Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QAK

Structure of human ALDH9 in P21212 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006081	biological_process	cellular aldehyde metabolic process
A	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018467	molecular_function	formaldehyde dehydrogenase activity
A	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
A	0033737	molecular_function	1-pyrroline dehydrogenase activity
A	0036094	molecular_function	small molecule binding
A	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
A	0045329	biological_process	carnitine biosynthetic process
A	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
A	0051289	biological_process	protein homotetramerization
A	0070062	cellular_component	extracellular exosome
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006081	biological_process	cellular aldehyde metabolic process
B	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018467	molecular_function	formaldehyde dehydrogenase activity
B	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
B	0033737	molecular_function	1-pyrroline dehydrogenase activity
B	0036094	molecular_function	small molecule binding
B	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
B	0045329	biological_process	carnitine biosynthetic process
B	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
B	0051289	biological_process	protein homotetramerization
B	0070062	cellular_component	extracellular exosome
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006081	biological_process	cellular aldehyde metabolic process
C	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018467	molecular_function	formaldehyde dehydrogenase activity
C	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
C	0033737	molecular_function	1-pyrroline dehydrogenase activity
C	0036094	molecular_function	small molecule binding
C	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
C	0045329	biological_process	carnitine biosynthetic process
C	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
C	0051289	biological_process	protein homotetramerization
C	0070062	cellular_component	extracellular exosome
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006081	biological_process	cellular aldehyde metabolic process
D	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018467	molecular_function	formaldehyde dehydrogenase activity
D	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
D	0033737	molecular_function	1-pyrroline dehydrogenase activity
D	0036094	molecular_function	small molecule binding
D	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
D	0045329	biological_process	carnitine biosynthetic process
D	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
D	0051289	biological_process	protein homotetramerization
D	0070062	cellular_component	extracellular exosome
E	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006081	biological_process	cellular aldehyde metabolic process
E	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0018467	molecular_function	formaldehyde dehydrogenase activity
E	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
E	0033737	molecular_function	1-pyrroline dehydrogenase activity
E	0036094	molecular_function	small molecule binding
E	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
E	0045329	biological_process	carnitine biosynthetic process
E	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
E	0051289	biological_process	protein homotetramerization
E	0070062	cellular_component	extracellular exosome
F	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006081	biological_process	cellular aldehyde metabolic process
F	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0018467	molecular_function	formaldehyde dehydrogenase activity
F	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
F	0033737	molecular_function	1-pyrroline dehydrogenase activity
F	0036094	molecular_function	small molecule binding
F	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
F	0045329	biological_process	carnitine biosynthetic process
F	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
F	0051289	biological_process	protein homotetramerization
F	0070062	cellular_component	extracellular exosome
G	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006081	biological_process	cellular aldehyde metabolic process
G	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0018467	molecular_function	formaldehyde dehydrogenase activity
G	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
G	0033737	molecular_function	1-pyrroline dehydrogenase activity
G	0036094	molecular_function	small molecule binding
G	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
G	0045329	biological_process	carnitine biosynthetic process
G	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
G	0051289	biological_process	protein homotetramerization
G	0070062	cellular_component	extracellular exosome
H	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006081	biological_process	cellular aldehyde metabolic process
H	0008802	molecular_function	betaine-aldehyde dehydrogenase activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0018467	molecular_function	formaldehyde dehydrogenase activity
H	0019145	molecular_function	aminobutyraldehyde dehydrogenase activity
H	0033737	molecular_function	1-pyrroline dehydrogenase activity
H	0036094	molecular_function	small molecule binding
H	0043878	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
H	0045329	biological_process	carnitine biosynthetic process
H	0047105	molecular_function	4-trimethylammoniobutyraldehyde dehydrogenase activity
H	0051289	biological_process	protein homotetramerization
H	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue EDO B 501

Chain	Residue
B	GLN217

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FlTQGQVCCNGT

Chain	Residue	Details
A	PHE281-THR292

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU253-PRO260

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	GLU254
B	GLU254
C	GLU254
D	GLU254
E	GLU254
F	GLU254
G	GLU254
H	GLU254

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000255\|PROSITE-ProRule:PRU10007, ECO:0000255\|PROSITE-ProRule:PRU10008

Chain	Residue	Details
A	CYS288
B	CYS288
C	CYS288
D	CYS288
E	CYS288
F	CYS288
G	CYS288
H	CYS288

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P56533

Chain	Residue	Details
A	LYS180
D	LYS180
D	GLY232
D	GLU391
E	LYS180
E	GLY232
E	GLU391
F	LYS180
F	GLY232
F	GLU391
G	LYS180
A	GLY232
G	GLY232
G	GLU391
H	LYS180
H	GLY232
H	GLU391
A	GLU391
B	LYS180
B	GLY232
B	GLU391
C	LYS180
C	GLY232
C	GLU391

site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	ASN157
B	ASN157
C	ASN157
D	ASN157
E	ASN157
F	ASN157
G	ASN157
H	ASN157

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N-acetylserine; in 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed => ECO:0000269\|Ref.7, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2
E	SER2
F	SER2
G	SER2
H	SER2

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q9JLJ2

Chain	Residue	Details
A	LYS30
E	LYS303
F	LYS30
F	LYS303
G	LYS30
G	LYS303
H	LYS30
H	LYS303
A	LYS303
B	LYS30
B	LYS303
C	LYS30
C	LYS303
D	LYS30
D	LYS303
E	LYS30

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:Q9JLJ2

Chain	Residue	Details
A	LYS59
B	LYS59
C	LYS59
D	LYS59
E	LYS59
F	LYS59
G	LYS59
H	LYS59

site_id	SWS_FT_FI8
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS298
B	LYS298
C	LYS298
D	LYS298
E	LYS298
F	LYS298
G	LYS298
H	LYS298

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9JLJ2

Chain	Residue	Details
A	LYS344
B	LYS344
C	LYS344
D	LYS344
E	LYS344
F	LYS344
G	LYS344
H	LYS344

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)