6Q3M
Structure of CHD4 PHD2 - tandem chromodomains
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS464 |
| A | CYS467 |
| A | CYS490 |
| A | CYS493 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 702 |
| Chain | Residue |
| A | CYS452 |
| A | CYS455 |
| A | HIS472 |
| A | CYS475 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PGE A 703 |
| Chain | Residue |
| A | ARG576 |
| A | ASN578 |
| A | MET580 |
| A | GLN575 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PGE A 704 |
| Chain | Residue |
| A | TRP510 |
| A | PRO539 |
| B | ASN528 |
| B | EDO708 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PGE A 705 |
| Chain | Residue |
| A | PHE544 |
| A | CYS555 |
| A | SER556 |
| A | TRP557 |
| A | ARG611 |
| A | TYR615 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 706 |
| Chain | Residue |
| A | ILE627 |
| A | PHE667 |
| A | SER670 |
| A | TYR671 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 707 |
| Chain | Residue |
| A | ARG492 |
| A | GLU564 |
| A | LEU565 |
| A | GLN568 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 708 |
| Chain | Residue |
| A | VAL454 |
| A | LYS456 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 709 |
| Chain | Residue |
| A | CYS467 |
| A | ARG492 |
| A | HOH811 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 710 |
| Chain | Residue |
| A | LYS509 |
| A | EDO713 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 711 |
| Chain | Residue |
| A | GLU540 |
| A | LEU561 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 712 |
| Chain | Residue |
| A | TYR471 |
| A | ARG492 |
| A | LEU561 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 713 |
| Chain | Residue |
| A | GLN542 |
| A | EDO710 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 714 |
| Chain | Residue |
| A | LEU506 |
| A | TYR574 |
| A | ASN578 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 715 |
| Chain | Residue |
| A | SER631 |
| A | TRP654 |
| D | ASP446 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 701 |
| Chain | Residue |
| B | CYS464 |
| B | CYS467 |
| B | CYS490 |
| B | CYS493 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 702 |
| Chain | Residue |
| B | CYS452 |
| B | CYS455 |
| B | HIS472 |
| B | CYS475 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 703 |
| Chain | Residue |
| B | ARG453 |
| B | TYR471 |
| B | LEU476 |
| B | ASN477 |
| B | PRO491 |
| B | ARG492 |
| B | EDO709 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 704 |
| Chain | Residue |
| B | ILE473 |
| B | HIS474 |
| B | PRO479 |
| B | LEU480 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 705 |
| Chain | Residue |
| B | ILE507 |
| B | TRP508 |
| B | LYS509 |
| B | PRO583 |
| B | PRO584 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 706 |
| Chain | Residue |
| B | ASP526 |
| B | EDO707 |
| B | HOH801 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 707 |
| Chain | Residue |
| B | ASP526 |
| B | PRO527 |
| B | EDO706 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 708 |
| Chain | Residue |
| A | PGE704 |
| B | ASP526 |
| B | ASN528 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 709 |
| Chain | Residue |
| B | GLU540 |
| B | PGE703 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 701 |
| Chain | Residue |
| C | CYS464 |
| C | CYS467 |
| C | CYS490 |
| C | CYS493 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 702 |
| Chain | Residue |
| C | CYS452 |
| C | CYS455 |
| C | HIS472 |
| C | CYS475 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue PGE C 703 |
| Chain | Residue |
| C | ARG453 |
| C | TYR471 |
| C | ASN477 |
| C | PRO491 |
| C | ARG492 |
| C | LEU561 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 704 |
| Chain | Residue |
| C | ARG626 |
| C | ILE627 |
| C | PHE667 |
| C | TYR671 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 705 |
| Chain | Residue |
| C | GLN503 |
| C | TYR552 |
| C | GLN651 |
| C | EDO707 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 706 |
| Chain | Residue |
| C | ARG675 |
| C | GLU676 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 707 |
| Chain | Residue |
| C | GLN503 |
| C | GLN651 |
| C | EDO705 |
| D | ASP446 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 708 |
| Chain | Residue |
| C | GLU540 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue PEG C 709 |
| Chain | Residue |
| C | ASP665 |
| C | LYS668 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 701 |
| Chain | Residue |
| D | CYS464 |
| D | CYS467 |
| D | CYS490 |
| D | CYS493 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 702 |
| Chain | Residue |
| D | CYS452 |
| D | CYS455 |
| D | HIS472 |
| D | CYS475 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 703 |
| Chain | Residue |
| D | GLN575 |
| D | ARG576 |
| D | ASN578 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 704 |
| Chain | Residue |
| D | LEU561 |
| D | GLU564 |
Functional Information from PROSITE/UniProt
| site_id | PS00598 |
| Number of Residues | 21 |
| Details | CHROMO_1 Chromo domain signature. FfVKWqGMsywhc.SWVSelqL |
| Chain | Residue | Details |
| A | PHE543-LEU563 | |
| A | TYR640-VAL659 |
| site_id | PS01359 |
| Number of Residues | 42 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CrvCkdggel.......................................LcCdt..Cpss.YHihClnpplpeipnge.................................WlCprC |
| Chain | Residue | Details |
| A | CYS452-CYS493 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 188 |
| Details | Zinc finger: {"description":"PHD-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 81 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"Q12873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
