6QI4

NCS-1 bound to a ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005245	molecular_function	voltage-gated calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
B	0009966	biological_process	regulation of signal transduction
B	0010975	biological_process	regulation of neuron projection development
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070588	biological_process	calcium ion transmembrane transport
C	0005245	molecular_function	voltage-gated calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
C	0009966	biological_process	regulation of signal transduction
C	0010975	biological_process	regulation of neuron projection development
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA B 201

Chain	Residue
B	ASP73
B	ASN75
B	ASP77
B	ARG79
B	GLU84
B	HOH334

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA B 202

Chain	Residue
B	TYR115
B	GLU120
B	HOH380
B	ASP109
B	ASP111
B	ASP113

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA B 203

Chain	Residue
B	ASP157
B	ASN159
B	ASP161
B	LYS163
B	GLU168
B	HOH315

---

site_id	AC4
Number of Residues	7
Details	binding site for residue P6G B 204

Chain	Residue
B	PHE22
B	GLN29
B	TRP30
B	SER93
B	ARG94
B	ASP187
B	HOH391

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NA B 205

Chain	Residue
B	THR17
B	THR20
B	PHE22

---

site_id	AC6
Number of Residues	6
Details	binding site for residue DMS B 206

Chain	Residue
B	MET155
B	LYS158
B	GLU171
B	GLY172
B	HOH310
B	HOH367

---

site_id	AC7
Number of Residues	3
Details	binding site for residue ACT B 207

Chain	Residue
B	LYS19
B	THR20
B	TYR21

---

site_id	AC8
Number of Residues	3
Details	binding site for residue 1PE B 208

Chain	Residue
B	THR92
B	LEU183
B	FKW212

---

site_id	AC9
Number of Residues	4
Details	binding site for residue 1PE B 209

Chain	Residue
B	ASP111
B	ASN112
B	HOH301
C	ASP123

---

site_id	AD1
Number of Residues	9
Details	binding site for residue 1PE B 210

Chain	Residue
B	TYR108
B	ARG148
B	ILE152
B	PHE169
B	SER173
B	LEU183
B	1PE211
B	HOH317
B	HOH319

---

site_id	AD2
Number of Residues	4
Details	binding site for residue 1PE B 211

Chain	Residue
B	ARG148
B	ASP176
B	SER178
B	1PE210

---

site_id	AD3
Number of Residues	8
Details	binding site for residue FKW B 212

Chain	Residue
B	TYR52
B	VAL68
B	PHE72
B	PHE85
B	TRP103
B	1PE208
B	HOH345
B	HOH398

---

site_id	AD4
Number of Residues	8
Details	binding site for residue P6G C 201

Chain	Residue
C	TYR108
C	TYR129
C	ARG148
C	PHE169
C	SER173
C	ILE179
C	HOH301
C	HOH338

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CA C 202

Chain	Residue
C	ASP73
C	ASN75
C	ASP77
C	ARG79
C	GLU84
C	HOH306

---

site_id	AD6
Number of Residues	6
Details	binding site for residue CA C 203

Chain	Residue
C	ASP109
C	ASP111
C	ASP113
C	TYR115
C	GLU120
C	HOH320

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CA C 204

Chain	Residue
C	ASP157
C	ASN159
C	ASP161
C	LYS163
C	GLU168
C	HOH323

---

site_id	AD8
Number of Residues	3
Details	binding site for residue NA C 205

Chain	Residue
C	THR17
C	THR20
C	PHE22

---

site_id	AD9
Number of Residues	4
Details	binding site for residue 1PE C 206

Chain	Residue
C	TYR52
C	PHE64
C	THR92
C	HOH307

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF

Chain	Residue	Details
B	ASP73-PHE85
B	ASP109-MET121
B	ASP157-PHE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	70
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	70
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62168","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---