Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QKY

Tryptophan synthase subunit alpha from Streptococcus pneumoniae with 3D domain swap in the core of TIM barrel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0004834	molecular_function	tryptophan synthase activity
A	0005829	cellular_component	cytosol
A	0006568	biological_process	L-tryptophan metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
B	0000162	biological_process	L-tryptophan biosynthetic process
B	0004834	molecular_function	tryptophan synthase activity
B	0005829	cellular_component	cytosol
B	0006568	biological_process	L-tryptophan metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016829	molecular_function	lyase activity
C	0000162	biological_process	L-tryptophan biosynthetic process
C	0004834	molecular_function	tryptophan synthase activity
C	0005829	cellular_component	cytosol
C	0006568	biological_process	L-tryptophan metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016829	molecular_function	lyase activity
D	0000162	biological_process	L-tryptophan biosynthetic process
D	0004834	molecular_function	tryptophan synthase activity
D	0005829	cellular_component	cytosol
D	0006568	biological_process	L-tryptophan metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016829	molecular_function	lyase activity
E	0000162	biological_process	L-tryptophan biosynthetic process
E	0004834	molecular_function	tryptophan synthase activity
E	0005829	cellular_component	cytosol
E	0006568	biological_process	L-tryptophan metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0016829	molecular_function	lyase activity
F	0000162	biological_process	L-tryptophan biosynthetic process
F	0004834	molecular_function	tryptophan synthase activity
F	0005829	cellular_component	cytosol
F	0006568	biological_process	L-tryptophan metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0016829	molecular_function	lyase activity
G	0000162	biological_process	L-tryptophan biosynthetic process
G	0004834	molecular_function	tryptophan synthase activity
G	0005829	cellular_component	cytosol
G	0006568	biological_process	L-tryptophan metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0016829	molecular_function	lyase activity
H	0000162	biological_process	L-tryptophan biosynthetic process
H	0004834	molecular_function	tryptophan synthase activity
H	0005829	cellular_component	cytosol
H	0006568	biological_process	L-tryptophan metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0016829	molecular_function	lyase activity
I	0000162	biological_process	L-tryptophan biosynthetic process
I	0004834	molecular_function	tryptophan synthase activity
I	0005829	cellular_component	cytosol
I	0006568	biological_process	L-tryptophan metabolic process
I	0008652	biological_process	amino acid biosynthetic process
I	0009073	biological_process	aromatic amino acid family biosynthetic process
I	0016829	molecular_function	lyase activity
J	0000162	biological_process	L-tryptophan biosynthetic process
J	0004834	molecular_function	tryptophan synthase activity
J	0005829	cellular_component	cytosol
J	0006568	biological_process	L-tryptophan metabolic process
J	0008652	biological_process	amino acid biosynthetic process
J	0009073	biological_process	aromatic amino acid family biosynthetic process
J	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue GOL A 301

Chain	Residue
A	LYS8

site_id	AC2
Number of Residues	4
Details	binding site for residue ACY A 302

Chain	Residue
A	ASP63
A	MSE100
A	TYR175
B	GLU52

site_id	AC3
Number of Residues	3
Details	binding site for residue PEG B 301

Chain	Residue
B	GLU38
B	THR39
B	HOH410

site_id	AC4
Number of Residues	7
Details	binding site for residue ACY B 302

Chain	Residue
B	ASP63
B	ILE67
B	MSE100
B	TYR175
B	GLY233
C	LYS185
A	GLU52

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL C 301

Chain	Residue
C	GLU86
C	LYS89
C	ASP117

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL C 302

Chain	Residue
C	GLU38
C	PHE42
D	HOH403

site_id	AC7
Number of Residues	5
Details	binding site for residue ACY C 303

Chain	Residue
C	ASP63
C	MSE100
C	TYR175
C	GLY233
D	GLU52

site_id	AC8
Number of Residues	3
Details	binding site for residue ACY D 301

Chain	Residue
C	GLU52
D	ASP63
D	TYR175

site_id	AC9
Number of Residues	1
Details	binding site for residue PEG E 301

Chain	Residue
E	LYS116

site_id	AD1
Number of Residues	4
Details	binding site for residue ACY E 302

Chain	Residue
E	ILE67
E	MSE100
E	TYR175
F	GLU52

site_id	AD2
Number of Residues	3
Details	binding site for residue ACY E 303

Chain	Residue
E	GLU52
F	ILE67
F	TYR175

site_id	AD3
Number of Residues	4
Details	binding site for residue ACY G 301

Chain	Residue
G	MSE100
G	TYR175
G	HOH408
H	GLU52

site_id	AD4
Number of Residues	4
Details	binding site for residue ACY H 301

Chain	Residue
G	GLU52
H	ASP63
H	TYR175
H	GLY233

site_id	AD5
Number of Residues	4
Details	binding site for residue ACY I 301

Chain	Residue
I	ASP63
I	MSE100
I	TYR175
J	GLU52

site_id	AD6
Number of Residues	5
Details	binding site for residue ACY J 301

Chain	Residue
I	GLU52
J	ILE67
J	MSE100
J	TYR175
J	HOH420

Functional Information from PROSITE/UniProt

site_id	PS00167
Number of Residues	14
Details	TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGiPFSDPVADG

Chain	Residue	Details
A	ILE51-GLY64

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00131","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)