Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QI8

Truncated human R2TP complex, structure 3 (ADP-filled)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000492	biological_process	box C/D snoRNP assembly
A	0000723	biological_process	telomere maintenance
A	0000786	cellular_component	nucleosome
A	0000812	cellular_component	Swr1 complex
A	0001094	molecular_function	TFIID-class transcription factor complex binding
A	0003678	molecular_function	DNA helicase activity
A	0003713	molecular_function	transcription coactivator activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006310	biological_process	DNA recombination
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0007283	biological_process	spermatogenesis
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0016020	cellular_component	membrane
A	0016363	cellular_component	nuclear matrix
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017025	molecular_function	TBP-class protein binding
A	0031011	cellular_component	Ino80 complex
A	0032508	biological_process	DNA duplex unwinding
A	0033044	biological_process	regulation of chromosome organization
A	0035267	cellular_component	NuA4 histone acetyltransferase complex
A	0042981	biological_process	regulation of apoptotic process
A	0043531	molecular_function	ADP binding
A	0045296	molecular_function	cadherin binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0050821	biological_process	protein stabilization
A	0051117	molecular_function	ATPase binding
A	0051276	biological_process	chromosome organization
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0060382	biological_process	regulation of DNA strand elongation
A	0070062	cellular_component	extracellular exosome
A	0071339	cellular_component	MLL1 complex
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0097255	cellular_component	R2TP complex
A	0101031	cellular_component	protein folding chaperone complex
A	0120293	cellular_component	dynein axonemal particle
A	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
A	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
A	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
A	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
A	1990904	cellular_component	ribonucleoprotein complex
A	2000779	biological_process	regulation of double-strand break repair
B	0000492	biological_process	box C/D snoRNP assembly
B	0000723	biological_process	telomere maintenance
B	0000786	cellular_component	nucleosome
B	0000812	cellular_component	Swr1 complex
B	0001094	molecular_function	TFIID-class transcription factor complex binding
B	0003678	molecular_function	DNA helicase activity
B	0003713	molecular_function	transcription coactivator activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006282	biological_process	regulation of DNA repair
B	0006310	biological_process	DNA recombination
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007283	biological_process	spermatogenesis
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016020	cellular_component	membrane
B	0016363	cellular_component	nuclear matrix
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017025	molecular_function	TBP-class protein binding
B	0031011	cellular_component	Ino80 complex
B	0032508	biological_process	DNA duplex unwinding
B	0033044	biological_process	regulation of chromosome organization
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0042981	biological_process	regulation of apoptotic process
B	0043531	molecular_function	ADP binding
B	0045296	molecular_function	cadherin binding
B	0045739	biological_process	positive regulation of DNA repair
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0045995	biological_process	regulation of embryonic development
B	0050821	biological_process	protein stabilization
B	0051117	molecular_function	ATPase binding
B	0051276	biological_process	chromosome organization
B	0051301	biological_process	cell division
B	0051726	biological_process	regulation of cell cycle
B	0060382	biological_process	regulation of DNA strand elongation
B	0070062	cellular_component	extracellular exosome
B	0071339	cellular_component	MLL1 complex
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0097255	cellular_component	R2TP complex
B	0101031	cellular_component	protein folding chaperone complex
B	0120293	cellular_component	dynein axonemal particle
B	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
B	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
B	1990904	cellular_component	ribonucleoprotein complex
B	2000779	biological_process	regulation of double-strand break repair
C	0000492	biological_process	box C/D snoRNP assembly
C	0000723	biological_process	telomere maintenance
C	0000786	cellular_component	nucleosome
C	0000812	cellular_component	Swr1 complex
C	0001094	molecular_function	TFIID-class transcription factor complex binding
C	0003678	molecular_function	DNA helicase activity
C	0003713	molecular_function	transcription coactivator activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0006275	biological_process	regulation of DNA replication
C	0006281	biological_process	DNA repair
C	0006282	biological_process	regulation of DNA repair
C	0006310	biological_process	DNA recombination
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007283	biological_process	spermatogenesis
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0016020	cellular_component	membrane
C	0016363	cellular_component	nuclear matrix
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017025	molecular_function	TBP-class protein binding
C	0031011	cellular_component	Ino80 complex
C	0032508	biological_process	DNA duplex unwinding
C	0033044	biological_process	regulation of chromosome organization
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
C	0042981	biological_process	regulation of apoptotic process
C	0043531	molecular_function	ADP binding
C	0045296	molecular_function	cadherin binding
C	0045739	biological_process	positive regulation of DNA repair
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045995	biological_process	regulation of embryonic development
C	0050821	biological_process	protein stabilization
C	0051117	molecular_function	ATPase binding
C	0051276	biological_process	chromosome organization
C	0051301	biological_process	cell division
C	0051726	biological_process	regulation of cell cycle
C	0060382	biological_process	regulation of DNA strand elongation
C	0070062	cellular_component	extracellular exosome
C	0071339	cellular_component	MLL1 complex
C	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
C	0097255	cellular_component	R2TP complex
C	0101031	cellular_component	protein folding chaperone complex
C	0120293	cellular_component	dynein axonemal particle
C	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
C	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
C	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
C	1990904	cellular_component	ribonucleoprotein complex
C	2000779	biological_process	regulation of double-strand break repair
D	0000492	biological_process	box C/D snoRNP assembly
D	0000723	biological_process	telomere maintenance
D	0000786	cellular_component	nucleosome
D	0000791	cellular_component	euchromatin
D	0000812	cellular_component	Swr1 complex
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
D	0001094	molecular_function	TFIID-class transcription factor complex binding
D	0003678	molecular_function	DNA helicase activity
D	0003714	molecular_function	transcription corepressor activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0006275	biological_process	regulation of DNA replication
D	0006281	biological_process	DNA repair
D	0006282	biological_process	regulation of DNA repair
D	0006310	biological_process	DNA recombination
D	0006325	biological_process	chromatin organization
D	0006338	biological_process	chromatin remodeling
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006457	biological_process	protein folding
D	0008013	molecular_function	beta-catenin binding
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0016020	cellular_component	membrane
D	0016363	cellular_component	nuclear matrix
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017025	molecular_function	TBP-class protein binding
D	0031011	cellular_component	Ino80 complex
D	0031490	molecular_function	chromatin DNA binding
D	0032508	biological_process	DNA duplex unwinding
D	0033044	biological_process	regulation of chromosome organization
D	0034644	biological_process	cellular response to UV
D	0035267	cellular_component	NuA4 histone acetyltransferase complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042981	biological_process	regulation of apoptotic process
D	0043531	molecular_function	ADP binding
D	0045739	biological_process	positive regulation of DNA repair
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0045995	biological_process	regulation of embryonic development
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
D	0051117	molecular_function	ATPase binding
D	0051276	biological_process	chromosome organization
D	0051726	biological_process	regulation of cell cycle
D	0060382	biological_process	regulation of DNA strand elongation
D	0070062	cellular_component	extracellular exosome
D	0071169	biological_process	establishment of protein localization to chromatin
D	0071339	cellular_component	MLL1 complex
D	0071392	biological_process	cellular response to estradiol stimulus
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0097255	cellular_component	R2TP complex
D	0101031	cellular_component	protein folding chaperone complex
D	0120293	cellular_component	dynein axonemal particle
D	0140585	molecular_function	promoter-enhancer loop anchoring activity
D	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
D	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
D	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
D	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
D	1990904	cellular_component	ribonucleoprotein complex
D	2000779	biological_process	regulation of double-strand break repair
E	0000492	biological_process	box C/D snoRNP assembly
E	0000723	biological_process	telomere maintenance
E	0000786	cellular_component	nucleosome
E	0000791	cellular_component	euchromatin
E	0000812	cellular_component	Swr1 complex
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
E	0001094	molecular_function	TFIID-class transcription factor complex binding
E	0003678	molecular_function	DNA helicase activity
E	0003714	molecular_function	transcription corepressor activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006282	biological_process	regulation of DNA repair
E	0006310	biological_process	DNA recombination
E	0006325	biological_process	chromatin organization
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006457	biological_process	protein folding
E	0008013	molecular_function	beta-catenin binding
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0016020	cellular_component	membrane
E	0016363	cellular_component	nuclear matrix
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017025	molecular_function	TBP-class protein binding
E	0031011	cellular_component	Ino80 complex
E	0031490	molecular_function	chromatin DNA binding
E	0032508	biological_process	DNA duplex unwinding
E	0033044	biological_process	regulation of chromosome organization
E	0034644	biological_process	cellular response to UV
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042981	biological_process	regulation of apoptotic process
E	0043531	molecular_function	ADP binding
E	0045739	biological_process	positive regulation of DNA repair
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0045995	biological_process	regulation of embryonic development
E	0050821	biological_process	protein stabilization
E	0051082	molecular_function	unfolded protein binding
E	0051117	molecular_function	ATPase binding
E	0051276	biological_process	chromosome organization
E	0051726	biological_process	regulation of cell cycle
E	0060382	biological_process	regulation of DNA strand elongation
E	0070062	cellular_component	extracellular exosome
E	0071169	biological_process	establishment of protein localization to chromatin
E	0071339	cellular_component	MLL1 complex
E	0071392	biological_process	cellular response to estradiol stimulus
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0097255	cellular_component	R2TP complex
E	0101031	cellular_component	protein folding chaperone complex
E	0120293	cellular_component	dynein axonemal particle
E	0140585	molecular_function	promoter-enhancer loop anchoring activity
E	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
E	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
E	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
E	1990904	cellular_component	ribonucleoprotein complex
E	2000779	biological_process	regulation of double-strand break repair
F	0000492	biological_process	box C/D snoRNP assembly
F	0000723	biological_process	telomere maintenance
F	0000786	cellular_component	nucleosome
F	0000791	cellular_component	euchromatin
F	0000812	cellular_component	Swr1 complex
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0003678	molecular_function	DNA helicase activity
F	0003714	molecular_function	transcription corepressor activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006282	biological_process	regulation of DNA repair
F	0006310	biological_process	DNA recombination
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006457	biological_process	protein folding
F	0008013	molecular_function	beta-catenin binding
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0016020	cellular_component	membrane
F	0016363	cellular_component	nuclear matrix
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017025	molecular_function	TBP-class protein binding
F	0031011	cellular_component	Ino80 complex
F	0031490	molecular_function	chromatin DNA binding
F	0032508	biological_process	DNA duplex unwinding
F	0033044	biological_process	regulation of chromosome organization
F	0034644	biological_process	cellular response to UV
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042981	biological_process	regulation of apoptotic process
F	0043531	molecular_function	ADP binding
F	0045739	biological_process	positive regulation of DNA repair
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0045995	biological_process	regulation of embryonic development
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding
F	0051117	molecular_function	ATPase binding
F	0051276	biological_process	chromosome organization
F	0051726	biological_process	regulation of cell cycle
F	0060382	biological_process	regulation of DNA strand elongation
F	0070062	cellular_component	extracellular exosome
F	0071169	biological_process	establishment of protein localization to chromatin
F	0071339	cellular_component	MLL1 complex
F	0071392	biological_process	cellular response to estradiol stimulus
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0097255	cellular_component	R2TP complex
F	0101031	cellular_component	protein folding chaperone complex
F	0120293	cellular_component	dynein axonemal particle
F	0140585	molecular_function	promoter-enhancer loop anchoring activity
F	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage
F	1904874	biological_process	positive regulation of telomerase RNA localization to Cajal body
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
F	1990062	cellular_component	RPAP3/R2TP/prefoldin-like complex
F	1990904	cellular_component	ribonucleoprotein complex
F	2000779	biological_process	regulation of double-strand break repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ADP A 501

Chain	Residue
A	SER17
A	GLY75
A	LYS76
A	THR77
A	TYR366
A	ILE374
A	LEU403
A	ARG404
A	HIS18
A	HIS20
A	GLY38
A	LEU39
A	VAL40
A	PRO72
A	GLY73
A	THR74

site_id	AC2
Number of Residues	16
Details	binding site for residue ADP B 501

Chain	Residue
B	SER17
B	HIS18
B	HIS20
B	GLY38
B	LEU39
B	VAL40
B	GLY73
B	THR74
B	GLY75
B	LYS76
B	THR77
B	ALA78
B	TYR366
B	ILE374
B	LEU403
B	ARG404

site_id	AC3
Number of Residues	17
Details	binding site for Di-peptide ADP C 501 and GLY C 75

Chain	Residue
C	SER17
C	HIS18
C	HIS20
C	GLY38
C	LEU39
C	VAL40
C	PRO72
C	GLY73
C	THR74
C	LYS76
C	THR77
C	ALA78
C	LEU79
C	TYR366
C	ILE374
C	LEU403
C	ARG404

site_id	AC4
Number of Residues	20
Details	binding site for Di-peptide ADP C 501 and ARG C 404

Chain	Residue
C	SER17
C	HIS18
C	HIS20
C	GLY38
C	LEU39
C	VAL40
C	PRO72
C	GLY73
C	THR74
C	GLY75
C	LYS76
C	THR77
C	TYR366
C	ILE374
C	THR402
C	LEU403
C	TYR405
C	SER406
C	VAL407
C	GLN408

site_id	AC5
Number of Residues	16
Details	binding site for Di-peptide ADP D 501 and TYR D 362

Chain	Residue
D	ALA24
D	HIS25
D	HIS27
D	VAL47
D	GLN49
D	PRO79
D	GLY80
D	THR81
D	GLY82
D	LYS83
D	THR84
D	PRO361
D	SER363
D	THR367
D	ILE370
D	LEU399

site_id	AC6
Number of Residues	16
Details	binding site for Di-peptide ADP D 501 and THR D 81

Chain	Residue
D	ILE370
D	LEU399
D	ALA24
D	HIS25
D	HIS27
D	VAL47
D	GLN49
D	GLN78
D	PRO79
D	GLY80
D	GLY82
D	LYS83
D	THR84
D	THR359
D	THR360
D	TYR362

site_id	AC7
Number of Residues	16
Details	binding site for Di-peptide ADP D 501 and TYR D 362

Chain	Residue
D	ALA24
D	HIS25
D	HIS27
D	VAL47
D	GLN49
D	PRO79
D	GLY80
D	THR81
D	GLY82
D	LYS83
D	THR84
D	PRO361
D	SER363
D	THR367
D	ILE370
D	LEU399

site_id	AC8
Number of Residues	13
Details	binding site for Di-peptide ADP D 501 and GLY D 80

Chain	Residue
D	ALA24
D	HIS25
D	HIS27
D	VAL47
D	GLN49
D	PRO79
D	THR81
D	GLY82
D	LYS83
D	THR84
D	TYR362
D	ILE370
D	LEU399

site_id	AC9
Number of Residues	16
Details	binding site for Di-peptide ADP E 501 and TYR E 362

Chain	Residue
E	HIS25
E	HIS27
E	GLY45
E	MET46
E	VAL47
E	GLY48
E	PRO79
E	GLY80
E	THR81
E	GLY82
E	LYS83
E	THR84
E	PRO361
E	SER363
E	ILE370
E	LEU399

site_id	AD1
Number of Residues	18
Details	binding site for Di-peptide ADP F 501 and TYR F 362

Chain	Residue
F	HIS25
F	HIS27
F	MET46
F	VAL47
F	GLN49
F	PRO79
F	GLY80
F	THR81
F	GLY82
F	LYS83
F	THR84
F	THR360
F	PRO361
F	SER363
F	ASP366
F	ILE370
F	LEU399
F	ARG400

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
D	GLY77
E	GLY77
F	GLY77

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.14, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22814378, ECO:0007744\|PubMed:25944712

Chain	Residue	Details
D	ALA2
E	ALA2
F	ALA2

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
D	SER437
E	SER437
F	SER437

site_id	SWS_FT_FI4
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
D	LYS9
F	LYS444
F	LYS456
A	LYS445
D	LYS444
D	LYS456
E	LYS9
C	LYS445
E	LYS444
E	LYS456
F	LYS9

site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS225
B	LYS225
C	LYS225

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)