119 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 801 |
| Chain | Residue |
| B | VAL34 |
| B | ALA35 |
| B | TYR119 |
| B | ASN171 |
| B | GLU351 |
| B | ARG365 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 801 |
| Chain | Residue |
| C | ALA35 |
| C | TYR119 |
| C | ASN171 |
| C | GLU351 |
| C | ARG365 |
| C | PLP802 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT D 801 |
| Chain | Residue |
| D | VAL34 |
| D | ALA35 |
| D | TYR119 |
| D | ASN171 |
| D | ARG365 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide PLP B 802 and LYS B 234 |
| Chain | Residue |
| B | ALA35 |
| B | MET37 |
| B | GLY93 |
| B | VAL94 |
| B | VAL95 |
| B | TYR119 |
| B | CYS167 |
| B | ASN171 |
| B | ASP199 |
| B | ILE201 |
| B | HIS202 |
| B | PRO232 |
| B | SER233 |
| B | THR235 |
| B | PHE236 |
| B | ASN237 |
| B | HOH903 |
| C | TYR60 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide PLP C 802 and LYS C 234 |
| Chain | Residue |
| B | TYR60 |
| C | ALA35 |
| C | MET37 |
| C | GLY93 |
| C | VAL94 |
| C | VAL95 |
| C | TYR119 |
| C | CYS167 |
| C | ASN171 |
| C | ASP199 |
| C | ILE201 |
| C | HIS202 |
| C | PRO232 |
| C | SER233 |
| C | THR235 |
| C | PHE236 |
| C | ACT801 |
| C | HOH904 |
| C | HOH905 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide PLP D 802 and LYS D 234 |
| Chain | Residue |
| A | TYR60 |
| D | ALA35 |
| D | MET37 |
| D | GLY93 |
| D | VAL94 |
| D | VAL95 |
| D | TYR119 |
| D | CYS167 |
| D | ASN171 |
| D | ASP199 |
| D | ILE201 |
| D | HIS202 |
| D | PRO232 |
| D | SER233 |
| D | THR235 |
| D | PHE236 |
| D | ASN237 |
| D | HOH901 |
| D | HOH903 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
