6Q9G
Crystal structure of reduced Aquifex aeolicus NADH-quinone oxidoreductase subunits NuoE G129D and NuoF bound to NADH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048038 | molecular_function | quinone binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| B | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048038 | molecular_function | quinone binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0003954 | molecular_function | NADH dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048038 | molecular_function | quinone binding |
| C | 0051536 | molecular_function | iron-sulfur cluster binding |
| C | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| D | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| D | 0010181 | molecular_function | FMN binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048038 | molecular_function | quinone binding |
| D | 0051536 | molecular_function | iron-sulfur cluster binding |
| D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue FES A 201 |
| Chain | Residue |
| A | CYS86 |
| A | VAL90 |
| A | CYS91 |
| A | CYS127 |
| A | LEU128 |
| A | ASP129 |
| A | ALA130 |
| A | CYS131 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ARG27 |
| A | HOH310 |
| A | LYS25 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | PHE73 |
| A | ARG75 |
| A | GLU76 |
| A | HOH321 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue SF4 B 501 |
| Chain | Residue |
| B | ILE181 |
| B | PRO199 |
| B | THR346 |
| B | CYS347 |
| B | GLY348 |
| B | GLN349 |
| B | CYS350 |
| B | CYS353 |
| B | SER391 |
| B | ILE392 |
| B | CYS393 |
| B | LEU395 |
| B | GLY396 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue FMN B 502 |
| Chain | Residue |
| B | GLY65 |
| B | ARG66 |
| B | GLY67 |
| B | LYS76 |
| B | ASN92 |
| B | ASP94 |
| B | GLU95 |
| B | GLY183 |
| B | GLU184 |
| B | GLU185 |
| B | VAL218 |
| B | ASN219 |
| B | ASN220 |
| B | THR223 |
| B | NAI503 |
| B | HOH667 |
| B | HOH683 |
| B | HOH691 |
| B | HOH716 |
| B | HOH780 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | binding site for residue NAI B 503 |
| Chain | Residue |
| B | GLY67 |
| B | GLY68 |
| B | ALA69 |
| B | PHE71 |
| B | LYS76 |
| B | GLU95 |
| B | SER96 |
| B | GLU97 |
| B | TYR180 |
| B | GLU185 |
| B | TYR205 |
| B | PRO206 |
| B | FMN502 |
| B | HOH635 |
| B | HOH655 |
| B | HOH680 |
| B | HOH696 |
| B | HOH713 |
| B | HOH742 |
| B | HOH758 |
| B | HOH789 |
| B | HOH796 |
| B | HOH820 |
| B | HOH845 |
| D | TRP235 |
| D | ARG239 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | TYR34 |
| B | ASP37 |
| B | GLY38 |
| B | GLY39 |
| B | GLU116 |
| B | PRO228 |
| B | HOH642 |
| B | HOH733 |
| B | HOH741 |
| B | HOH771 |
| B | HOH795 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 505 |
| Chain | Residue |
| B | GLU33 |
| B | HOH732 |
| B | HOH868 |
| B | HOH914 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue NA B 506 |
| Chain | Residue |
| B | GLU53 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue FES C 201 |
| Chain | Residue |
| C | CYS86 |
| C | SER88 |
| C | VAL90 |
| C | CYS91 |
| C | CYS127 |
| C | LEU128 |
| C | ASP129 |
| C | ALA130 |
| C | CYS131 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | ASP74 |
| C | ARG75 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 203 |
| Chain | Residue |
| C | LYS25 |
| C | ARG27 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue SF4 D 501 |
| Chain | Residue |
| D | ILE181 |
| D | PRO199 |
| D | THR346 |
| D | CYS347 |
| D | GLY348 |
| D | GLN349 |
| D | CYS350 |
| D | CYS353 |
| D | SER391 |
| D | ILE392 |
| D | CYS393 |
| D | LEU395 |
| D | GLY396 |
| site_id | AD5 |
| Number of Residues | 23 |
| Details | binding site for residue FMN D 502 |
| Chain | Residue |
| D | GLY65 |
| D | ARG66 |
| D | GLY67 |
| D | LYS76 |
| D | ASN92 |
| D | ASP94 |
| D | GLU95 |
| D | TYR180 |
| D | ILE181 |
| D | GLY183 |
| D | GLU184 |
| D | GLU185 |
| D | VAL218 |
| D | ASN219 |
| D | ASN220 |
| D | THR223 |
| D | GLY394 |
| D | NAI503 |
| D | HOH683 |
| D | HOH684 |
| D | HOH691 |
| D | HOH753 |
| D | HOH768 |
| site_id | AD6 |
| Number of Residues | 24 |
| Details | binding site for residue NAI D 503 |
| Chain | Residue |
| D | GLY67 |
| D | GLY68 |
| D | ALA69 |
| D | PHE71 |
| D | LYS76 |
| D | GLU95 |
| D | SER96 |
| D | GLU97 |
| D | TYR180 |
| D | GLU185 |
| D | TYR205 |
| D | PRO206 |
| D | FMN502 |
| D | HOH625 |
| D | HOH635 |
| D | HOH637 |
| D | HOH638 |
| D | HOH654 |
| D | HOH663 |
| D | HOH669 |
| D | HOH736 |
| D | HOH737 |
| D | HOH778 |
| D | HOH787 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 504 |
| Chain | Residue |
| D | TYR34 |
| D | ASP37 |
| D | GLY39 |
| D | GLU116 |
| D | PRO228 |
| D | HOH661 |
| D | HOH701 |
| D | HOH766 |
| D | HOH767 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 505 |
| Chain | Residue |
| B | LYS25 |
| B | ARG27 |
| D | LYS160 |
| D | GLU170 |
| D | HOH846 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue NA D 506 |
| Chain | Residue |
| D | PRO243 |
| D | ASP310 |
| D | HOH928 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGFGGTGTVIvLteeddive..........AALK |
| Chain | Residue | Details |
| B | LEU314-LYS337 |
| site_id | PS00644 |
| Number of Residues | 16 |
| Details | COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES |
| Chain | Residue | Details |
| B | GLY176-SER191 |
| site_id | PS00645 |
| Number of Residues | 12 |
| Details | COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ETCGqCtPCRvG |
| Chain | Residue | Details |
| B | GLU345-GLY356 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
