6QCV

Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004519	molecular_function	endonuclease activity
A	0006351	biological_process	DNA-templated transcription
A	0030430	cellular_component	host cell cytoplasm
A	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
A	0039694	biological_process	viral RNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0046872	molecular_function	metal ion binding
A	0075526	biological_process	cap snatching
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-dependent RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
B	0039694	biological_process	viral RNA genome replication
B	0042025	cellular_component	host cell nucleus
B	0046872	molecular_function	metal ion binding
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-dependent RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0006370	biological_process	7-methylguanosine mRNA capping
C	0019083	biological_process	viral transcription
C	0033650	cellular_component	host cell mitochondrion
C	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
C	0039694	biological_process	viral RNA genome replication
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0075526	biological_process	cap snatching

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PO4 A 801

Chain	Residue
A	THR412
A	LYS631
A	ARG634

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site_id	AC2
Number of Residues	12
Details	binding site for residue CTP B 801

Chain	Residue
B	MET410
B	GLY411
B	ASP444
B	MG802
M	G14
R	G16
B	ARG239
B	ASN306
B	THR307
B	LYS308
B	TRP309
B	ASN310

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site_id	AC3
Number of Residues	4
Details	binding site for residue MG B 802

Chain	Residue
B	ASP305
B	ASN306
B	ASP444
B	CTP801

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