Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q9T

Protein-aromatic foldamer complex crystal structure

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004064	molecular_function	arylesterase activity
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0015670	biological_process	carbon dioxide transport
A	0016829	molecular_function	lyase activity
A	0018820	molecular_function	cyanamide hydratase activity
A	0038166	biological_process	angiotensin-activated signaling pathway
A	0044070	biological_process	regulation of monoatomic anion transport
A	0045177	cellular_component	apical part of cell
A	0046872	molecular_function	metal ion binding
A	0051453	biological_process	regulation of intracellular pH
A	0070062	cellular_component	extracellular exosome
A	2001150	biological_process	positive regulation of dipeptide transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS94
A	HIS96
A	HIS119

site_id	AC3
Number of Residues	3
Details	binding site for residues QUJ A 303 and ZY9 A 304

Chain	Residue
B	QVS305
B	QUK306
B	ZY9307

site_id	AC4
Number of Residues	6
Details	binding site for residues ZY9 A 304 and QVS A 305

Chain	Residue
B	QUK306
B	ZY9307
B	QVE308
A	PHE20
B	QUJ303
B	QUJ303

site_id	AC5
Number of Residues	6
Details	binding site for residues QVS A 305 and QUK A 306

Chain	Residue
A	PHE20
B	QUJ303
B	ZY9304
B	ZY9307
B	QVE308
B	ZY9309

site_id	AC6
Number of Residues	8
Details	binding site for residues QUK A 306 and ZY9 A 307

Chain	Residue
A	PHE20
A	PRO201
B	QUJ303
B	ZY9304
B	QVS305
B	QVE308
B	ZY9309
B	ZY9310

site_id	AC7
Number of Residues	8
Details	binding site for residues ZY9 A 307 and QVE A 308

Chain	Residue
A	PHE20
A	PRO201
B	ZY9304
B	QVS305
B	QUK306
B	ZY9309
B	ZY9310
B	QVS311

site_id	AC8
Number of Residues	7
Details	binding site for residues QVE A 308 and ZY9 A 309

Chain	Residue
A	GLN135
B	QVS305
B	QUK306
B	ZY9307
B	ZY9310
B	QVS311
B	ZY9312

site_id	AC9
Number of Residues	8
Details	binding site for residues ZY9 A 309 and ZY9 A 310

Chain	Residue
A	ASP19
A	GLN135
B	QUK306
B	ZY9307
B	QVE308
B	QVS311
B	ZY9312
B	QDD313

site_id	AD1
Number of Residues	8
Details	binding site for residues ZY9 A 310 and QVS A 311

Chain	Residue
A	ASP19
B	ZY9307
B	QVE308
B	ZY9309
B	ZY9312
B	QDD313
B	ZY9314
B	HOH401

site_id	AD2
Number of Residues	8
Details	binding site for residues QVS A 311 and ZY9 A 312

Chain	Residue
A	LEU203
B	QVE308
B	ZY9309
B	ZY9310
B	QDD313
B	ZY9314
B	QVE315
B	HOH401

site_id	AD3
Number of Residues	7
Details	binding site for residues ZY9 A 312 and QDD A 313

Chain	Residue
A	LEU203
B	ZY9309
B	ZY9310
B	QVS311
B	ZY9314
B	QVE315
B	QUK316

site_id	AD4
Number of Residues	5
Details	binding site for residues QDD A 313 and ZY9 A 314

Chain	Residue
B	ZY9310
B	QVS311
B	ZY9312
B	QVE315
B	QUK316

site_id	AD5
Number of Residues	10
Details	binding site for residues ZY9 A 314 and QVE A 315

Chain	Residue
A	PRO21
A	ILE22
A	SER48
A	VAL49
A	SER50
A	LYS80
B	QVS311
B	ZY9312
B	QDD313
B	QUK316

site_id	AD6
Number of Residues	13
Details	binding site for residues QVE A 315 and QUK A 316

Chain	Residue
B	HOH402
A	PRO21
A	ILE22
A	SER48
A	VAL49
A	SER50
A	LYS80
A	ARG181
A	PRO185
A	LEU188
B	ZY9312
B	QDD313
B	ZY9314

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV

Chain	Residue	Details
A	SER105-VAL121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15667203","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17330962","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11076507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12499545","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1336460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1433293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1909891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19583303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3151019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3151020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4621826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7761440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7803386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7901850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8218160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8262987","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8331673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8399159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8431430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8451242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8482389","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8639494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8987974","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9398308","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9865942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11076507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12499545","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1336460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1433293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1909891","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19583303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3151019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3151020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7761440","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7803386","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7901850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8218160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8262987","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8331673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8399159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8431430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8451242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8482389","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8639494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8987974","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9398308","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9865942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10550681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19520834","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine","evidences":[{"source":"PubMed","id":"16214338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9265618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17330962","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Involved in the binding of some activators, including histamine and L-histidine","evidences":[{"source":"PubMed","id":"16214338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9265618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17330962","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 216

Chain	Residue	Details
A	HIS64	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	HIS94	metal ligand
A	HIS96	metal ligand
A	GLU106	activator, electrostatic stabiliser, hydrogen bond acceptor
A	HIS119	metal ligand
A	THR198	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)