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6QGS

Crystal structure of APT1 bound to palmitic acid.

Functional Information from GO Data
ChainGOidnamespacecontents
A0002084biological_processprotein depalmitoylation
A0004620molecular_functionphospholipase activity
A0004622molecular_functionlysophospholipase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006631biological_processfatty acid metabolic process
A0008474molecular_functionpalmitoyl-(protein) hydrolase activity
A0015908biological_processfatty acid transport
A0016298molecular_functionlipase activity
A0016787molecular_functionhydrolase activity
A0031965cellular_componentnuclear membrane
A0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
A0052689molecular_functioncarboxylic ester hydrolase activity
A0070062cellular_componentextracellular exosome
A1905336biological_processnegative regulation of aggrephagy
B0002084biological_processprotein depalmitoylation
B0004620molecular_functionphospholipase activity
B0004622molecular_functionlysophospholipase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006631biological_processfatty acid metabolic process
B0008474molecular_functionpalmitoyl-(protein) hydrolase activity
B0015908biological_processfatty acid transport
B0016298molecular_functionlipase activity
B0016787molecular_functionhydrolase activity
B0031965cellular_componentnuclear membrane
B0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
B0052689molecular_functioncarboxylic ester hydrolase activity
B0070062cellular_componentextracellular exosome
B1905336biological_processnegative regulation of aggrephagy
C0002084biological_processprotein depalmitoylation
C0004620molecular_functionphospholipase activity
C0004622molecular_functionlysophospholipase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006631biological_processfatty acid metabolic process
C0008474molecular_functionpalmitoyl-(protein) hydrolase activity
C0015908biological_processfatty acid transport
C0016298molecular_functionlipase activity
C0016787molecular_functionhydrolase activity
C0031965cellular_componentnuclear membrane
C0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
C0052689molecular_functioncarboxylic ester hydrolase activity
C0070062cellular_componentextracellular exosome
C1905336biological_processnegative regulation of aggrephagy
D0002084biological_processprotein depalmitoylation
D0004620molecular_functionphospholipase activity
D0004622molecular_functionlysophospholipase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006631biological_processfatty acid metabolic process
D0008474molecular_functionpalmitoyl-(protein) hydrolase activity
D0015908biological_processfatty acid transport
D0016298molecular_functionlipase activity
D0016787molecular_functionhydrolase activity
D0031965cellular_componentnuclear membrane
D0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
D0052689molecular_functioncarboxylic ester hydrolase activity
D0070062cellular_componentextracellular exosome
D1905336biological_processnegative regulation of aggrephagy
E0002084biological_processprotein depalmitoylation
E0004620molecular_functionphospholipase activity
E0004622molecular_functionlysophospholipase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006631biological_processfatty acid metabolic process
E0008474molecular_functionpalmitoyl-(protein) hydrolase activity
E0015908biological_processfatty acid transport
E0016298molecular_functionlipase activity
E0016787molecular_functionhydrolase activity
E0031965cellular_componentnuclear membrane
E0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
E0052689molecular_functioncarboxylic ester hydrolase activity
E0070062cellular_componentextracellular exosome
E1905336biological_processnegative regulation of aggrephagy
F0002084biological_processprotein depalmitoylation
F0004620molecular_functionphospholipase activity
F0004622molecular_functionlysophospholipase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006631biological_processfatty acid metabolic process
F0008474molecular_functionpalmitoyl-(protein) hydrolase activity
F0015908biological_processfatty acid transport
F0016298molecular_functionlipase activity
F0016787molecular_functionhydrolase activity
F0031965cellular_componentnuclear membrane
F0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
F0052689molecular_functioncarboxylic ester hydrolase activity
F0070062cellular_componentextracellular exosome
F1905336biological_processnegative regulation of aggrephagy
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue PLM D 400
ChainResidue
DLEU30
DLEU78
DSER119
DGLN120
DTRP145
DLEU184
DHIS208
EASN64

site_idAC2
Number of Residues11
Detailsbinding site for residue PLM A 301
ChainResidue
AGLY77
ASER79
ASER119
AGLN120
ATRP145
AARG149
AVAL177
APHE181
ALEU184
ATHR185
ALEU30

site_idAC3
Number of Residues1
Detailsbinding site for residue CL A 302
ChainResidue
AALA16

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:19439193, ECO:0000269|PubMed:37802024
ChainResidueDetails
BSER119
DSER119
ASER119
CSER119
ESER119
FSER119

site_idSWS_FT_FI2
Number of Residues12
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:11080636
ChainResidueDetails
BASP174
EHIS208
FASP174
FHIS208
BHIS208
DASP174
DHIS208
AASP174
AHIS208
CASP174
CHIS208
EASP174

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P97823
ChainResidueDetails
BLYS224
DLYS224
ALYS224
CLYS224
ELYS224
FLYS224

224201

PDB entries from 2024-08-28

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