6Q6H

Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005680	cellular_component	anaphase-promoting complex
A	0005829	cellular_component	cytosol
A	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016567	biological_process	protein ubiquitination
A	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
A	0051301	biological_process	cell division
A	0051445	biological_process	regulation of meiotic cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
A	0141198	biological_process	protein branched polyubiquitination
C	0000278	biological_process	mitotic cell cycle
C	0001664	molecular_function	G protein-coupled receptor binding
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005680	cellular_component	anaphase-promoting complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007346	biological_process	regulation of mitotic cell cycle
C	0008270	molecular_function	zinc ion binding
C	0016567	biological_process	protein ubiquitination
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0046872	molecular_function	metal ion binding
C	0051301	biological_process	cell division
C	0051445	biological_process	regulation of meiotic cell cycle
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070936	biological_process	protein K48-linked ubiquitination
C	0070979	biological_process	protein K11-linked ubiquitination
C	0097602	molecular_function	cullin family protein binding
C	0141198	biological_process	protein branched polyubiquitination
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005680	cellular_component	anaphase-promoting complex
D	0005829	cellular_component	cytosol
D	0007346	biological_process	regulation of mitotic cell cycle
D	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
D	0051301	biological_process	cell division
D	0051445	biological_process	regulation of meiotic cell cycle
D	0070936	biological_process	protein K48-linked ubiquitination
D	0070979	biological_process	protein K11-linked ubiquitination
D	0090266	biological_process	regulation of mitotic cell cycle spindle assembly checkpoint
D	0141198	biological_process	protein branched polyubiquitination
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005680	cellular_component	anaphase-promoting complex
G	0005829	cellular_component	cytosol
G	0007346	biological_process	regulation of mitotic cell cycle
G	0016567	biological_process	protein ubiquitination
G	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
G	0051301	biological_process	cell division
G	0051445	biological_process	regulation of meiotic cell cycle
G	0070936	biological_process	protein K48-linked ubiquitination
G	0070979	biological_process	protein K11-linked ubiquitination
G	0141198	biological_process	protein branched polyubiquitination
H	0000775	cellular_component	chromosome, centromeric region
H	0000776	cellular_component	kinetochore
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005680	cellular_component	anaphase-promoting complex
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007346	biological_process	regulation of mitotic cell cycle
H	0016567	biological_process	protein ubiquitination
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0051301	biological_process	cell division
H	0051445	biological_process	regulation of meiotic cell cycle
H	0070936	biological_process	protein K48-linked ubiquitination
H	0070979	biological_process	protein K11-linked ubiquitination
H	0141198	biological_process	protein branched polyubiquitination
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005680	cellular_component	anaphase-promoting complex
I	0005829	cellular_component	cytosol
I	0007346	biological_process	regulation of mitotic cell cycle
I	0016567	biological_process	protein ubiquitination
I	0019903	molecular_function	protein phosphatase binding
I	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0034399	cellular_component	nuclear periphery
I	0051301	biological_process	cell division
I	0051445	biological_process	regulation of meiotic cell cycle
I	0070936	biological_process	protein K48-linked ubiquitination
I	0070979	biological_process	protein K11-linked ubiquitination
I	0141198	biological_process	protein branched polyubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005680	cellular_component	anaphase-promoting complex
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
J	0007346	biological_process	regulation of mitotic cell cycle
J	0016567	biological_process	protein ubiquitination
J	0019903	molecular_function	protein phosphatase binding
J	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
J	0031175	biological_process	neuron projection development
J	0051301	biological_process	cell division
J	0051445	biological_process	regulation of meiotic cell cycle
J	0070936	biological_process	protein K48-linked ubiquitination
J	0070979	biological_process	protein K11-linked ubiquitination
J	0072686	cellular_component	mitotic spindle
J	0141198	biological_process	protein branched polyubiquitination
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005680	cellular_component	anaphase-promoting complex
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0007346	biological_process	regulation of mitotic cell cycle
K	0016567	biological_process	protein ubiquitination
K	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
K	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
K	0051301	biological_process	cell division
K	0051445	biological_process	regulation of meiotic cell cycle
K	0070936	biological_process	protein K48-linked ubiquitination
K	0070979	biological_process	protein K11-linked ubiquitination
K	0072686	cellular_component	mitotic spindle
K	0141198	biological_process	protein branched polyubiquitination
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005680	cellular_component	anaphase-promoting complex
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007346	biological_process	regulation of mitotic cell cycle
L	0016567	biological_process	protein ubiquitination
L	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
L	0051301	biological_process	cell division
L	0051445	biological_process	regulation of meiotic cell cycle
L	0070936	biological_process	protein K48-linked ubiquitination
L	0070979	biological_process	protein K11-linked ubiquitination
L	0141198	biological_process	protein branched polyubiquitination
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005680	cellular_component	anaphase-promoting complex
M	0007346	biological_process	regulation of mitotic cell cycle
M	0016567	biological_process	protein ubiquitination
M	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
M	0051301	biological_process	cell division
M	0051445	biological_process	regulation of meiotic cell cycle
M	0070936	biological_process	protein K48-linked ubiquitination
M	0070979	biological_process	protein K11-linked ubiquitination
M	0141198	biological_process	protein branched polyubiquitination
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005680	cellular_component	anaphase-promoting complex
N	0005829	cellular_component	cytosol
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
N	0007346	biological_process	regulation of mitotic cell cycle
N	0007399	biological_process	nervous system development
N	0010498	biological_process	proteasomal protein catabolic process
N	0010629	biological_process	negative regulation of gene expression
N	0016567	biological_process	protein ubiquitination
N	0030154	biological_process	cell differentiation
N	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
N	0031461	cellular_component	cullin-RING ubiquitin ligase complex
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0031915	biological_process	positive regulation of synaptic plasticity
N	0045773	biological_process	positive regulation of axon extension
N	0050775	biological_process	positive regulation of dendrite morphogenesis
N	0051301	biological_process	cell division
N	0051445	biological_process	regulation of meiotic cell cycle
N	0070936	biological_process	protein K48-linked ubiquitination
N	0070979	biological_process	protein K11-linked ubiquitination
N	0090129	biological_process	positive regulation of synapse maturation
N	0141198	biological_process	protein branched polyubiquitination
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005680	cellular_component	anaphase-promoting complex
O	0005737	cellular_component	cytoplasm
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0007346	biological_process	regulation of mitotic cell cycle
O	0016567	biological_process	protein ubiquitination
O	0019903	molecular_function	protein phosphatase binding
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0051301	biological_process	cell division
O	0051445	biological_process	regulation of meiotic cell cycle
O	0070936	biological_process	protein K48-linked ubiquitination
O	0070979	biological_process	protein K11-linked ubiquitination
O	0141198	biological_process	protein branched polyubiquitination
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005680	cellular_component	anaphase-promoting complex
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
P	0007346	biological_process	regulation of mitotic cell cycle
P	0016567	biological_process	protein ubiquitination
P	0019903	molecular_function	protein phosphatase binding
P	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
P	0031175	biological_process	neuron projection development
P	0051301	biological_process	cell division
P	0051445	biological_process	regulation of meiotic cell cycle
P	0070936	biological_process	protein K48-linked ubiquitination
P	0070979	biological_process	protein K11-linked ubiquitination
P	0072686	cellular_component	mitotic spindle
P	0141198	biological_process	protein branched polyubiquitination
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005680	cellular_component	anaphase-promoting complex
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0007346	biological_process	regulation of mitotic cell cycle
Q	0016567	biological_process	protein ubiquitination
Q	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Q	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
Q	0051301	biological_process	cell division
Q	0051445	biological_process	regulation of meiotic cell cycle
Q	0070936	biological_process	protein K48-linked ubiquitination
Q	0070979	biological_process	protein K11-linked ubiquitination
Q	0072686	cellular_component	mitotic spindle
Q	0141198	biological_process	protein branched polyubiquitination
R	0000086	biological_process	G2/M transition of mitotic cell cycle
R	0000775	cellular_component	chromosome, centromeric region
R	0000776	cellular_component	kinetochore
R	0000922	cellular_component	spindle pole
R	0005515	molecular_function	protein binding
R	0005654	cellular_component	nucleoplasm
R	0005680	cellular_component	anaphase-promoting complex
R	0005694	cellular_component	chromosome
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005819	cellular_component	spindle
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0007064	biological_process	mitotic sister chromatid cohesion
R	0007094	biological_process	mitotic spindle assembly checkpoint signaling
R	0007346	biological_process	regulation of mitotic cell cycle
R	0007399	biological_process	nervous system development
R	0008284	biological_process	positive regulation of cell population proliferation
R	0010997	molecular_function	anaphase-promoting complex binding
R	0016567	biological_process	protein ubiquitination
R	0016579	biological_process	protein deubiquitination
R	0030154	biological_process	cell differentiation
R	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031915	biological_process	positive regulation of synaptic plasticity
R	0032991	cellular_component	protein-containing complex
R	0033597	cellular_component	mitotic checkpoint complex
R	0040020	biological_process	regulation of meiotic nuclear division
R	0042826	molecular_function	histone deacetylase binding
R	0044784	biological_process	metaphase/anaphase transition of cell cycle
R	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0050773	biological_process	regulation of dendrite development
R	0051301	biological_process	cell division
R	0051445	biological_process	regulation of meiotic cell cycle
R	0090129	biological_process	positive regulation of synapse maturation
R	0090307	biological_process	mitotic spindle assembly
R	0097027	molecular_function	ubiquitin-protein transferase activator activity
R	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
R	1905786	biological_process	positive regulation of anaphase-promoting complex-dependent catabolic process
R	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
R	1990757	molecular_function	ubiquitin ligase activator activity
R	1990949	biological_process	metaphase/anaphase transition of meiosis I
S	0000082	biological_process	G1/S transition of mitotic cell cycle
S	0000086	biological_process	G2/M transition of mitotic cell cycle
S	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
S	0001939	cellular_component	female pronucleus
S	0001940	cellular_component	male pronucleus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005815	cellular_component	microtubule organizing center
S	0005829	cellular_component	cytosol
S	0006275	biological_process	regulation of DNA replication
S	0006351	biological_process	DNA-templated transcription
S	0007265	biological_process	Ras protein signal transduction
S	0016538	molecular_function	cyclin-dependent protein serine/threonine kinase regulator activity
S	0019901	molecular_function	protein kinase binding
S	0019904	molecular_function	protein domain specific binding
S	0031100	biological_process	animal organ regeneration
S	0032355	biological_process	response to estradiol
S	0033762	biological_process	response to glucagon
S	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
S	0043687	biological_process	post-translational protein modification
S	0044320	biological_process	cellular response to leptin stimulus
S	0044772	biological_process	mitotic cell cycle phase transition
S	0044843	biological_process	cell cycle G1/S phase transition
S	0045893	biological_process	positive regulation of DNA-templated transcription
S	0048146	biological_process	positive regulation of fibroblast proliferation
S	0051301	biological_process	cell division
S	0071314	biological_process	cellular response to cocaine
S	0071373	biological_process	cellular response to luteinizing hormone stimulus
S	0071392	biological_process	cellular response to estradiol stimulus
S	0071456	biological_process	cellular response to hypoxia
S	0071732	biological_process	cellular response to nitric oxide
S	0090102	biological_process	cochlea development
S	0097122	cellular_component	cyclin A2-CDK1 complex
S	0097124	cellular_component	cyclin A2-CDK2 complex
S	1990314	biological_process	cellular response to insulin-like growth factor stimulus
S	2000573	biological_process	positive regulation of DNA biosynthetic process
U	0000278	biological_process	mitotic cell cycle
U	0004842	molecular_function	ubiquitin-protein transferase activity
U	0005515	molecular_function	protein binding
U	0005654	cellular_component	nucleoplasm
U	0005680	cellular_component	anaphase-promoting complex
U	0005829	cellular_component	cytosol
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0007080	biological_process	mitotic metaphase chromosome alignment
U	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
U	0007096	biological_process	regulation of exit from mitosis
U	0007346	biological_process	regulation of mitotic cell cycle
U	0016567	biological_process	protein ubiquitination
U	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
U	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
U	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
U	0051301	biological_process	cell division
U	0051445	biological_process	regulation of meiotic cell cycle
U	0070936	biological_process	protein K48-linked ubiquitination
U	0070979	biological_process	protein K11-linked ubiquitination
U	0141198	biological_process	protein branched polyubiquitination
V	0000278	biological_process	mitotic cell cycle
V	0004842	molecular_function	ubiquitin-protein transferase activity
V	0005515	molecular_function	protein binding
V	0005654	cellular_component	nucleoplasm
V	0005680	cellular_component	anaphase-promoting complex
V	0005829	cellular_component	cytosol
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0007080	biological_process	mitotic metaphase chromosome alignment
V	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
V	0007096	biological_process	regulation of exit from mitosis
V	0007346	biological_process	regulation of mitotic cell cycle
V	0016567	biological_process	protein ubiquitination
V	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
V	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
V	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
V	0051301	biological_process	cell division
V	0051445	biological_process	regulation of meiotic cell cycle
V	0070936	biological_process	protein K48-linked ubiquitination
V	0070979	biological_process	protein K11-linked ubiquitination
V	0141198	biological_process	protein branched polyubiquitination
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005680	cellular_component	anaphase-promoting complex
W	0005829	cellular_component	cytosol
W	0007346	biological_process	regulation of mitotic cell cycle
W	0016567	biological_process	protein ubiquitination
W	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
W	0051301	biological_process	cell division
W	0051445	biological_process	regulation of meiotic cell cycle
W	0070936	biological_process	protein K48-linked ubiquitination
W	0070979	biological_process	protein K11-linked ubiquitination
W	0141198	biological_process	protein branched polyubiquitination
Y	0000792	cellular_component	heterochromatin
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005680	cellular_component	anaphase-promoting complex
Y	0005737	cellular_component	cytoplasm
Y	0005819	cellular_component	spindle
Y	0005829	cellular_component	cytosol
Y	0005856	cellular_component	cytoskeleton
Y	0007346	biological_process	regulation of mitotic cell cycle
Y	0007420	biological_process	brain development
Y	0015630	cellular_component	microtubule cytoskeleton
Y	0016567	biological_process	protein ubiquitination
Y	0019903	molecular_function	protein phosphatase binding
Y	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Y	0045171	cellular_component	intercellular bridge
Y	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
Y	0051301	biological_process	cell division
Y	0051445	biological_process	regulation of meiotic cell cycle
Y	0070936	biological_process	protein K48-linked ubiquitination
Y	0070979	biological_process	protein K11-linked ubiquitination
Y	0072686	cellular_component	mitotic spindle
Y	0140767	molecular_function	enzyme-substrate adaptor activity
Y	0141198	biological_process	protein branched polyubiquitination
Z	0000792	cellular_component	heterochromatin
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005680	cellular_component	anaphase-promoting complex
Z	0005737	cellular_component	cytoplasm
Z	0005819	cellular_component	spindle
Z	0005829	cellular_component	cytosol
Z	0005856	cellular_component	cytoskeleton
Z	0007346	biological_process	regulation of mitotic cell cycle
Z	0007420	biological_process	brain development
Z	0015630	cellular_component	microtubule cytoskeleton
Z	0016567	biological_process	protein ubiquitination
Z	0019903	molecular_function	protein phosphatase binding
Z	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Z	0045171	cellular_component	intercellular bridge
Z	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
Z	0051301	biological_process	cell division
Z	0051445	biological_process	regulation of meiotic cell cycle
Z	0070936	biological_process	protein K48-linked ubiquitination
Z	0070979	biological_process	protein K11-linked ubiquitination
Z	0072686	cellular_component	mitotic spindle
Z	0140767	molecular_function	enzyme-substrate adaptor activity
Z	0141198	biological_process	protein branched polyubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00292
Number of Residues	32
Details	CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF

Chain	Residue	Details
S	ARG211-PHE242

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site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. TGGGtsDrHIRIWNV

Chain	Residue	Details
R	THR373-VAL387

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER51
V	ALA2
P	THR205
P	THR446
Q	SER490
Q	SER595

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER60
C	CYS59
C	CYS73
C	CYS76
V	TYR273
J	THR313
J	THR430
P	THR209
P	THR244
P	THR313
P	THR430
C	HIS58

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031

Chain	Residue	Details
A	SER202
A	SER375
A	ASP462
P	SER435

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR380
R	SER92
R	SER153
R	SER161

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	PRO402
A	ILE432
A	SER1005

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	VAL430
V	SER578

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	PHE444
V	THR582
R	LYS490

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLN451
V	SER588

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	LEU466
V	SER593

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14657031

Chain	Residue	Details
A	LYS626
V	THR596

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	GLN636
V	LYS147

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	VAL644

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:14657031

Chain	Residue	Details
A	PHE660

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	LEU775

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR777

---