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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QAR

Thermolysine under 2 kbar of argon

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue GOL A 501

Chain	Residue
A	THR48
A	TRP115
A	ASP150
A	HOH1139

site_id	AC2
Number of Residues	3
Details	binding site for residue DMS A 502

Chain	Residue
A	HIS216
A	SER218
A	TYR251

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 503

Chain	Residue
A	ASP185
A	GLU187
A	GLU190
A	HOH1161
A	ASP138
A	GLU177

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 504

Chain	Residue
A	GLU177
A	ASN183
A	ASP185
A	GLU190
A	HOH1116
A	HOH1179

site_id	AC5
Number of Residues	6
Details	binding site for residue CA A 505

Chain	Residue
A	ASP57
A	ASP59
A	GLN61
A	HOH1142
A	HOH1166
A	HOH1266

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 506

Chain	Residue
A	TYR193
A	THR194
A	ILE197
A	ASP200
A	HOH1145
A	HOH1236

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 507

Chain	Residue
A	HIS142
A	HIS146
A	GLU166
A	CL531

site_id	AC8
Number of Residues	3
Details	binding site for residue AR A 508

Chain	Residue
A	TYR84
A	SER92
A	TYR93

site_id	AC9
Number of Residues	4
Details	binding site for residue AR A 509

Chain	Residue
A	ARG35
A	GLY38
A	TYR81
A	ALA98

site_id	AD1
Number of Residues	4
Details	binding site for residue AR A 510

Chain	Residue
A	GLU160
A	ARG220
A	ASN233
A	PHE281

site_id	AD2
Number of Residues	4
Details	binding site for residue AR A 511

Chain	Residue
A	ASP57
A	ALA58
A	AR527
A	HOH1266

site_id	AD3
Number of Residues	3
Details	binding site for residue AR A 512

Chain	Residue
A	TYR27
A	PRO214
A	AR527

site_id	AD4
Number of Residues	4
Details	binding site for residue AR A 513

Chain	Residue
A	ASP191
A	VAL192
A	TYR193
A	PRO195

site_id	AD5
Number of Residues	3
Details	binding site for residue AR A 514

Chain	Residue
A	GLY259
A	ARG260
A	HOH1249

site_id	AD6
Number of Residues	5
Details	binding site for residue AR A 515

Chain	Residue
A	THR249
A	TYR251
A	GLY252
A	HOH1140
A	HOH1156

site_id	AD7
Number of Residues	1
Details	binding site for residue AR A 516

Chain	Residue
A	ASN19

site_id	AD8
Number of Residues	3
Details	binding site for residue AR A 517

Chain	Residue
A	LYS85
A	ASN97
A	HOH1247

site_id	AD9
Number of Residues	1
Details	binding site for residue AR A 518

Chain	Residue
A	SER5

site_id	AE1
Number of Residues	3
Details	binding site for residue AR A 519

Chain	Residue
A	GLN108
A	PRO277
A	THR278

site_id	AE2
Number of Residues	2
Details	binding site for residue AR A 520

Chain	Residue
A	SER254
A	GLN308

site_id	AE3
Number of Residues	5
Details	binding site for residue AR A 521

Chain	Residue
A	LYS45
A	SER53
A	LYS219
A	HOH1175
A	HOH1265

site_id	AE4
Number of Residues	1
Details	binding site for residue AR A 522

Chain	Residue
A	PRO132

site_id	AE5
Number of Residues	4
Details	binding site for residue AR A 523

Chain	Residue
A	ILE168
A	ILE237
A	PHE267
A	AR526

site_id	AE6
Number of Residues	2
Details	binding site for residue AR A 524

Chain	Residue
A	GLN301
A	HOH1250

site_id	AE7
Number of Residues	3
Details	binding site for residue AR A 525

Chain	Residue
A	TYR84
A	PHE172
A	LEU271

site_id	AE8
Number of Residues	4
Details	binding site for residue AR A 526

Chain	Residue
A	ILE168
A	PHE267
A	LEU275
A	AR523

site_id	AE9
Number of Residues	4
Details	binding site for residue AR A 527

Chain	Residue
A	ALA56
A	LYS219
A	AR511
A	AR512

site_id	AF1
Number of Residues	5
Details	binding site for residue CL A 528

Chain	Residue
A	LEU14
A	GLY15
A	ASP16
A	LYS18
A	GLY12

site_id	AF2
Number of Residues	1
Details	binding site for residue CL A 529

Chain	Residue
A	ARG285

site_id	AF3
Number of Residues	7
Details	binding site for residue CL A 531

Chain	Residue
A	HIS142
A	HIS146
A	TYR157
A	GLU166
A	HIS231
A	ZN507
A	VAL537

site_id	AF4
Number of Residues	2
Details	binding site for residue CL A 532

Chain	Residue
A	ASN37
A	ALA99

site_id	AF5
Number of Residues	2
Details	binding site for residue CL A 533

Chain	Residue
A	GLN225
A	ASP226

site_id	AF6
Number of Residues	1
Details	binding site for residue CL A 535

Chain	Residue
A	SER65

site_id	AF7
Number of Residues	3
Details	binding site for residue CL A 536

Chain	Residue
A	TYR211
A	HOH1127
A	HOH1198

site_id	AF8
Number of Residues	7
Details	binding site for residue VAL A 537

Chain	Residue
A	ASN112
A	ALA113
A	GLU143
A	ARG203
A	HIS231
A	CL531
A	LYS538

site_id	AF9
Number of Residues	8
Details	binding site for residue LYS A 538

Chain	Residue
A	ASN111
A	ASN112
A	HIS231
A	VAL537
A	HOH1148
A	HOH1193
A	HOH1208
A	HOH1233

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
A	VAL139-VAL148

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255\|PROSITE-ProRule:PRU10095, ECO:0000269\|PubMed:4808703

Chain	Residue	Details
A	GLU143

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255\|PROSITE-ProRule:PRU10095, ECO:0000269\|PubMed:4808703

Chain	Residue	Details
A	HIS231

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
A	ASP57
A	ASP185
A	GLU187
A	GLU190
A	TYR193
A	THR194
A	ILE197
A	ASP200
A	ASP59
A	GLN61
A	ASP138
A	HIS142
A	HIS146
A	GLU166
A	GLU177
A	ASN183

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 176

Chain	Residue	Details
A	HIS142	metal ligand
A	GLU143	electrostatic stabiliser, metal ligand
A	HIS146	metal ligand
A	TYR157	electrostatic stabiliser, hydrogen bond donor, steric role
A	GLU166	metal ligand
A	ASP226	activator, electrostatic stabiliser, hydrogen bond acceptor
A	HIS231	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

237735

PDB entries from 2025-06-18

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