6Q8I

Nterminal domain of human SMU1 in complex with human REDmid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016607	cellular_component	nuclear speck
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071011	cellular_component	precatalytic spliceosome
B	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016607	cellular_component	nuclear speck
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071011	cellular_component	precatalytic spliceosome
C	0000228	cellular_component	nuclear chromosome
C	0000278	biological_process	mitotic cell cycle
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005694	cellular_component	chromosome
C	0006397	biological_process	mRNA processing
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0034501	biological_process	protein localization to kinetochore
C	0042802	molecular_function	identical protein binding
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0097431	cellular_component	mitotic spindle pole
D	0000228	cellular_component	nuclear chromosome
D	0000278	biological_process	mitotic cell cycle
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0000922	cellular_component	spindle pole
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005694	cellular_component	chromosome
D	0006397	biological_process	mRNA processing
D	0007094	biological_process	mitotic spindle assembly checkpoint signaling
D	0008380	biological_process	RNA splicing
D	0016607	cellular_component	nuclear speck
D	0034501	biological_process	protein localization to kinetochore
D	0042802	molecular_function	identical protein binding
D	0071005	cellular_component	U2-type precatalytic spliceosome
D	0097431	cellular_component	mitotic spindle pole
E	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071011	cellular_component	precatalytic spliceosome
F	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0016607	cellular_component	nuclear speck
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071011	cellular_component	precatalytic spliceosome
G	0000228	cellular_component	nuclear chromosome
G	0000278	biological_process	mitotic cell cycle
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0000922	cellular_component	spindle pole
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005694	cellular_component	chromosome
G	0006397	biological_process	mRNA processing
G	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0008380	biological_process	RNA splicing
G	0016607	cellular_component	nuclear speck
G	0034501	biological_process	protein localization to kinetochore
G	0042802	molecular_function	identical protein binding
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0097431	cellular_component	mitotic spindle pole
H	0000228	cellular_component	nuclear chromosome
H	0000278	biological_process	mitotic cell cycle
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0000922	cellular_component	spindle pole
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005694	cellular_component	chromosome
H	0006397	biological_process	mRNA processing
H	0007094	biological_process	mitotic spindle assembly checkpoint signaling
H	0008380	biological_process	RNA splicing
H	0016607	cellular_component	nuclear speck
H	0034501	biological_process	protein localization to kinetochore
H	0042802	molecular_function	identical protein binding
H	0071005	cellular_component	U2-type precatalytic spliceosome
H	0097431	cellular_component	mitotic spindle pole
I	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0016607	cellular_component	nuclear speck
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071011	cellular_component	precatalytic spliceosome
J	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0016607	cellular_component	nuclear speck
J	0071005	cellular_component	U2-type precatalytic spliceosome
J	0071011	cellular_component	precatalytic spliceosome
K	0000228	cellular_component	nuclear chromosome
K	0000278	biological_process	mitotic cell cycle
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000922	cellular_component	spindle pole
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005694	cellular_component	chromosome
K	0006397	biological_process	mRNA processing
K	0007094	biological_process	mitotic spindle assembly checkpoint signaling
K	0008380	biological_process	RNA splicing
K	0016607	cellular_component	nuclear speck
K	0034501	biological_process	protein localization to kinetochore
K	0042802	molecular_function	identical protein binding
K	0071005	cellular_component	U2-type precatalytic spliceosome
K	0097431	cellular_component	mitotic spindle pole
L	0000228	cellular_component	nuclear chromosome
L	0000278	biological_process	mitotic cell cycle
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000922	cellular_component	spindle pole
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005694	cellular_component	chromosome
L	0006397	biological_process	mRNA processing
L	0007094	biological_process	mitotic spindle assembly checkpoint signaling
L	0008380	biological_process	RNA splicing
L	0016607	cellular_component	nuclear speck
L	0034501	biological_process	protein localization to kinetochore
L	0042802	molecular_function	identical protein binding
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0097431	cellular_component	mitotic spindle pole
M	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0016607	cellular_component	nuclear speck
M	0071005	cellular_component	U2-type precatalytic spliceosome
M	0071011	cellular_component	precatalytic spliceosome
N	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0016607	cellular_component	nuclear speck
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0071011	cellular_component	precatalytic spliceosome
O	0000228	cellular_component	nuclear chromosome
O	0000278	biological_process	mitotic cell cycle
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000922	cellular_component	spindle pole
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005694	cellular_component	chromosome
O	0006397	biological_process	mRNA processing
O	0007094	biological_process	mitotic spindle assembly checkpoint signaling
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0034501	biological_process	protein localization to kinetochore
O	0042802	molecular_function	identical protein binding
O	0071005	cellular_component	U2-type precatalytic spliceosome
O	0097431	cellular_component	mitotic spindle pole
P	0000228	cellular_component	nuclear chromosome
P	0000278	biological_process	mitotic cell cycle
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000922	cellular_component	spindle pole
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005694	cellular_component	chromosome
P	0006397	biological_process	mRNA processing
P	0007094	biological_process	mitotic spindle assembly checkpoint signaling
P	0008380	biological_process	RNA splicing
P	0016607	cellular_component	nuclear speck
P	0034501	biological_process	protein localization to kinetochore
P	0042802	molecular_function	identical protein binding
P	0071005	cellular_component	U2-type precatalytic spliceosome
P	0097431	cellular_component	mitotic spindle pole

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTGsvDgFIEVWNF

Chain	Residue	Details
A	LEU229-PHE243
A	ILE364-MET378

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	256
Details	Domain: {"description":"LisH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00126","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	364
Details	Domain: {"description":"CTLH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00058","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Zebisch A.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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