6QGT

The carbon monoxide inhibition of F420-reducing [NiFe] hydrogenase complex from Methanosarcina barkeri

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008901	molecular_function	ferredoxin hydrogenase activity
A	0016151	molecular_function	nickel cation binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0050454	molecular_function	coenzyme F420 hydrogenase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0051536	molecular_function	iron-sulfur cluster binding
B	0000166	molecular_function	nucleotide binding
B	0016151	molecular_function	nickel cation binding
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0050454	molecular_function	coenzyme F420 hydrogenase activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0016151	molecular_function	nickel cation binding
G	0016491	molecular_function	oxidoreductase activity
G	0046872	molecular_function	metal ion binding
G	0050454	molecular_function	coenzyme F420 hydrogenase activity
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue SF4 G 301

Chain	Residue
A	ARG61
G	GLY144
G	CYS145
A	HIS162
G	GLY30
G	CYS31
G	CYS34
G	GLU76
G	SER105
G	CYS106
G	ASN111

---

site_id	AC2
Number of Residues	10
Details	binding site for residue SF4 G 302

Chain	Residue
G	CYS191
G	PHE192
G	CYS215
G	PRO216
G	CYS234
G	ILE235
G	CYS237
G	GLY238
G	SER239
G	CYS240

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SF4 G 303

Chain	Residue
G	CYS205
G	MET206
G	GLY207
G	CYS208
G	GLY209
G	THR210
G	CYS211
G	CYS244

---

site_id	AC4
Number of Residues	8
Details	binding site for residue FES G 304

Chain	Residue
G	CYS191
G	CYS191
G	CYS193
G	CYS193
G	ARG231
G	ARG231
G	LYS236
G	LYS236

---

site_id	AC5
Number of Residues	7
Details	binding site for residue 144 G 305

Chain	Residue
A	PRO9
G	TYR57
G	ARG65
G	HIS66
G	GLU85
G	ASP89
G	HOH476

---

site_id	AC6
Number of Residues	6
Details	binding site for residue BU3 G 306

Chain	Residue
B	GLN117
B	PRO127
G	ARG153
G	ASN154
G	SER261
G	HOH496

---

site_id	AC7
Number of Residues	2
Details	binding site for residue BU3 G 307

Chain	Residue
G	ASP40
G	HOH483

---

site_id	AC8
Number of Residues	14
Details	binding site for residue J52 A 501

Chain	Residue
A	CYS63
A	ILE65
A	CYS66
A	ALA69
A	HIS70
A	ALA378
A	PRO379
A	ARG380
A	ASN383
A	VAL401
A	PRO402
A	THR403
A	CYS432
A	CYS435

---

site_id	AC9
Number of Residues	6
Details	binding site for residue FE A 502

Chain	Residue
A	GLU44
A	MET399
A	HIS438
A	HOH614
A	HOH616
A	HOH628

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MG A 503

Chain	Residue
A	ASN322
A	ASN322
A	ASN322
A	HOH706
A	HOH706
A	HOH706

---

site_id	AD2
Number of Residues	6
Details	binding site for residue 144 A 504

Chain	Residue
A	ASN322
A	ASN322
A	ASN322
A	PHE323
A	PHE323
A	PHE323

---

site_id	AD3
Number of Residues	4
Details	binding site for residue MPD A 505

Chain	Residue
A	LEU128
A	PHE129
A	MET139
G	HOH456

---

site_id	AD4
Number of Residues	6
Details	binding site for residue BU3 B 301

Chain	Residue
A	HIS173
B	SER87
B	TRP88
B	GLU91
G	ALA212
G	HIS218

---

site_id	AD5
Number of Residues	35
Details	binding site for residue FAD B 302

Chain	Residue
B	ILE32
B	ALA33
B	THR34
B	VAL51
B	ALA52
B	ALA75
B	ARG76
B	GLY77
B	THR78
B	ARG79
B	ASN81
B	SER83
B	THR104
B	GLN109
B	LEU136
B	PHE137
B	CYS138
B	MET139
B	GLU140
B	ASN141
B	TYR203
B	GLY213
B	SER214
B	VAL215
B	HOH428
B	HOH433
B	HOH461
B	HOH484
B	HOH485
B	HOH487
B	ALA27
B	GLN28
B	ASP29
B	GLY30
B	GLY31

---

site_id	AD6
Number of Residues	12
Details	binding site for residue SF4 B 303

Chain	Residue
B	CYS107
B	CYS108
B	CYS138
B	MET139
B	GLU140
B	ASN141
B	CYS197
B	CYS200
B	LYS266
B	HOH511
G	MET206
G	ARG246

---

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CmGCGtCAaSCP

Chain	Residue	Details
G	CYS205-PRO216
G	CYS234-PRO245

---

site_id	PS00507
Number of Residues	26
Details	NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGIEklaigktmeqvpkiaSRvCGIC

Chain	Residue	Details
A	ARG41-CYS66

---

site_id	PS00508
Number of Residues	10
Details	NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. YDPCVSCat.H

Chain	Residue	Details
A	TYR429-HIS438

---