6QG4

Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine inhibitor 1h

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue J0E A 501

Chain	Residue
A	MET142
A	HOH601
A	LYS165
A	ASP182
A	MET212
A	GLU213
A	MET215
A	CYS218
A	LYS221
A	SER263

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDVKpsNILL

Chain	Residue	Details
A	VAL255-LEU267

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	GLY216

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAP3K => ECO:0000250

Chain	Residue	Details
A	LYS244

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAP3K => ECO:0000250

Chain	Residue	Details
A	TYR248

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ARG384

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