6QGV

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with a Spiro[4.5]decanone inhibitor (JPHM-2-167)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	J2H502
A	HOH626

---

site_id	AC2
Number of Residues	17
Details	binding site for residue J2H A 502

Chain	Residue
A	ASP315
A	ASP320
A	ARG322
A	HIS374
A	VAL376
A	TRP389
A	LYS402
A	TYR403
A	MN501
A	HOH626
A	HOH686
A	HOH707
A	HOH715
A	TRP258
A	THR296
A	TYR303
A	HIS313

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 503

Chain	Residue
A	LYS350
A	ALA351
A	GLN352
A	HOH605
A	HOH703
A	HOH716

---

site_id	AC4
Number of Residues	4
Details	binding site for residue IPA A 504

Chain	Residue
A	ASP277
A	ARG281
A	ASN293
A	GLY294

---

site_id	AC5
Number of Residues	12
Details	binding site for residue SO4 A 505

Chain	Residue
A	PRO264
A	PRO264
A	GLY265
A	GLY265
A	GLU267
A	GLU267
A	THR405
A	THR405
A	GLY406
A	GLY406
A	HOH683
A	HOH683

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 506

Chain	Residue
A	ARG344
A	ASP355
A	GLN377
A	GLN377

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	101
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---