6QEN
Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the 3-Oxo-beta-Sultam inhibitor LMC240
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue J05 A 1001 |
| Chain | Residue |
| A | THR41 |
| A | SER195 |
| A | SER214 |
| A | PHE215 |
| A | HOH1186 |
| A | HOH1200 |
| A | HIS57 |
| A | CYS58 |
| A | ARG61 |
| A | LEU63 |
| A | CYS191 |
| A | GLN192 |
| A | GLY193 |
| A | ASP194 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 1002 |
| Chain | Residue |
| A | GLY127 |
| A | ARG145 |
| A | ARG230 |
| A | SER232 |
| A | ALA233 |
| A | HOH1107 |
| A | HOH1113 |
| A | HOH1166 |
| A | HOH1226 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 1003 |
| Chain | Residue |
| A | TYR137 |
| A | GLN156 |
| A | TYR207 |
| A | HOH1103 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue MPD A 1004 |
| Chain | Residue |
| A | GLU62 |
| A | VAL99 |
| A | PHE215 |
| A | VAL216 |
| A | HOH1152 |
| A | HOH1217 |
| A | HOH1237 |
| A | HOH1240 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 1005 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | GLN75 |
| A | GLU80 |
| A | HOH1102 |
| A | HOH1105 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 237 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"4578945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7656008","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ELA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
