Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QG2

Structure of eIF2B-eIF2 (phosphorylated at Ser51) complex (model A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006417	biological_process	regulation of translation
A	0006446	biological_process	regulation of translational initiation
A	0030234	molecular_function	enzyme regulator activity
A	0032045	cellular_component	guanyl-nucleotide exchange factor complex
A	0045948	biological_process	positive regulation of translational initiation
A	1900036	biological_process	positive regulation of cellular response to heat
A	1903833	biological_process	positive regulation of cellular response to amino acid starvation
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0006417	biological_process	regulation of translation
B	0006446	biological_process	regulation of translational initiation
B	0030234	molecular_function	enzyme regulator activity
B	0032045	cellular_component	guanyl-nucleotide exchange factor complex
B	0045948	biological_process	positive regulation of translational initiation
B	1900036	biological_process	positive regulation of cellular response to heat
B	1903833	biological_process	positive regulation of cellular response to amino acid starvation
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006417	biological_process	regulation of translation
C	0006446	biological_process	regulation of translational initiation
C	0030234	molecular_function	enzyme regulator activity
C	0032045	cellular_component	guanyl-nucleotide exchange factor complex
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006417	biological_process	regulation of translation
D	0006446	biological_process	regulation of translational initiation
D	0030234	molecular_function	enzyme regulator activity
D	0032045	cellular_component	guanyl-nucleotide exchange factor complex
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0006417	biological_process	regulation of translation
E	0006446	biological_process	regulation of translational initiation
E	0032045	cellular_component	guanyl-nucleotide exchange factor complex
E	1903574	biological_process	negative regulation of cellular response to amino acid starvation
F	0002183	biological_process	cytoplasmic translational initiation
F	0003743	molecular_function	translation initiation factor activity
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0006417	biological_process	regulation of translation
F	0006446	biological_process	regulation of translational initiation
F	0032045	cellular_component	guanyl-nucleotide exchange factor complex
F	1903574	biological_process	negative regulation of cellular response to amino acid starvation
G	0002183	biological_process	cytoplasmic translational initiation
G	0003743	molecular_function	translation initiation factor activity
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
G	0006417	biological_process	regulation of translation
G	0006446	biological_process	regulation of translational initiation
G	0030234	molecular_function	enzyme regulator activity
G	0032045	cellular_component	guanyl-nucleotide exchange factor complex
H	0002183	biological_process	cytoplasmic translational initiation
H	0003743	molecular_function	translation initiation factor activity
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
H	0006417	biological_process	regulation of translation
H	0006446	biological_process	regulation of translational initiation
H	0030234	molecular_function	enzyme regulator activity
H	0032045	cellular_component	guanyl-nucleotide exchange factor complex
I	0002183	biological_process	cytoplasmic translational initiation
I	0003743	molecular_function	translation initiation factor activity
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
I	0006417	biological_process	regulation of translation
I	0006446	biological_process	regulation of translational initiation
I	0009058	biological_process	biosynthetic process
I	0031369	molecular_function	translation initiation factor binding
I	0032045	cellular_component	guanyl-nucleotide exchange factor complex
J	0002183	biological_process	cytoplasmic translational initiation
J	0003743	molecular_function	translation initiation factor activity
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
J	0006412	biological_process	translation
J	0006413	biological_process	translational initiation
J	0006417	biological_process	regulation of translation
J	0006446	biological_process	regulation of translational initiation
J	0009058	biological_process	biosynthetic process
J	0031369	molecular_function	translation initiation factor binding
J	0032045	cellular_component	guanyl-nucleotide exchange factor complex
K	0001731	biological_process	formation of translation preinitiation complex
K	0003676	molecular_function	nucleic acid binding
K	0003723	molecular_function	RNA binding
K	0003743	molecular_function	translation initiation factor activity
K	0005515	molecular_function	protein binding
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
K	0006412	biological_process	translation
K	0006413	biological_process	translational initiation
K	0010494	cellular_component	cytoplasmic stress granule
K	0033290	cellular_component	eukaryotic 48S preinitiation complex
K	0043022	molecular_function	ribosome binding
K	0043614	cellular_component	multi-eIF complex
K	1990856	molecular_function	methionyl-initiator methionine tRNA binding
L	0001731	biological_process	formation of translation preinitiation complex
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0003743	molecular_function	translation initiation factor activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
L	0006412	biological_process	translation
L	0006413	biological_process	translational initiation
L	0010494	cellular_component	cytoplasmic stress granule
L	0033290	cellular_component	eukaryotic 48S preinitiation complex
L	0043022	molecular_function	ribosome binding
L	0043614	cellular_component	multi-eIF complex
L	1990856	molecular_function	methionyl-initiator methionine tRNA binding
M	0000049	molecular_function	tRNA binding
M	0000166	molecular_function	nucleotide binding
M	0001731	biological_process	formation of translation preinitiation complex
M	0003743	molecular_function	translation initiation factor activity
M	0003924	molecular_function	GTPase activity
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
M	0006412	biological_process	translation
M	0006413	biological_process	translational initiation
M	0016282	cellular_component	eukaryotic 43S preinitiation complex
M	0016787	molecular_function	hydrolase activity
M	0031369	molecular_function	translation initiation factor binding
M	0033290	cellular_component	eukaryotic 48S preinitiation complex
M	0043614	cellular_component	multi-eIF complex
M	0045903	biological_process	positive regulation of translational fidelity
M	1990856	molecular_function	methionyl-initiator methionine tRNA binding
N	0000049	molecular_function	tRNA binding
N	0000166	molecular_function	nucleotide binding
N	0001731	biological_process	formation of translation preinitiation complex
N	0003743	molecular_function	translation initiation factor activity
N	0003924	molecular_function	GTPase activity
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
N	0006412	biological_process	translation
N	0006413	biological_process	translational initiation
N	0016282	cellular_component	eukaryotic 43S preinitiation complex
N	0016787	molecular_function	hydrolase activity
N	0031369	molecular_function	translation initiation factor binding
N	0033290	cellular_component	eukaryotic 48S preinitiation complex
N	0043614	cellular_component	multi-eIF complex
N	0045903	biological_process	positive regulation of translational fidelity
N	1990856	molecular_function	methionyl-initiator methionine tRNA binding
O	0001731	biological_process	formation of translation preinitiation complex
O	0003729	molecular_function	mRNA binding
O	0003743	molecular_function	translation initiation factor activity
O	0005515	molecular_function	protein binding
O	0005525	molecular_function	GTP binding
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
O	0006412	biological_process	translation
O	0006413	biological_process	translational initiation
O	0008270	molecular_function	zinc ion binding
O	0016282	cellular_component	eukaryotic 43S preinitiation complex
O	0031369	molecular_function	translation initiation factor binding
O	0043614	cellular_component	multi-eIF complex
O	0046872	molecular_function	metal ion binding
O	1990856	molecular_function	methionyl-initiator methionine tRNA binding
P	0001731	biological_process	formation of translation preinitiation complex
P	0003729	molecular_function	mRNA binding
P	0003743	molecular_function	translation initiation factor activity
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
P	0006412	biological_process	translation
P	0006413	biological_process	translational initiation
P	0008270	molecular_function	zinc ion binding
P	0016282	cellular_component	eukaryotic 43S preinitiation complex
P	0031369	molecular_function	translation initiation factor binding
P	0043614	cellular_component	multi-eIF complex
P	0046872	molecular_function	metal ion binding
P	1990856	molecular_function	methionyl-initiator methionine tRNA binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by GCN2","evidences":[{"source":"PubMed","id":"10733573","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1739968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8336737","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	14
Details	Region: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Region: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Region: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Region: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Region: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30475211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)