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6QNX

Structure of the SA2/SCC1/CTCF complex

Replaces:  6QNY
Functional Information from GO Data
ChainGOidnamespacecontents
A0000775cellular_componentchromosome, centromeric region
A0000785cellular_componentchromatin
A0001650cellular_componentfibrillar center
A0003682molecular_functionchromatin binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0007059biological_processchromosome segregation
A0007062biological_processsister chromatid cohesion
A0008278cellular_componentcohesin complex
A0016020cellular_componentmembrane
A0016363cellular_componentnuclear matrix
A0030892cellular_componentmitotic cohesin complex
A0034087biological_processestablishment of mitotic sister chromatid cohesion
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0090307biological_processmitotic spindle assembly
A0097431cellular_componentmitotic spindle pole
B0000775cellular_componentchromosome, centromeric region
B0000785cellular_componentchromatin
B0000794cellular_componentcondensed nuclear chromosome
B0000922cellular_componentspindle pole
B0001666biological_processresponse to hypoxia
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006310biological_processDNA recombination
B0006357biological_processregulation of transcription by RNA polymerase II
B0006915biological_processapoptotic process
B0007059biological_processchromosome segregation
B0007062biological_processsister chromatid cohesion
B0007131biological_processreciprocal meiotic recombination
B0008278cellular_componentcohesin complex
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010972biological_processnegative regulation of G2/M transition of mitotic cell cycle
B0016020cellular_componentmembrane
B0016363cellular_componentnuclear matrix
B0030496cellular_componentmidbody
B0030892cellular_componentmitotic cohesin complex
B0030893cellular_componentmeiotic cohesin complex
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032733biological_processpositive regulation of interleukin-10 production
B0034087biological_processestablishment of mitotic sister chromatid cohesion
B0034089biological_processestablishment of meiotic sister chromatid cohesion
B0034351biological_processnegative regulation of glial cell apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0045841biological_processnegative regulation of mitotic metaphase/anaphase transition
B0045876biological_processpositive regulation of sister chromatid cohesion
B0051301biological_processcell division
B0071168biological_processprotein localization to chromatin
B0106222molecular_functionlncRNA binding
B0140297molecular_functionDNA-binding transcription factor binding
B0140588biological_processchromatin looping
B1990414biological_processreplication-born double-strand break repair via sister chromatid exchange
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000775cellular_componentchromosome, centromeric region
C0000793cellular_componentcondensed chromosome
C0000976molecular_functiontranscription cis-regulatory region binding
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0001221molecular_functiontranscription coregulator binding
C0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
C0001673cellular_componentmale germ cell nucleus
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003700molecular_functionDNA-binding transcription factor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0006306biological_processobsolete DNA methylation
C0006325biological_processchromatin organization
C0006355biological_processregulation of DNA-templated transcription
C0007059biological_processchromosome segregation
C0008270molecular_functionzinc ion binding
C0008285biological_processnegative regulation of cell population proliferation
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0040029biological_processepigenetic regulation of gene expression
C0043035molecular_functionchromatin insulator sequence binding
C0043565molecular_functionsequence-specific DNA binding
C0044027biological_processnegative regulation of gene expression via chromosomal CpG island methylation
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046872molecular_functionmetal ion binding
C0070602biological_processregulation of centromeric sister chromatid cohesion
C0071459biological_processprotein localization to chromosome, centromeric region
C0071514biological_processgenomic imprinting
C0140587molecular_functionchromatin loop anchoring activity
C0140588biological_processchromatin looping
C1990837molecular_functionsequence-specific double-stranded DNA binding
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cel..CsytCprrsnldrHmks..H
ChainResidueDetails
CCYS268-HIS288
CCYS296-HIS316
CCYS324-HIS345
CCYS409-HIS430
CCYS439-HIS460
CCYS469-HIS489
CCYS497-HIS517
CCYS525-HIS546

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE266-HIS288
BARG450

site_idSWS_FT_FI2
Number of Residues22
DetailsZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CHIS294-HIS316

site_idSWS_FT_FI3
Number of Residues23
DetailsZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CHIS322-HIS345

site_idSWS_FT_FI4
Number of Residues22
DetailsZN_FING: C2H2-type 4 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE351-HIS373

site_idSWS_FT_FI5
Number of Residues22
DetailsZN_FING: C2H2-type 5 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE379-HIS401
ASER1065

site_idSWS_FT_FI6
Number of Residues23
DetailsZN_FING: C2H2-type 6 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CTYR407-HIS430

site_idSWS_FT_FI7
Number of Residues23
DetailsZN_FING: C2H2-type 7 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE437-HIS460
BTHR623

site_idSWS_FT_FI8
Number of Residues22
DetailsZN_FING: C2H2-type 8 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CLYS467-HIS489
BSER545

site_idSWS_FT_FI9
Number of Residues22
DetailsZN_FING: C2H2-type 9 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE495-HIS517
BLYS216
BLYS418

site_idSWS_FT_FI10
Number of Residues23
DetailsZN_FING: C2H2-type 10 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CTYR523-HIS546

site_idSWS_FT_FI11
Number of Residues22
DetailsZN_FING: C2H2-type 11; atypical => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE555-CYS577

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
CMET1

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
CTHR289
CTHR317

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CTHR374

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CSER402

site_idSWS_FT_FI16
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
CSER609
CSER610
CSER612

site_idSWS_FT_FI17
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS18
CLYS219

site_idSWS_FT_FI18
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS689

site_idSWS_FT_FI19
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250
ChainResidueDetails
CLYS74

223532

PDB entries from 2024-08-07

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