Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q4N

Fusidic acid bound AcrB_V340A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue P6G A 1101

Chain	Residue
A	GLY957
A	GLY959
A	ARG1031
A	LYS1036

site_id	AC2
Number of Residues	6
Details	binding site for residue FUA A 1102

Chain	Residue
A	LMT1104
A	GLY24
A	ILE27
A	LYS334
A	HIS338
A	VAL341

site_id	AC3
Number of Residues	6
Details	binding site for residue LMT A 1103

Chain	Residue
A	GLY440
A	GLY444
A	CYS887
A	ALA890
A	LEU891
C	ARG8

site_id	AC4
Number of Residues	7
Details	binding site for residue LMT A 1104

Chain	Residue
A	ILE27
A	LEU28
A	VAL32
A	VAL341
A	PHE380
A	ILE390
A	FUA1102

site_id	AC5
Number of Residues	6
Details	binding site for residue LMT A 1105

Chain	Residue
A	SER530
A	GLY533
A	ARG536
A	SER537
A	ARG540
A	TYR541

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 1106

Chain	Residue
A	GLY51
A	TRP754
A	GLY755
A	MET774
C	GLN218
C	GLY221

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL A 1107

Chain	Residue
A	ARG168
A	GLU309
A	HOH1208
B	LEU75
B	MET78
B	ASN820

site_id	AC8
Number of Residues	6
Details	binding site for residue FUA B 1101

Chain	Residue
B	LEU300
B	LYS334
B	ILE337
B	HIS338
B	VAL341
B	LMT1103

site_id	AC9
Number of Residues	9
Details	binding site for residue LMT B 1102

Chain	Residue
B	SER530
B	ARG536
B	SER537
B	ARG540
B	TYR541
B	VAL1016
B	PHE1020
B	D101112
D	ASP72

site_id	AD1
Number of Residues	8
Details	binding site for residue LMT B 1103

Chain	Residue
B	ASN298
B	LEU300
B	ASP301
B	LYS334
B	VAL341
B	PHE380
B	ILE390
B	FUA1101

site_id	AD2
Number of Residues	5
Details	binding site for residue LMT B 1104

Chain	Residue
B	GLY436
B	VAL443
B	GLY444
B	CYS887
B	LYS955

site_id	AD3
Number of Residues	10
Details	binding site for residue PTY B 1105

Chain	Residue
B	LEU30
B	PRO31
B	ALA381
B	ALA384
B	ALA385
B	GLY387
B	PHE388
B	DDQ1113
B	D121117
C	PTY1104

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL B 1106

Chain	Residue
B	GLN112
B	MET115
B	VAL127
C	GLN112

site_id	AD5
Number of Residues	1
Details	binding site for residue OCT B 1108

Chain	Residue
B	HIS526

site_id	AD6
Number of Residues	4
Details	binding site for residue D10 B 1109

Chain	Residue
B	PHE386
B	ALA457
B	ARG468
B	VAL475

site_id	AD7
Number of Residues	1
Details	binding site for residue D10 B 1110

Chain	Residue
B	SER450

site_id	AD8
Number of Residues	2
Details	binding site for residue D10 B 1111

Chain	Residue
B	ILE882
B	TRP895

site_id	AD9
Number of Residues	1
Details	binding site for residue D10 B 1112

Chain	Residue
B	LMT1102

site_id	AE1
Number of Residues	3
Details	binding site for residue DDQ B 1113

Chain	Residue
B	MET1
B	PHE5
B	PTY1105

site_id	AE2
Number of Residues	5
Details	binding site for residue SO4 B 1115

Chain	Residue
C	GLN120
B	ARG239
B	ASN760
B	ASP761
C	PRO119

site_id	AE3
Number of Residues	7
Details	binding site for residue DDR B 1116

Chain	Residue
B	PHE459
B	MET552
B	TYR877
B	SER880
B	LEU881
B	GLN928
B	LEU932

site_id	AE4
Number of Residues	3
Details	binding site for residue D12 B 1117

Chain	Residue
B	ALA385
B	PHE386
B	PTY1105

site_id	AE5
Number of Residues	4
Details	binding site for residue FUA C 1101

Chain	Residue
C	ILE27
C	LYS334
C	HIS338
C	VAL341

site_id	AE6
Number of Residues	9
Details	binding site for residue LMT C 1102

Chain	Residue
C	SER530
C	GLY533
C	ARG536
C	SER537
C	ARG540
C	TYR541
C	ILE548
C	PHE1020
C	OCT1108

site_id	AE7
Number of Residues	4
Details	binding site for residue LMT C 1103

Chain	Residue
C	THR917
C	PHE918
C	ARG919
C	GLY1009

site_id	AE8
Number of Residues	6
Details	binding site for residue PTY C 1104

Chain	Residue
B	LYS29
B	PTY1105
C	PHE458
C	PHE459
C	SER875
C	PTY1106

site_id	AE9
Number of Residues	6
Details	binding site for residue PTY C 1105

Chain	Residue
B	TRP13
C	SER894
C	TRP895
C	SER896
C	ARG1030
C	HOH1212

site_id	AF1
Number of Residues	10
Details	binding site for residue PTY C 1106

Chain	Residue
B	ARG8
B	PHE11
C	GLN439
C	GLY440
C	MET447
C	LEU891
C	TYR892
C	GLU947
C	ASP951
C	PTY1104

site_id	AF2
Number of Residues	5
Details	binding site for residue GOL C 1107

Chain	Residue
C	ARG185
C	GLU273
C	GLY755
C	GLY756
C	TYR772

site_id	AF3
Number of Residues	2
Details	binding site for residue OCT C 1108

Chain	Residue
C	SER530
C	LMT1102

site_id	AF4
Number of Residues	2
Details	binding site for residue D10 C 1111

Chain	Residue
C	PHE556
C	HEX1113

site_id	AF5
Number of Residues	2
Details	binding site for residue DDQ C 1112

Chain	Residue
C	ARG468
C	SER471

site_id	AF6
Number of Residues	2
Details	binding site for residue HEX C 1113

Chain	Residue
C	PHE556
C	D101111

site_id	AF7
Number of Residues	3
Details	binding site for residue SO4 C 1114

Chain	Residue
C	LYS55
C	GLY691
C	HIS692

site_id	AF8
Number of Residues	4
Details	binding site for residue GOL E 201

Chain	Residue
A	TYR811
E	GLU20
E	ARG23
E	ASP44

site_id	AF9
Number of Residues	3
Details	binding site for residue GOL E 202

Chain	Residue
E	ARG23
E	TRP57
E	HOH303

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	462
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	MET1-PRO9
B	GLU414-ILE438
B	ALA491-THR538
B	ALA889-PRO898
B	LEU944-LEU972
B	ILE1019-HIS1049
C	MET1-PRO9
C	LEU357-THR365
C	GLU414-ILE438
C	ALA491-THR538
C	ALA889-PRO898
A	LEU357-THR365
C	LEU944-LEU972
C	ILE1019-HIS1049
A	GLU414-ILE438
A	ALA491-THR538
A	ALA889-PRO898
A	LEU944-LEU972
A	ILE1019-HIS1049
B	MET1-PRO9
B	LEU357-THR365

site_id	SWS_FT_FI2
Number of Residues	54
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	ILE10-LEU28
B	ILE10-LEU28
C	ILE10-LEU28

site_id	SWS_FT_FI3
Number of Residues	1932
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15919996

Chain	Residue	Details
A	LYS29-SER336
B	PHE556-ASN871
B	ARG919-ASP924
B	THR993-GLY998
C	LYS29-SER336
C	PHE386-ASN391
C	PHE458-ALA465
C	PHE556-ASN871
C	ARG919-ASP924
C	THR993-GLY998
A	PHE386-ASN391
A	PHE458-ALA465
A	PHE556-ASN871
A	ARG919-ASP924
A	THR993-GLY998
B	LYS29-SER336
B	PHE386-ASN391
B	PHE458-ALA465

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ILE337-TYR356
B	ILE337-TYR356
C	ILE337-TYR356

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU366-ALA385
B	LEU366-ALA385
C	LEU366-ALA385

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	THR392-VAL413
B	THR392-VAL413
C	THR392-VAL413

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	GLN439-ALA457
B	GLN439-ALA457
C	GLN439-ALA457

site_id	SWS_FT_FI8
Number of Residues	72
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ILE466-PRO490
B	ILE466-PRO490
C	ILE466-PRO490

site_id	SWS_FT_FI9
Number of Residues	48
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	GLY539-LEU555
B	GLY539-LEU555
C	GLY539-LEU555

site_id	SWS_FT_FI10
Number of Residues	48
Details	TRANSMEM: Helical; Name=8

Chain	Residue	Details
A	GLN872-LEU888
B	GLN872-LEU888
C	GLN872-LEU888

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9

Chain	Residue	Details
A	PHE899-PHE918
B	PHE899-PHE918
C	PHE899-PHE918

site_id	SWS_FT_FI12
Number of Residues	54
Details	TRANSMEM: Helical; Name=10

Chain	Residue	Details
A	VAL925-ILE943
B	VAL925-ILE943
C	VAL925-ILE943

site_id	SWS_FT_FI13
Number of Residues	57
Details	TRANSMEM: Helical; Name=11

Chain	Residue	Details
A	ARG973-SER992
B	ARG973-SER992
C	ARG973-SER992

site_id	SWS_FT_FI14
Number of Residues	57
Details	TRANSMEM: Helical; Name=12

Chain	Residue	Details
A	ALA999-ALA1018
B	ALA999-ALA1018
C	ALA999-ALA1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)