6QKY
Tryptophan synthase subunit alpha from Streptococcus pneumoniae with 3D domain swap in the core of TIM barrel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| E | 0000162 | biological_process | L-tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| F | 0000162 | biological_process | L-tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| G | 0000162 | biological_process | L-tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| H | 0000162 | biological_process | L-tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005829 | cellular_component | cytosol |
| H | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| I | 0000162 | biological_process | L-tryptophan biosynthetic process |
| I | 0004834 | molecular_function | tryptophan synthase activity |
| I | 0005829 | cellular_component | cytosol |
| I | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
| J | 0000162 | biological_process | L-tryptophan biosynthetic process |
| J | 0004834 | molecular_function | tryptophan synthase activity |
| J | 0005829 | cellular_component | cytosol |
| J | 0006568 | biological_process | obsolete L-tryptophan metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | LYS8 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ACY A 302 |
| Chain | Residue |
| A | ASP63 |
| A | MSE100 |
| A | TYR175 |
| B | GLU52 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 301 |
| Chain | Residue |
| B | GLU38 |
| B | THR39 |
| B | HOH410 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue ACY B 302 |
| Chain | Residue |
| B | ASP63 |
| B | ILE67 |
| B | MSE100 |
| B | TYR175 |
| B | GLY233 |
| C | LYS185 |
| A | GLU52 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 301 |
| Chain | Residue |
| C | GLU86 |
| C | LYS89 |
| C | ASP117 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| C | GLU38 |
| C | PHE42 |
| D | HOH403 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ACY C 303 |
| Chain | Residue |
| C | ASP63 |
| C | MSE100 |
| C | TYR175 |
| C | GLY233 |
| D | GLU52 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue ACY D 301 |
| Chain | Residue |
| C | GLU52 |
| D | ASP63 |
| D | TYR175 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue PEG E 301 |
| Chain | Residue |
| E | LYS116 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ACY E 302 |
| Chain | Residue |
| E | ILE67 |
| E | MSE100 |
| E | TYR175 |
| F | GLU52 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ACY E 303 |
| Chain | Residue |
| E | GLU52 |
| F | ILE67 |
| F | TYR175 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ACY G 301 |
| Chain | Residue |
| G | MSE100 |
| G | TYR175 |
| G | HOH408 |
| H | GLU52 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACY H 301 |
| Chain | Residue |
| G | GLU52 |
| H | ASP63 |
| H | TYR175 |
| H | GLY233 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ACY I 301 |
| Chain | Residue |
| I | ASP63 |
| I | MSE100 |
| I | TYR175 |
| J | GLU52 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ACY J 301 |
| Chain | Residue |
| I | GLU52 |
| J | ILE67 |
| J | MSE100 |
| J | TYR175 |
| J | HOH420 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGiPFSDPVADG |
| Chain | Residue | Details |
| A | ILE51-GLY64 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
