6QD2

MloK1 model from single particle analysis of 2D crystals, class 6 (intermediate compact conformation)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
A	0005267	molecular_function	potassium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0030552	molecular_function	cAMP binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
B	0005267	molecular_function	potassium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0030552	molecular_function	cAMP binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
C	0005267	molecular_function	potassium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0030552	molecular_function	cAMP binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
D	0005267	molecular_function	potassium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0030552	molecular_function	cAMP binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue K A 401

Chain	Residue
A	GLY177
A	TYR178
B	GLY177
B	TYR178
C	GLY177
C	TYR178
D	GLY177
D	TYR178

---

site_id	AC2
Number of Residues	8
Details	binding site for residue K A 402

Chain	Residue
A	THR176
B	THR175
B	THR176
C	THR175
C	THR176
D	THR175
D	THR176
A	THR175

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrIGEpGDrMFFVveG

Chain	Residue	Details
A	ILE262-GLY278

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALisgep......RSAtVsA

Chain	Residue	Details
A	PHE296-ALA313

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	732
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
A	MET1-PRO12
C	LYS62-LYS74
C	THR113-LEU129
C	ALA211-ALA355
D	MET1-PRO12
D	LYS62-LYS74
D	THR113-LEU129
D	ALA211-ALA355
A	LYS62-LYS74
A	THR113-LEU129
A	ALA211-ALA355
B	MET1-PRO12
B	LYS62-LYS74
B	THR113-LEU129
B	ALA211-ALA355
C	MET1-PRO12

---

site_id	SWS_FT_FI2
Number of Residues	68
Details	TRANSMEM: Helical; Name=Segment S1

Chain	Residue	Details
A	LEU13-ILE30
B	LEU13-ILE30
C	LEU13-ILE30
D	LEU13-ILE30

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	TOPO_DOM: Periplasmic

Chain	Residue	Details
A	PRO31-ARG38
D	PRO31-ARG38
D	GLU151-SER161
D	THR181-SER185
A	GLU151-SER161
A	THR181-SER185
B	PRO31-ARG38
B	GLU151-SER161
B	THR181-SER185
C	PRO31-ARG38
C	GLU151-SER161
C	THR181-SER185

---

site_id	SWS_FT_FI4
Number of Residues	88
Details	TRANSMEM: Helical; Name=Segment S2

Chain	Residue	Details
A	LEU39-LEU61
B	LEU39-LEU61
C	LEU39-LEU61
D	LEU39-LEU61

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	TRANSMEM: Helical; Name=Segment S3

Chain	Residue	Details
A	ILE75-SER94
B	ILE75-SER94
C	ILE75-SER94
D	ILE75-SER94

---

site_id	SWS_FT_FI6
Number of Residues	68
Details	TRANSMEM: Helical; Name=Segment S4

Chain	Residue	Details
A	PRO95-SER112
B	PRO95-SER112
C	PRO95-SER112
D	PRO95-SER112

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	TRANSMEM: Helical; Name=Segment S5

Chain	Residue	Details
A	ILE130-ILE150
B	ILE130-ILE150
C	ILE130-ILE150
D	ILE130-ILE150

---

site_id	SWS_FT_FI8
Number of Residues	72
Details	INTRAMEM: Pore-forming

Chain	Residue	Details
A	ILE162-ASP180
B	ILE162-ASP180
C	ILE162-ASP180
D	ILE162-ASP180

---

site_id	SWS_FT_FI9
Number of Residues	96
Details	TRANSMEM: Helical; Name=Segment S6

Chain	Residue	Details
A	PHE186-LEU210
B	PHE186-LEU210
C	PHE186-LEU210
D	PHE186-LEU210

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744|PDB:1VP6

Chain	Residue	Details
A	GLY297
D	GLY297
D	ARG307
D	ARG348
A	ARG307
A	ARG348
B	GLY297
B	ARG307
B	ARG348
C	GLY297
C	ARG307
C	ARG348

---