6QK7
Elongator catalytic subcomplex Elp123 lobe
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0002098 | biological_process | tRNA wobble uridine modification |
| A | 0002926 | biological_process | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0006417 | biological_process | regulation of translation |
| A | 0008033 | biological_process | tRNA processing |
| A | 0015031 | biological_process | protein transport |
| A | 0033588 | cellular_component | elongator holoenzyme complex |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0002098 | biological_process | tRNA wobble uridine modification |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006417 | biological_process | regulation of translation |
| B | 0008017 | molecular_function | microtubule binding |
| B | 0008033 | biological_process | tRNA processing |
| B | 0015031 | biological_process | protein transport |
| B | 0032447 | biological_process | protein urmylation |
| B | 0033588 | cellular_component | elongator holoenzyme complex |
| B | 0080090 | biological_process | regulation of primary metabolic process |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0002098 | biological_process | tRNA wobble uridine modification |
| C | 0002926 | biological_process | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006417 | biological_process | regulation of translation |
| C | 0008033 | biological_process | tRNA processing |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0033588 | cellular_component | elongator holoenzyme complex |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0106261 | molecular_function | tRNA uridine(34) acetyltransferase activity |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0002098 | biological_process | tRNA wobble uridine modification |
| D | 0002926 | biological_process | tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| D | 0006417 | biological_process | regulation of translation |
| D | 0008033 | biological_process | tRNA processing |
| D | 0015031 | biological_process | protein transport |
| D | 0033588 | cellular_component | elongator holoenzyme complex |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SF4 C 601 |
| Chain | Residue |
| C | CYS108 |
| C | HIS110 |
| C | CYS118 |
| C | CYS121 |
| C | ARG269 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue 5AD C 602 |
| Chain | Residue |
| C | TYR327 |
| C | PRO328 |
| C | LEU330 |
| C | ARG376 |
| C | TYR120 |
| C | GLN257 |
| C | HIS293 |
| C | MET295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"25569479","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"WD 8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"WD 9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"WD 10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"WD 13","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16420352","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31309145","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6QK7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"A0A1C7D1B7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12872131","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
