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6Q3Z

Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k

Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue HG8 A 201
ChainResidue
ATRP81
AILE146
AEDO204
AHOH320
AHOH331
AHOH337
BHIS77
BGLN78
BPHE79
BASP145
BLEU148
APRO82
BMET149
AGLN85
AVAL87
ALEU92
ALEU94
ATYR97
AASN140
AASP145

site_idAC2
Number of Residues5
Detailsbinding site for residue EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC3
Number of Residues3
Detailsbinding site for residue EDO A 203
ChainResidue
AGLN78
ATRP81
BLYS155

site_idAC4
Number of Residues7
Detailsbinding site for residue EDO A 204
ChainResidue
APRO86
AASP88
ALYS91
AHG8201
AHOH302
AHOH320
BHOH305

site_idAC5
Number of Residues8
Detailsbinding site for residue EDO A 205
ChainResidue
ALYS111
ALYS112
AGLU115
AILE138
ATYR139
AASN140
ALYS141
AHOH364

site_idAC6
Number of Residues12
Detailsbinding site for residue HG8 B 201
ChainResidue
BTRP81
BPRO82
BGLN85
BVAL87
BLEU92
BLEU94
BASN140
BILE146
BEDO203
BHOH317
BHOH325
BHOH344

site_idAC7
Number of Residues5
Detailsbinding site for residue EDO B 202
ChainResidue
BTRP75
BGLN84
BGLN85
BLYS141
BHOH374

site_idAC8
Number of Residues6
Detailsbinding site for residue EDO B 203
ChainResidue
BPRO86
BVAL87
BASP88
BHG8201
BHOH303
BHOH317

site_idAC9
Number of Residues5
Detailsbinding site for residue EDO B 204
ChainResidue
BILE100
BILE101
BLYS102
BTHR103
BASN135

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99

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PDB entries from 2024-07-17

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