6QA2

R80A MUTANT OF NUCLEOSIDE DIPHOSPHATE KINASE FROM MYCOBACTERIUM TUBERCULOSIS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001907	biological_process	symbiont-mediated killing of host cell
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006163	biological_process	purine nucleotide metabolic process
A	0006183	biological_process	GTP biosynthetic process
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
B	0000166	molecular_function	nucleotide binding
B	0001907	biological_process	symbiont-mediated killing of host cell
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004844	molecular_function	uracil DNA N-glycosylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006163	biological_process	purine nucleotide metabolic process
B	0006183	biological_process	GTP biosynthetic process
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
C	0000166	molecular_function	nucleotide binding
C	0001907	biological_process	symbiont-mediated killing of host cell
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0004721	molecular_function	phosphoprotein phosphatase activity
C	0004844	molecular_function	uracil DNA N-glycosylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006163	biological_process	purine nucleotide metabolic process
C	0006183	biological_process	GTP biosynthetic process
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
D	0000166	molecular_function	nucleotide binding
D	0001907	biological_process	symbiont-mediated killing of host cell
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004844	molecular_function	uracil DNA N-glycosylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006163	biological_process	purine nucleotide metabolic process
D	0006183	biological_process	GTP biosynthetic process
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006228	biological_process	UTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0009117	biological_process	nucleotide metabolic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
E	0000166	molecular_function	nucleotide binding
E	0001907	biological_process	symbiont-mediated killing of host cell
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0004844	molecular_function	uracil DNA N-glycosylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006163	biological_process	purine nucleotide metabolic process
E	0006183	biological_process	GTP biosynthetic process
E	0006220	biological_process	pyrimidine nucleotide metabolic process
E	0006228	biological_process	UTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0009117	biological_process	nucleotide metabolic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction
F	0000166	molecular_function	nucleotide binding
F	0001907	biological_process	symbiont-mediated killing of host cell
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0004721	molecular_function	phosphoprotein phosphatase activity
F	0004844	molecular_function	uracil DNA N-glycosylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006163	biological_process	purine nucleotide metabolic process
F	0006183	biological_process	GTP biosynthetic process
F	0006220	biological_process	pyrimidine nucleotide metabolic process
F	0006228	biological_process	UTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0009117	biological_process	nucleotide metabolic process
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0046872	molecular_function	metal ion binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0141127	biological_process	symbiont-mediated perturbation of host Rab small GTPase signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 200

Chain	Residue
A	ARG86
A	THR92
A	ARG104
A	HIS117
A	HOH320

---

site_id	AC2
Number of Residues	1
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG86

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 B 201

Chain	Residue
B	HIS117
B	ARG86
B	THR92
B	ARG104

---

site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 B 202

Chain	Residue
B	ARG86

---

site_id	AC5
Number of Residues	9
Details	binding site for residue TAM B 203

Chain	Residue
B	GLU21
B	ARG25
B	ARG28
D	GLU21
D	ARG25
D	ARG28
F	GLU21
F	ARG25
F	ARG28

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 C 201

Chain	Residue
C	ARG86
C	THR92
C	ARG104
C	HIS117
C	HOH302
C	HOH340

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 C 202

Chain	Residue
C	ARG86
C	HOH312

---

site_id	AC8
Number of Residues	10
Details	binding site for residue TAM C 203

Chain	Residue
A	GLU21
A	ARG25
A	ARG28
C	GLU21
C	ARG25
C	ARG28
C	HOH308
E	GLU21
E	ARG25
E	ARG28

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 D 200

Chain	Residue
D	ARG86
D	THR92
D	ARG104
D	HIS117

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 D 201

Chain	Residue
D	ARG86
D	HOH304
D	HOH354

---

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 E 200

Chain	Residue
E	ARG86
E	THR92
E	ARG104
E	HIS117
E	HOH301
E	HOH308
E	HOH320
E	HOH331

---

site_id	AD3
Number of Residues	1
Details	binding site for residue SO4 E 201

Chain	Residue
E	ARG86

---

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 F 200

Chain	Residue
F	ARG86
F	THR92
F	ARG104
F	HIS117
F	HOH302
F	HOH316
F	HOH334

---

site_id	AD5
Number of Residues	1
Details	binding site for residue SO4 F 201

Chain	Residue
F	ARG86

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00451","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---