6Q7H

RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 9 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue HL8 A 501

Chain	Residue
A	CYS320
A	HIS479
A	LEU483
A	HOH619
A	HOH625
A	LEU324
A	MET358
A	LEU362
A	MET365
A	PHE377
A	PHE378
A	PHE388
A	LEU391

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site_id	AC2
Number of Residues	8
Details	binding site for residue HL8 A 502

Chain	Residue
A	ILE328
A	GLN329
A	VAL332
A	LYS336
A	LEU353
A	ALA357
A	HOH601
A	HOH612

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