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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q3M

Structure of CHD4 PHD2 - tandem chromodomains

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 701

Chain	Residue
A	CYS464
A	CYS467
A	CYS490
A	CYS493

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 702

Chain	Residue
A	CYS452
A	CYS455
A	HIS472
A	CYS475

site_id	AC3
Number of Residues	4
Details	binding site for residue PGE A 703

Chain	Residue
A	ARG576
A	ASN578
A	MET580
A	GLN575

site_id	AC4
Number of Residues	4
Details	binding site for residue PGE A 704

Chain	Residue
A	TRP510
A	PRO539
B	ASN528
B	EDO708

site_id	AC5
Number of Residues	6
Details	binding site for residue PGE A 705

Chain	Residue
A	PHE544
A	CYS555
A	SER556
A	TRP557
A	ARG611
A	TYR615

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 706

Chain	Residue
A	ILE627
A	PHE667
A	SER670
A	TYR671

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 707

Chain	Residue
A	ARG492
A	GLU564
A	LEU565
A	GLN568

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 708

Chain	Residue
A	VAL454
A	LYS456

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 709

Chain	Residue
A	CYS467
A	ARG492
A	HOH811

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 710

Chain	Residue
A	LYS509
A	EDO713

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 711

Chain	Residue
A	GLU540
A	LEU561

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO A 712

Chain	Residue
A	TYR471
A	ARG492
A	LEU561

site_id	AD4
Number of Residues	2
Details	binding site for residue EDO A 713

Chain	Residue
A	GLN542
A	EDO710

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO A 714

Chain	Residue
A	LEU506
A	TYR574
A	ASN578

site_id	AD6
Number of Residues	3
Details	binding site for residue PEG A 715

Chain	Residue
A	SER631
A	TRP654
D	ASP446

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN B 701

Chain	Residue
B	CYS464
B	CYS467
B	CYS490
B	CYS493

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN B 702

Chain	Residue
B	CYS452
B	CYS455
B	HIS472
B	CYS475

site_id	AD9
Number of Residues	7
Details	binding site for residue PGE B 703

Chain	Residue
B	ARG453
B	TYR471
B	LEU476
B	ASN477
B	PRO491
B	ARG492
B	EDO709

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO B 704

Chain	Residue
B	ILE473
B	HIS474
B	PRO479
B	LEU480

site_id	AE2
Number of Residues	5
Details	binding site for residue EDO B 705

Chain	Residue
B	ILE507
B	TRP508
B	LYS509
B	PRO583
B	PRO584

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO B 706

Chain	Residue
B	ASP526
B	EDO707
B	HOH801

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO B 707

Chain	Residue
B	ASP526
B	PRO527
B	EDO706

site_id	AE5
Number of Residues	3
Details	binding site for residue EDO B 708

Chain	Residue
A	PGE704
B	ASP526
B	ASN528

site_id	AE6
Number of Residues	2
Details	binding site for residue EDO B 709

Chain	Residue
B	GLU540
B	PGE703

site_id	AE7
Number of Residues	4
Details	binding site for residue ZN C 701

Chain	Residue
C	CYS464
C	CYS467
C	CYS490
C	CYS493

site_id	AE8
Number of Residues	4
Details	binding site for residue ZN C 702

Chain	Residue
C	CYS452
C	CYS455
C	HIS472
C	CYS475

site_id	AE9
Number of Residues	6
Details	binding site for residue PGE C 703

Chain	Residue
C	ARG453
C	TYR471
C	ASN477
C	PRO491
C	ARG492
C	LEU561

site_id	AF1
Number of Residues	4
Details	binding site for residue EDO C 704

Chain	Residue
C	ARG626
C	ILE627
C	PHE667
C	TYR671

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO C 705

Chain	Residue
C	GLN503
C	TYR552
C	GLN651
C	EDO707

site_id	AF3
Number of Residues	2
Details	binding site for residue EDO C 706

Chain	Residue
C	ARG675
C	GLU676

site_id	AF4
Number of Residues	4
Details	binding site for residue EDO C 707

Chain	Residue
C	GLN503
C	GLN651
C	EDO705
D	ASP446

site_id	AF5
Number of Residues	1
Details	binding site for residue EDO C 708

Chain	Residue
C	GLU540

site_id	AF6
Number of Residues	2
Details	binding site for residue PEG C 709

Chain	Residue
C	ASP665
C	LYS668

site_id	AF7
Number of Residues	4
Details	binding site for residue ZN D 701

Chain	Residue
D	CYS464
D	CYS467
D	CYS490
D	CYS493

site_id	AF8
Number of Residues	4
Details	binding site for residue ZN D 702

Chain	Residue
D	CYS452
D	CYS455
D	HIS472
D	CYS475

site_id	AF9
Number of Residues	3
Details	binding site for residue EDO D 703

Chain	Residue
D	GLN575
D	ARG576
D	ASN578

site_id	AG1
Number of Residues	2
Details	binding site for residue EDO D 704

Chain	Residue
D	LEU561
D	GLU564

Functional Information from PROSITE/UniProt

site_id	PS00598
Number of Residues	21
Details	CHROMO_1 Chromo domain signature. FfVKWqGMsywhc.SWVSelqL

Chain	Residue	Details
A	PHE543-LEU563
A	TYR640-VAL659

site_id	PS01359
Number of Residues	42
Details	ZF_PHD_1 Zinc finger PHD-type signature. CrvCkdggel.......................................LcCdt..Cpss.YHihClnpplpeipnge.................................WlCprC

Chain	Residue	Details
A	CYS452-CYS493

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	188
Details	ZN_FING: PHD-type 2 => ECO:0000255\|PROSITE-ProRule:PRU00146

Chain	Residue	Details
A	MET449-PRO496
B	MET449-PRO496
D	MET449-PRO496
C	MET449-PRO496

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER515
B	SER515
C	SER515
D	SER515

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
A	THR517
B	THR517
C	THR517
D	THR517

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
B	THR529
D	THR529
A	THR529
C	THR529

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER531
B	SER531
C	SER531
D	SER531

site_id	SWS_FT_FI6
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250\|UniProtKB:Q12873

Chain	Residue	Details
A	LYS618
B	LYS618
C	LYS618
D	LYS618

221051

PDB entries from 2024-06-12

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