6QHP

Time resolved structural analysis of the full turnover of an enzyme - 2256 ms covalent intermediate 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016787	molecular_function	hydrolase activity
A	0018785	molecular_function	haloacetate dehalogenase activity
B	0003824	molecular_function	catalytic activity
B	0016787	molecular_function	hydrolase activity
B	0018785	molecular_function	haloacetate dehalogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue FAH A 401

Chain	Residue
A	PHE40
A	ILE253
A	HOH509
A	ASB110
A	ARG111
A	ARG114
A	ILE135
A	HIS155
A	TRP156
A	TRP185
A	TYR219

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site_id	AC2
Number of Residues	9
Details	binding site for residue FAH B 401

Chain	Residue
B	ASP110
B	ARG111
B	ARG114
B	ILE135
B	HIS155
B	TRP156
B	TYR219
B	ILE253
B	HOH525

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:21510690

Chain	Residue	Details
B	ASP110

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:21510690

Chain	Residue	Details
B	HIS280

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site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:21510690, ECO:0007744|PDB:3R3V

Chain	Residue	Details
B	ARG111
B	ARG114
B	HIS155
B	TRP156
B	TYR219

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for enzyme activity => ECO:0000305|PubMed:21510690

Chain	Residue	Details
B	ASP134

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