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6QKC

GluA1/2 In complex with auxiliary subunit gamma-8

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0001919biological_processregulation of receptor recycling
A0001965molecular_functionG-protein alpha-subunit binding
A0004970molecular_functionglutamate-gated receptor activity
A0004971molecular_functionAMPA glutamate receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0006811biological_processmonoatomic ion transport
A0007268biological_processchemical synaptic transmission
A0007416biological_processsynapse assembly
A0007616biological_processlong-term memory
A0008021cellular_componentsynaptic vesicle
A0008179molecular_functionadenylate cyclase binding
A0008328cellular_componentionotropic glutamate receptor complex
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0009986cellular_componentcell surface
A0010226biological_processresponse to lithium ion
A0010628biological_processpositive regulation of gene expression
A0014069cellular_componentpostsynaptic density
A0014070biological_processresponse to organic cyclic compound
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0019228biological_processneuronal action potential
A0019722biological_processcalcium-mediated signaling
A0019865molecular_functionimmunoglobulin binding
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0021510biological_processspinal cord development
A0021987biological_processcerebral cortex development
A0022849molecular_functionglutamate-gated calcium ion channel activity
A0022890molecular_functioninorganic cation transmembrane transporter activity
A0030165molecular_functionPDZ domain binding
A0030425cellular_componentdendrite
A0030672cellular_componentsynaptic vesicle membrane
A0031267molecular_functionsmall GTPase binding
A0031489molecular_functionmyosin V binding
A0031594cellular_componentneuromuscular junction
A0031623biological_processreceptor internalization
A0031681molecular_functionG-protein beta-subunit binding
A0031698molecular_functionbeta-2 adrenergic receptor binding
A0031901cellular_componentearly endosome membrane
A0032279cellular_componentasymmetric synapse
A0032281cellular_componentAMPA glutamate receptor complex
A0032355biological_processresponse to estradiol
A0032590cellular_componentdendrite membrane
A0032591cellular_componentdendritic spine membrane
A0032809cellular_componentneuronal cell body membrane
A0032991cellular_componentprotein-containing complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0035254molecular_functionglutamate receptor binding
A0036477cellular_componentsomatodendritic compartment
A0038023molecular_functionsignaling receptor activity
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043226cellular_componentorganelle
A0043278biological_processresponse to morphine
A0043434biological_processresponse to peptide hormone
A0044297cellular_componentcell body
A0044308cellular_componentaxonal spine
A0044309cellular_componentneuron spine
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045838biological_processpositive regulation of membrane potential
A0046685biological_processresponse to arsenic-containing substance
A0048167biological_processregulation of synaptic plasticity
A0048266biological_processbehavioral response to pain
A0048787cellular_componentpresynaptic active zone membrane
A0050804biological_processmodulation of chemical synaptic transmission
A0050806biological_processpositive regulation of synaptic transmission
A0051018molecular_functionprotein kinase A binding
A0051602biological_processresponse to electrical stimulus
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060076cellular_componentexcitatory synapse
A0060078biological_processregulation of postsynaptic membrane potential
A0060291biological_processlong-term synaptic potentiation
A0060292biological_processlong-term synaptic depression
A0060992biological_processresponse to fungicide
A0071230biological_processcellular response to amino acid stimulus
A0071242biological_processcellular response to ammonium ion
A0071359biological_processcellular response to dsRNA
A0071363biological_processcellular response to growth factor stimulus
A0071375biological_processcellular response to peptide hormone stimulus
A0071407biological_processcellular response to organic cyclic compound
A0071418biological_processcellular response to amine stimulus
A0097060cellular_componentsynaptic membrane
A0097110molecular_functionscaffold protein binding
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099092cellular_componentpostsynaptic density, intracellular component
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A0099544cellular_componentperisynaptic space
A0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
A0099583molecular_functionneurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0001540molecular_functionamyloid-beta binding
C0001919biological_processregulation of receptor recycling
C0001965molecular_functionG-protein alpha-subunit binding
C0004970molecular_functionglutamate-gated receptor activity
C0004971molecular_functionAMPA glutamate receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005515molecular_functionprotein binding
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0006811biological_processmonoatomic ion transport
C0007268biological_processchemical synaptic transmission
C0007416biological_processsynapse assembly
C0007616biological_processlong-term memory
C0008021cellular_componentsynaptic vesicle
C0008179molecular_functionadenylate cyclase binding
C0008328cellular_componentionotropic glutamate receptor complex
C0009410biological_processresponse to xenobiotic stimulus
C0009636biological_processresponse to toxic substance
C0009986cellular_componentcell surface
C0010226biological_processresponse to lithium ion
C0010628biological_processpositive regulation of gene expression
C0014069cellular_componentpostsynaptic density
C0014070biological_processresponse to organic cyclic compound
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0019228biological_processneuronal action potential
C0019722biological_processcalcium-mediated signaling
C0019865molecular_functionimmunoglobulin binding
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0021510biological_processspinal cord development
C0021987biological_processcerebral cortex development
C0022849molecular_functionglutamate-gated calcium ion channel activity
C0022890molecular_functioninorganic cation transmembrane transporter activity
C0030165molecular_functionPDZ domain binding
C0030425cellular_componentdendrite
C0030672cellular_componentsynaptic vesicle membrane
C0031267molecular_functionsmall GTPase binding
C0031489molecular_functionmyosin V binding
C0031594cellular_componentneuromuscular junction
C0031623biological_processreceptor internalization
C0031681molecular_functionG-protein beta-subunit binding
C0031698molecular_functionbeta-2 adrenergic receptor binding
C0031901cellular_componentearly endosome membrane
C0032279cellular_componentasymmetric synapse
C0032281cellular_componentAMPA glutamate receptor complex
C0032355biological_processresponse to estradiol
C0032590cellular_componentdendrite membrane
C0032591cellular_componentdendritic spine membrane
C0032809cellular_componentneuronal cell body membrane
C0032991cellular_componentprotein-containing complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0035254molecular_functionglutamate receptor binding
C0036477cellular_componentsomatodendritic compartment
C0038023molecular_functionsignaling receptor activity
C0042220biological_processresponse to cocaine
C0042734cellular_componentpresynaptic membrane
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043198cellular_componentdendritic shaft
C0043226cellular_componentorganelle
C0043278biological_processresponse to morphine
C0043434biological_processresponse to peptide hormone
C0044297cellular_componentcell body
C0044308cellular_componentaxonal spine
C0044309cellular_componentneuron spine
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045838biological_processpositive regulation of membrane potential
C0046685biological_processresponse to arsenic-containing substance
C0048167biological_processregulation of synaptic plasticity
C0048266biological_processbehavioral response to pain
C0048787cellular_componentpresynaptic active zone membrane
C0050804biological_processmodulation of chemical synaptic transmission
C0050806biological_processpositive regulation of synaptic transmission
C0051018molecular_functionprotein kinase A binding
C0051602biological_processresponse to electrical stimulus
C0055037cellular_componentrecycling endosome
C0055038cellular_componentrecycling endosome membrane
C0060076cellular_componentexcitatory synapse
C0060078biological_processregulation of postsynaptic membrane potential
C0060291biological_processlong-term synaptic potentiation
C0060292biological_processlong-term synaptic depression
C0060992biological_processresponse to fungicide
C0071230biological_processcellular response to amino acid stimulus
C0071242biological_processcellular response to ammonium ion
C0071359biological_processcellular response to dsRNA
C0071363biological_processcellular response to growth factor stimulus
C0071375biological_processcellular response to peptide hormone stimulus
C0071407biological_processcellular response to organic cyclic compound
C0071418biological_processcellular response to amine stimulus
C0097060cellular_componentsynaptic membrane
C0097110molecular_functionscaffold protein binding
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099092cellular_componentpostsynaptic density, intracellular component
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C0099544cellular_componentperisynaptic space
C0099566biological_processregulation of postsynaptic cytosolic calcium ion concentration
C0099583molecular_functionneurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
I0005245molecular_functionvoltage-gated calcium channel activity
I0005246molecular_functioncalcium channel regulator activity
I0005262molecular_functioncalcium channel activity
I0005515molecular_functionprotein binding
I0005886cellular_componentplasma membrane
I0006816biological_processcalcium ion transport
I0014069cellular_componentpostsynaptic density
I0016020cellular_componentmembrane
I0016247molecular_functionchannel regulator activity
I0019226biological_processtransmission of nerve impulse
I0030346molecular_functionprotein phosphatase 2B binding
I0032281cellular_componentAMPA glutamate receptor complex
I0032590cellular_componentdendrite membrane
I0034702cellular_componentmonoatomic ion channel complex
I0035255molecular_functionionotropic glutamate receptor binding
I0045202cellular_componentsynapse
I0045211cellular_componentpostsynaptic membrane
I0051968biological_processpositive regulation of synaptic transmission, glutamatergic
I0070588biological_processcalcium ion transmembrane transport
I0098685cellular_componentSchaffer collateral - CA1 synapse
I0098839cellular_componentpostsynaptic density membrane
I0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
I0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
I0098978cellular_componentglutamatergic synapse
I0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
I0099590biological_processneurotransmitter receptor internalization
I1990454cellular_componentL-type voltage-gated calcium channel complex
I2000311biological_processregulation of AMPA receptor activity
J0005245molecular_functionvoltage-gated calcium channel activity
J0005246molecular_functioncalcium channel regulator activity
J0005262molecular_functioncalcium channel activity
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0006816biological_processcalcium ion transport
J0014069cellular_componentpostsynaptic density
J0016020cellular_componentmembrane
J0016247molecular_functionchannel regulator activity
J0019226biological_processtransmission of nerve impulse
J0030346molecular_functionprotein phosphatase 2B binding
J0032281cellular_componentAMPA glutamate receptor complex
J0032590cellular_componentdendrite membrane
J0034702cellular_componentmonoatomic ion channel complex
J0035255molecular_functionionotropic glutamate receptor binding
J0045202cellular_componentsynapse
J0045211cellular_componentpostsynaptic membrane
J0051968biological_processpositive regulation of synaptic transmission, glutamatergic
J0070588biological_processcalcium ion transmembrane transport
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098839cellular_componentpostsynaptic density membrane
J0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
J0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
J0098978cellular_componentglutamatergic synapse
J0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
J0099590biological_processneurotransmitter receptor internalization
J1990454cellular_componentL-type voltage-gated calcium channel complex
J2000311biological_processregulation of AMPA receptor activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue E2Q A 901
ChainResidue
ATYR446
APRO474
ALEU475
ATHR476
AARG481
ATHR682
AGLU701
AMET704
ATYR728

site_idAC2
Number of Residues1
Detailsbinding site for residue OLC A 903
ChainResidue
APHE511

site_idAC3
Number of Residues9
Detailsbinding site for residue E2Q B 901
ChainResidue
BTYR450
BPRO478
BLEU479
BTHR480
BARG485
BTHR686
BGLU705
BMET708
BTYR732

site_idAC4
Number of Residues9
Detailsbinding site for residue E2Q C 901
ChainResidue
CTYR446
CPRO474
CLEU475
CTHR476
CARG481
CTHR682
CGLU701
CMET704
CTYR728

site_idAC5
Number of Residues1
Detailsbinding site for residue OLC C 903
ChainResidue
CPHE511

site_idAC6
Number of Residues9
Detailsbinding site for residue E2Q D 901
ChainResidue
DTYR450
DPRO478
DLEU479
DTHR480
DARG485
DTHR686
DGLU705
DMET708
DTYR732

site_idAC7
Number of Residues1
Detailsbinding site for residue OLC I 501
ChainResidue
IOLC502

site_idAC8
Number of Residues1
Detailsbinding site for residue OLC I 502
ChainResidue
IOLC501

site_idAC9
Number of Residues1
Detailsbinding site for residue OLC J 501
ChainResidue
JOLC502

site_idAD1
Number of Residues1
Detailsbinding site for residue OLC J 502
ChainResidue
JOLC501

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
IVAL19-ILE39
JVAL318-GLY338
ISER127-ALA147
IILE157-ILE177
IPHE207-ILE227
IVAL318-GLY338
JVAL19-ILE39
JSER127-ALA147
JILE157-ILE177
JPHE207-ILE227

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ISER251
ISER254
JSER251
JSER254

site_idSWS_FT_FI3
Number of Residues62
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
BSER544-GLU570
BASP590-SER595
DSER544-GLU570
DASP590-SER595
CASP586-SER591
CGLU809-LEU889

site_idSWS_FT_FI4
Number of Residues30
DetailsINTRAMEM: Helical; Pore-forming
ChainResidueDetails
BPHE571-ARG586
DPHE571-ARG586

site_idSWS_FT_FI5
Number of Residues4
DetailsINTRAMEM:
ChainResidueDetails
BGLN587-CYS589
DGLN587-CYS589

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=M4
ChainResidueDetails
BVAL792-ILE812
DVAL792-ILE812

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
BPRO478
DSER654
DTHR655
DGLU705
BTHR480
BARG485
BSER654
BTHR655
BGLU705
DPRO478
DTHR480
DARG485

site_idSWS_FT_FI8
Number of Residues6
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
BARG453
BARG660
BLYS752
DARG453
DARG660
DLYS752

site_idSWS_FT_FI9
Number of Residues2
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
BILE633
DILE633

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
BSER662
DSER662

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
BSER696
DSER696

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819
ChainResidueDetails
BSER839
DSER839
CCYS585
CCYS811

site_idSWS_FT_FI13
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
BCYS589
BCYS815
DCYS589
DCYS815
CASN45
CASN231
CASN239
CASN345

site_idSWS_FT_FI14
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
ChainResidueDetails
BASN235
DASN235
CASN383
CASN388

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
ChainResidueDetails
BASN349
DASN349

site_idSWS_FT_FI16
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN385
BASN392
DASN385
DASN392

221716

PDB entries from 2024-06-26

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