6QI4
NCS-1 bound to a ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| B | 0010975 | biological_process | regulation of neuron projection development |
| B | 0014069 | cellular_component | postsynaptic density |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0005245 | molecular_function | voltage-gated calcium channel activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| C | 0010975 | biological_process | regulation of neuron projection development |
| C | 0014069 | cellular_component | postsynaptic density |
| C | 0030424 | cellular_component | axon |
| C | 0030425 | cellular_component | dendrite |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0045202 | cellular_component | synapse |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048471 | cellular_component | perinuclear region of cytoplasm |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 201 |
| Chain | Residue |
| B | ASP73 |
| B | ASN75 |
| B | ASP77 |
| B | ARG79 |
| B | GLU84 |
| B | HOH334 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 202 |
| Chain | Residue |
| B | TYR115 |
| B | GLU120 |
| B | HOH380 |
| B | ASP109 |
| B | ASP111 |
| B | ASP113 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 203 |
| Chain | Residue |
| B | ASP157 |
| B | ASN159 |
| B | ASP161 |
| B | LYS163 |
| B | GLU168 |
| B | HOH315 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue P6G B 204 |
| Chain | Residue |
| B | PHE22 |
| B | GLN29 |
| B | TRP30 |
| B | SER93 |
| B | ARG94 |
| B | ASP187 |
| B | HOH391 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 205 |
| Chain | Residue |
| B | THR17 |
| B | THR20 |
| B | PHE22 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS B 206 |
| Chain | Residue |
| B | MET155 |
| B | LYS158 |
| B | GLU171 |
| B | GLY172 |
| B | HOH310 |
| B | HOH367 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 207 |
| Chain | Residue |
| B | LYS19 |
| B | THR20 |
| B | TYR21 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE B 208 |
| Chain | Residue |
| B | THR92 |
| B | LEU183 |
| B | FKW212 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE B 209 |
| Chain | Residue |
| B | ASP111 |
| B | ASN112 |
| B | HOH301 |
| C | ASP123 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue 1PE B 210 |
| Chain | Residue |
| B | TYR108 |
| B | ARG148 |
| B | ILE152 |
| B | PHE169 |
| B | SER173 |
| B | LEU183 |
| B | 1PE211 |
| B | HOH317 |
| B | HOH319 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE B 211 |
| Chain | Residue |
| B | ARG148 |
| B | ASP176 |
| B | SER178 |
| B | 1PE210 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue FKW B 212 |
| Chain | Residue |
| B | TYR52 |
| B | VAL68 |
| B | PHE72 |
| B | PHE85 |
| B | TRP103 |
| B | 1PE208 |
| B | HOH345 |
| B | HOH398 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue P6G C 201 |
| Chain | Residue |
| C | TYR108 |
| C | TYR129 |
| C | ARG148 |
| C | PHE169 |
| C | SER173 |
| C | ILE179 |
| C | HOH301 |
| C | HOH338 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 202 |
| Chain | Residue |
| C | ASP73 |
| C | ASN75 |
| C | ASP77 |
| C | ARG79 |
| C | GLU84 |
| C | HOH306 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 203 |
| Chain | Residue |
| C | ASP109 |
| C | ASP111 |
| C | ASP113 |
| C | TYR115 |
| C | GLU120 |
| C | HOH320 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 204 |
| Chain | Residue |
| C | ASP157 |
| C | ASN159 |
| C | ASP161 |
| C | LYS163 |
| C | GLU168 |
| C | HOH323 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue NA C 205 |
| Chain | Residue |
| C | THR17 |
| C | THR20 |
| C | PHE22 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE C 206 |
| Chain | Residue |
| C | TYR52 |
| C | PHE64 |
| C | THR92 |
| C | HOH307 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF |
| Chain | Residue | Details |
| B | ASP73-PHE85 | |
| B | ASP109-MET121 | |
| B | ASP157-PHE169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| B | ASP73 | |
| B | GLU120 | |
| B | ASP157 | |
| B | ASN159 | |
| B | ASP161 | |
| B | LYS163 | |
| B | GLU168 | |
| C | ASP73 | |
| C | ASN75 | |
| C | ASP77 | |
| C | ARG79 | |
| B | ASN75 | |
| C | GLU84 | |
| C | ASP109 | |
| C | ASP111 | |
| C | ASP113 | |
| C | TYR115 | |
| C | GLU120 | |
| C | ASP157 | |
| C | ASN159 | |
| C | ASP161 | |
| C | LYS163 | |
| B | ASP77 | |
| C | GLU168 | |
| B | ARG79 | |
| B | GLU84 | |
| B | ASP109 | |
| B | ASP111 | |
| B | ASP113 | |
| B | TYR115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P62168 |
| Chain | Residue | Details |
| B | GLU81 | |
| C | GLU81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
| Chain | Residue | Details |
| B | GLY2 | |
| C | GLY2 |
