Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q9B

CI Membrane Arm focused refinement from Ovine respiratory SC I+III2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
4L	0005739	cellular_component	mitochondrion
4L	0005743	cellular_component	mitochondrial inner membrane
4L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4L	0030964	cellular_component	NADH dehydrogenase complex
4L	0042773	biological_process	ATP synthesis coupled electron transport
4L	0045271	cellular_component	respiratory chain complex I
4L	1902600	biological_process	proton transmembrane transport
A3	0005743	cellular_component	mitochondrial inner membrane
A3	0045271	cellular_component	respiratory chain complex I
A8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AB	0006633	biological_process	fatty acid biosynthetic process
AJ	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AK	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B1	0005739	cellular_component	mitochondrion
B1	0005743	cellular_component	mitochondrial inner membrane
B1	0016020	cellular_component	membrane
B2	0005743	cellular_component	mitochondrial inner membrane
B2	0045271	cellular_component	respiratory chain complex I
B3	0005739	cellular_component	mitochondrion
B3	0022900	biological_process	electron transport chain
B4	0005739	cellular_component	mitochondrion
B4	0005743	cellular_component	mitochondrial inner membrane
B4	0016020	cellular_component	membrane
B6	0005743	cellular_component	mitochondrial inner membrane
B6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B6	0016020	cellular_component	membrane
B6	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
B7	0005739	cellular_component	mitochondrion
B8	0005739	cellular_component	mitochondrion
B8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B9	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C1	0005739	cellular_component	mitochondrion
C1	0045271	cellular_component	respiratory chain complex I
C2	0005737	cellular_component	cytoplasm
C2	0005739	cellular_component	mitochondrion
C2	0005743	cellular_component	mitochondrial inner membrane
C2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
C2	0045271	cellular_component	respiratory chain complex I
D1	0003954	molecular_function	NADH dehydrogenase activity
D1	0005739	cellular_component	mitochondrion
D1	0005743	cellular_component	mitochondrial inner membrane
D1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D1	0009060	biological_process	aerobic respiration
D1	0016020	cellular_component	membrane
D1	0031966	cellular_component	mitochondrial membrane
D1	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D1	0045271	cellular_component	respiratory chain complex I
D1	1902600	biological_process	proton transmembrane transport
D2	0005739	cellular_component	mitochondrion
D2	0005743	cellular_component	mitochondrial inner membrane
D2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D2	0045271	cellular_component	respiratory chain complex I
D2	0072593	biological_process	reactive oxygen species metabolic process
D2	1902600	biological_process	proton transmembrane transport
D3	0005739	cellular_component	mitochondrion
D3	0005743	cellular_component	mitochondrial inner membrane
D3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D3	0030964	cellular_component	NADH dehydrogenase complex
D3	0045271	cellular_component	respiratory chain complex I
D3	1902600	biological_process	proton transmembrane transport
D4	0003954	molecular_function	NADH dehydrogenase activity
D4	0005739	cellular_component	mitochondrion
D4	0005743	cellular_component	mitochondrial inner membrane
D4	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D4	0009060	biological_process	aerobic respiration
D4	0015990	biological_process	electron transport coupled proton transport
D4	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D4	0042773	biological_process	ATP synthesis coupled electron transport
D4	0045271	cellular_component	respiratory chain complex I
D4	0048039	molecular_function	ubiquinone binding
D5	0003954	molecular_function	NADH dehydrogenase activity
D5	0005739	cellular_component	mitochondrion
D5	0005743	cellular_component	mitochondrial inner membrane
D5	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D5	0015990	biological_process	electron transport coupled proton transport
D5	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D5	0042773	biological_process	ATP synthesis coupled electron transport
D5	0045271	cellular_component	respiratory chain complex I
D6	0005739	cellular_component	mitochondrion
D6	0005743	cellular_component	mitochondrial inner membrane
D6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D6	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D6	1902600	biological_process	proton transmembrane transport
S2	0005739	cellular_component	mitochondrion
S2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S2	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S2	0048038	molecular_function	quinone binding
S2	0051287	molecular_function	NAD binding
S2	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 3PE D6 501

Chain	Residue
AM	ILE140
D6	SER50
D6	LEU54
AM	THR143
D1	MET98
D1	ASN99
D1	PHE104
D3	LEU3
D6	GLY38
D6	LEU45
D6	ASN46

site_id	AC2
Number of Residues	8
Details	binding site for residue CDL D5 901

Chain	Residue
B5	ASP18
B5	LEU22
D5	ASN23
D5	GLN116
D5	LYS119
D5	TYR120
D5	LEU123
D5	MET150

site_id	AC3
Number of Residues	13
Details	binding site for residue 3PE D5 902

Chain	Residue
B8	ASN87
B8	ARG88
B8	ASP90
D4	LEU405
D5	ASP163
D5	THR166
D5	LEU169
D5	GLN170
D5	TYR174
D5	HIS534
D5	THR537
D5	PRO538
D5	ASN541

site_id	AC4
Number of Residues	11
Details	binding site for residue 3PE D5 903

Chain	Residue
D2	LEU288
D2	TYR291
D4	LEU147
D4	TYR148
D4	PHE151
D4	TYR152
D5	SER567
D5	GLN570
S2	GLN13
S2	MET19
S2	TYR20

site_id	AC5
Number of Residues	7
Details	binding site for residue CDL D5 904

Chain	Residue
AK	ALA112
AK	TYR116
AK	CDL501
D5	THR565
D5	LYS572
D5	MET573
D5	THR576

site_id	AC6
Number of Residues	9
Details	binding site for residue PC1 D4 701

Chain	Residue
B5	CDL201
BK	SER74
BK	VAL77
BK	ALA78
D4	LEU68
D4	LEU446
D4	LEU447
D4	ASN450
D5	TRP66

site_id	AC7
Number of Residues	7
Details	binding site for residue 3PE D4 702

Chain	Residue
A8	3PE301
B1	ASN30
C2	PRO29
D4	LEU2
D4	SER53
D4	THR55
D4	MET108

site_id	AC8
Number of Residues	3
Details	binding site for residue PC1 D4 703

Chain	Residue
AK	TRP132
D2	ILE276
D4	SER191

site_id	AC9
Number of Residues	10
Details	binding site for residue CDL AK 501

Chain	Residue
AK	TYR38
AK	LEU42
AK	LYS43
AK	TYR58
AK	LEU100
AK	THR104
D2	PHE113
D2	LEU160
D5	THR576
D5	CDL904

site_id	AD1
Number of Residues	8
Details	binding site for residue CDL B5 201

Chain	Residue
B5	ILE40
B5	ASN44
B5	GLU49
B5	HIS69
B6	TRP79
B6	TYR83
B6	HIS88
D4	PC1701

site_id	AD2
Number of Residues	9
Details	binding site for residue ZMP AB 101

Chain	Residue
AB	ASP43
AB	SER44
B9	HIS11
B9	GLN12
B9	HIS50
B9	LYS51
B9	LEU62
B9	LEU63
B9	ALA66

site_id	AD3
Number of Residues	5
Details	binding site for residue 3PE A8 301

Chain	Residue
B1	LYS33
D4	3PE702
A8	TRP169
A8	THR170
A8	MET171

site_id	AD4
Number of Residues	4
Details	binding site for residue 3PE B4 201

Chain	Residue
AK	TYR107
AK	GLY108
B4	PRO81
B4	SER86

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
AB	ASP39-MET54

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
AB	ASP64-ILE76

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
S2	LEU83-LYS94

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE

Chain	Residue	Details
D1	GLY44-GLU59

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
D1	PRO197-GLY210

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
D2	PRO3-SER23
D2	ASP274-MET294
D2	LEU325-ILE345
D5	MET366-LEU386
D5	LEU413-GLY433
D5	LEU457-ILE477
D5	TYR485-SER505
D5	GLY582-LEU602
D2	HIS25-MET45
D2	SER67-MET87
D2	MET96-PRO116
D2	ILE122-LEU142
D2	ILE145-GLY165
D2	ILE178-PRO198
D2	MET200-MET220
D2	ALA237-LEU257

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)